Results 1 to 10 of about 1,580,087 (314)

H3K36 methyltransferase NSD1 is essential for normal B1 and B2 cell development and germinal center formation

Frontiers in Immunology, 2022
B cells, which consist of two well-defined populations: B1 and B2 cells, which can produce antibodies that are essential for host protection against infections, through virus neutralization, opsonization and antibody-dependent cellular cytotoxicity ...
Sulan Zhai, Min Cao, Han Zhou, Han Zhou, Huamin Zhu, Tongchang Xu, Yuliang Wang, Xiaoming Wang, Xiaoming Wang, Xiaoming Wang, Zhenming Cai   +10 more
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Chronic stress induces pulmonary epithelial cells to produce acetylcholine that remodels lung pre-metastatic niche of breast cancer by enhancing NETosis

Journal of Experimental & Clinical Cancer Research, 2023
Background Chronic stress promotes most hallmarks of cancer through impacting the malignant tissues, their microenvironment, immunity, lymphatic flow, etc.
Jun Pan, Leyi Zhang, Xiaomei Wang, Lili Li, Chenghui Yang, Zhen Wang, Ke Su, Xiaoxiao Hu, Yi Zhang, Guohong Ren, Jiahuan Jiang, Peng Li, Jian Huang   +12 more
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IL-27 Signaling Promotes Th1 Response by Downregulating IL-10 Production in DCs during Chlamydial Respiratory Infection

Microorganisms, 2023
Chlamydia trachomatis usually causes mucosal infections, bringing considerable morbidity and socioeconomic burden worldwide. We previously revealed that IL-27/IL-27R mediates protection against chlamydial invasion by promoting a protective Th1 response ...
Jiajia Zeng, Shuaini Yang, Yuqing Tuo, Xiaoyu Zha, Ruoyuan Sun, Tingsha Lu, Hong Zhang, Lu Tan, Sai Qiao, Hong Bai   +9 more
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A Pathogenic Role for FcγRI in the Immune Response against Chlamydial Respiratory Infection

Microorganisms, 2022
FcγRI is an important cell surface receptor reported to be involved in multiple immune responses, although it has not yet been extensively studied in intracellular bacterial infections. Here, using a mouse model of C.
Jiajia Zeng, Shuaini Yang, Ruoyuan Sun, Yuqing Tuo, Lu Tan, Hong Zhang, Yongci Zhang, Xuchun Che, Tingsha Lu, Xuejun Zhang, Hong Bai   +10 more
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Generation of a Murine Model for c-MYC and BCL2 Co-expression B Cell Lymphomas

Frontiers in Oncology, 2020
Diffuse large B-cell lymphoma (DLBCL) is the most frequent lymphoma in adults, and is characterized as clinically and biologically heterogeneous lymphomas with diverse response to therapy and variation in clinical behavior.
Zhenming Cai, Le Zhang, Le Zhang, Min Cao, Yuliang Wang, Feng Wang, Weiqi Bian, Sulan Zhai, Xiaoming Wang, Xiaoming Wang   +9 more
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Research progress of MDSCs-targeted immunotherapy for pancreatic cancer

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Pancreatic cancer (PC) is a highly malignant digestive system tumor with a poor survival rate and prognosis. Most patients with pancreatic cancer have no obvious clinical manifestations in the early stage of the disease, and are found to be in the middle
QIN Yahan, ZHANG Ke, ZHANG Mengyu, SHEN Jie, PENG Meiyu   +4 more
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Identification of novel immune subtypes and potential hub genes of patients with psoriasis

Journal of Translational Medicine, 2023
Background Psoriasis is a common, chronic and relapsing immune-related inflammatory dermal disease. Patients with psoriasis suffering from the recurrences is mainly caused by immune response disorder.
Yingxi Li, Lin Li, Yao Tian, Jing Luo, Junkai Huang, Litao Zhang, Junling Zhang, Xiaoxia Li, Lizhi Hu   +8 more
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Interactions of Bacterial Toxin CNF1 and Host JAK1/2 Driven by Liquid-Liquid Phase Separation Enhance Macrophage Polarization

mBio, 2022
Urinary tract infections (UTIs) are a global public health concern, which is mainly caused by uropathogenic Escherichia coli (UPEC). Cytotoxic necrotizing factor 1 (CNF1) is a key UPEC toxin and regulates multiple host cellular processes through ...
Xuan Sun, Jianming Yang, Xueqin Deng, Yuting Wei, Changying Wang, Yaxiu Guo, Huan Yang, Liu Yang, Chunhui Miao, Junqiang Lv, Yawen Xiao, Hong Zhang, Zhi Yao, Quan Wang   +13 more
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Pin1 Promotes NLRP3 Inflammasome Activation by Phosphorylation of p38 MAPK Pathway in Septic Shock

Frontiers in Immunology, 2021
Pin1 is the only known peptidyl-prolyl cis-trans isomerase (PPIase) that can specifically recognize and isomerize the phosphorylated Serine/Threonine-Proline (pSer/Thr-Pro) motif, change the conformation of proteins through protein phosphorylation, thus ...
Ruijie Dong, Zhenyi Xue, Guangyue Fan, Na Zhang, Chengzhi Wang, Guangliang Li, Yurong Da   +6 more
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Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization

Nature Communications, 2021
The role of common fragile site associated genes such as FATS in the immune system is unclear. Here the authors show that deletion of Fats in a mouse tumour model leads to reduced tumour growth and change of macrophage phenotype from an M2-like to M1 ...
Lijuan Zhang, Kai Zhang, Jieyou Zhang, Jinrong Zhu, Qing Xi, Huafeng Wang, Zimu Zhang, Yingnan Cheng, Guangze Yang, Hongkun Liu, Xiangdong Guo, Dongmei Zhou, Zhenyi Xue, Yan Li, Qi Zhang, Yurong Da, Li Liu, Zhinan Yin, Zhi Yao, Rongxin Zhang   +19 more
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