Results 1 to 10 of about 2,850,772 (257)

Understanding the tumor immune microenvironment (TIME) for effective therapy

Nature Medicine, 2018
The clinical successes in immunotherapy have been both astounding and at the same time unsatisfactory. Countless patients with varied tumor types have seen pronounced clinical response with immunotherapeutic intervention; however, many more patients have
Edward W Roberts, Kelly Kersten
exaly   +2 more sources

Immunotherapy: Reshape the Tumor Immune Microenvironment

Frontiers in Immunology, 2022
Tumor immune microenvironment (TIME) include tumor cells, immune cells, cytokines, etc. The interactions between these components, which are divided into anti-tumor and pro-tumor, determine the trend of anti-tumor immunity. Although the immune system can
Bin Lv, Yunpeng Wang, Dongjiang Ma, Wei Cheng, Jie Liu, Tao Yong, Hao Chen, Chen Wang   +7 more
exaly   +2 more sources

Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy

Signal Transduction and Targeted Therapy, 2021
Despite great success in cancer immunotherapy, immune checkpoint-targeting drugs are not the most popular weapon in the armory of cancer therapy. Accumulating evidence suggests that the tumor immune microenvironment plays a critical role in anti-cancer ...
Xing Huang, Xueli Bai, Tingbo Liang
exaly   +2 more sources

H3K36 methyltransferase NSD1 is essential for normal B1 and B2 cell development and germinal center formation

Frontiers in Immunology, 2022
B cells, which consist of two well-defined populations: B1 and B2 cells, which can produce antibodies that are essential for host protection against infections, through virus neutralization, opsonization and antibody-dependent cellular cytotoxicity ...
Sulan Zhai, Min Cao, Han Zhou, Han Zhou, Huamin Zhu, Tongchang Xu, Yuliang Wang, Xiaoming Wang, Xiaoming Wang, Xiaoming Wang, Zhenming Cai   +10 more
doaj   +1 more source

Chronic stress induces pulmonary epithelial cells to produce acetylcholine that remodels lung pre-metastatic niche of breast cancer by enhancing NETosis

Journal of Experimental & Clinical Cancer Research, 2023
Background Chronic stress promotes most hallmarks of cancer through impacting the malignant tissues, their microenvironment, immunity, lymphatic flow, etc.
Jun Pan, Leyi Zhang, Xiaomei Wang, Lili Li, Chenghui Yang, Zhen Wang, Ke Su, Xiaoxiao Hu, Yi Zhang, Guohong Ren, Jiahuan Jiang, Peng Li, Jian Huang   +12 more
doaj   +1 more source

IL-27 Signaling Promotes Th1 Response by Downregulating IL-10 Production in DCs during Chlamydial Respiratory Infection

Microorganisms, 2023
Chlamydia trachomatis usually causes mucosal infections, bringing considerable morbidity and socioeconomic burden worldwide. We previously revealed that IL-27/IL-27R mediates protection against chlamydial invasion by promoting a protective Th1 response ...
Jiajia Zeng, Shuaini Yang, Yuqing Tuo, Xiaoyu Zha, Ruoyuan Sun, Tingsha Lu, Hong Zhang, Lu Tan, Sai Qiao, Hong Bai   +9 more
doaj   +1 more source

A Pathogenic Role for FcγRI in the Immune Response against Chlamydial Respiratory Infection

Microorganisms, 2022
FcγRI is an important cell surface receptor reported to be involved in multiple immune responses, although it has not yet been extensively studied in intracellular bacterial infections. Here, using a mouse model of C.
Jiajia Zeng, Shuaini Yang, Ruoyuan Sun, Yuqing Tuo, Lu Tan, Hong Zhang, Yongci Zhang, Xuchun Che, Tingsha Lu, Xuejun Zhang, Hong Bai   +10 more
doaj   +1 more source

Generation of a Murine Model for c-MYC and BCL2 Co-expression B Cell Lymphomas

Frontiers in Oncology, 2020
Diffuse large B-cell lymphoma (DLBCL) is the most frequent lymphoma in adults, and is characterized as clinically and biologically heterogeneous lymphomas with diverse response to therapy and variation in clinical behavior.
Zhenming Cai, Le Zhang, Le Zhang, Min Cao, Yuliang Wang, Feng Wang, Weiqi Bian, Sulan Zhai, Xiaoming Wang, Xiaoming Wang   +9 more
doaj   +1 more source

Research progress of MDSCs-targeted immunotherapy for pancreatic cancer

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Pancreatic cancer (PC) is a highly malignant digestive system tumor with a poor survival rate and prognosis. Most patients with pancreatic cancer have no obvious clinical manifestations in the early stage of the disease, and are found to be in the middle
QIN Yahan, ZHANG Ke, ZHANG Mengyu, SHEN Jie, PENG Meiyu   +4 more
doaj   +1 more source

Single-cell spatial landscapes of the lung tumour immune microenvironment

Nature, 2023
Using imaging mass cytometry, the tumour and immunological spatial landscapes of 416 lung adenocarcinomas are characterized, which, when combined with deep learning, can predict clinical outcomes with high accuracy. Single-cell technologies have revealed
Mark Sorin, Morteza Rezanejad, Elham Karimi, B. Fiset, Lysanne Desharnais, Lucas J M Perus, S. Milette, Miranda W. Yu, S. Maritan, Samuel Doré, É. Pichette, William Enlow, A. Gagné, Yuhong Wei, M. Orain, V. Manem, R. Rayes, P. Siegel, S. Camilleri‐Bröet, P. Fiset, P. Desmeules, J. Spicer, D. Quail, P. Joubert, L. Walsh   +24 more
semanticscholar   +1 more source