Results 21 to 30 of about 2,850,822 (303)

The immune microenvironment of uterine adenosarcomas [PDF]

Clinical Sarcoma Research, 2020
Abstract Background Uterine adenosarcoma (UA) is an extremely rare sarcoma subtype. There has been limited evaluation of the immune microenvironment in these tumors. The objective of this study is to examine and describe the immune infiltrate and PD-1/PD-L1 expression in UA and to correlate these changes in the tumor ...
Ali, Ali Mohammed Refaat, Tsai, Jen-Wei, Leung, Cheuk Hong, Lin, Heather, Ravi, Vinod, Conley, Anthony P., Lazar, Alexander J., Wang, Wei-Lien, Nathenson, Michael J.   +8 more
openaire   +2 more sources

Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

Molecular Cancer, 2021
Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of the tumor microenvironment (TME).
Xiaoqi Mao, Jin Xu, Wei Wang, Chen Liang, J. Hua, Jiang Liu, Bo Zhang, Qingcai Meng, Xianjun Yu, S. Shi   +9 more
semanticscholar   +1 more source

HEV-associated dendritic cells are observed in metastatic tumor-draining lymph nodes of cutaneous melanoma patients with longer distant metastasis-free survival after adjuvant immunotherapy

Frontiers in Immunology, 2023
IntroductionTissue biomarkers that aid in identifying cutaneous melanoma (CM) patients who will benefit from adjuvant immunotherapy are of crucial interest. Metastatic tumor-draining lymph nodes (mTDLN) are the first encounter site between the metastatic
Alicia Inés Bravo, Alicia Inés Bravo, Mariana Aris, Marylou Panouillot, Marylou Panouillot, Marylou Panouillot, Martina Porto, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Jean-Luc Teillaud, Jean-Luc Teillaud, Jean-Luc Teillaud, María Marcela Barrio, José Mordoh, José Mordoh   +15 more
doaj   +1 more source

A comprehensive comparison of circulating tumor cells and breast imaging modalities as screening tools for breast cancer in Chinese women

Frontiers in Oncology, 2022
BackgroundCirculating tumor cells (CTCs) have been recognized as a sensitive biomarker for breast cancer (BC). This study aimed to comprehensively compare CTC with imaging modalities, including ultrasonography, mammography, and contrast-enhanced magnetic
Xuan Shao, Xuan Shao, Xiaoyan Jin, Xiaoyan Jin, Xiaoyan Jin, Zhigang Chen, Zhigang Chen, Zhigang Zhang, Zhigang Zhang, Wuzhen Chen, Wuzhen Chen, Jingxin Jiang, Jingxin Jiang, Zhen Wang, Zhen Wang, Ying Cui, Wan-Hung Fan, Ke Wang, Ke Wang, Xiuyan Yu, Xiuyan Yu, Jian Huang, Jian Huang   +22 more
doaj   +1 more source

The role of Microenvironment in tumorigenesis. Focus on dendritic cells in human papillomavirus E6, E7-transformed keratinocytes [PDF]

, 2015
The inception of tumor microenvironment (TME), a complex and dynamic system constituted by different types of cells engaged by tumor and extracellular matrix surrounding cancer cells, is a way for them to elude the immune surveillance.
Accardi, Rosita, CHIANTORE, Maria Vincenza, Fiorucci, Gianna, IULIANO, MARCO, MANGINO, GIORGIO, ROMEO, Giovanna, Tommasino, Massimo   +6 more
core   +1 more source

A human lung tumor microenvironment interactome identifies clinically relevant cell-type cross-talk. [PDF]

, 2020
BackgroundTumors comprise a complex microenvironment of interacting malignant and stromal cell types. Much of our understanding of the tumor microenvironment comes from in vitro studies isolating the interactions between malignant cells and a single ...
Azizi, Armon, Bejnood, Alborz, Bouchard, Gina, Diehn, Maximilian, Feng, Weiguo, Forgó, Erna, Gentles, Andrew J, Hoang, Chuong D, Hui, Angela Bik-Yu, Jeong, Youngtae, Knowles, David A, Kuong, Amanda, Nair, Ramesh V, Nair, Viswam S, Plevritis, Sylvia K, van de Rijn, Matt, Varma, Sushama, West, Rob, Xu, Yue, Yu, Alice   +19 more
core   +4 more sources

Managing the immune microenvironment of osteosarcoma: the outlook for osteosarcoma treatment

Bone Research, 2023
Osteosarcoma, with poor survival after metastasis, is considered the most common primary bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival rate has only shown limited improvement, suggesting that existing ...
Hailong Tian, Jiangjun Cao, Bowen Li, E. Nice, Haijiao Mao, Yi Zhang, Canhua Huang   +6 more
semanticscholar   +1 more source

Immune Microenvironment in Hematologic Malignancies.

Iranian journal of medical sciences, 2023
The role of the tumor microenvironment (TME), especially immune cell compartments, in tumor progression is inevitable and the heterogeneity and complexity of the TME-associated immune cells make it challenging to provide appropriate treatments for hematologic malignancies.
Arandi, Nargess, Dehghani, Mehdi
openaire   +3 more sources

Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization

Nature Communications, 2021
The role of common fragile site associated genes such as FATS in the immune system is unclear. Here the authors show that deletion of Fats in a mouse tumour model leads to reduced tumour growth and change of macrophage phenotype from an M2-like to M1 ...
Lijuan Zhang, Kai Zhang, Jieyou Zhang, Jinrong Zhu, Qing Xi, Huafeng Wang, Zimu Zhang, Yingnan Cheng, Guangze Yang, Hongkun Liu, Xiangdong Guo, Dongmei Zhou, Zhenyi Xue, Yan Li, Qi Zhang, Yurong Da, Li Liu, Zhinan Yin, Zhi Yao, Rongxin Zhang   +19 more
doaj   +1 more source

The Liver Cancer Immune Microenvironment: Therapeutic Implications for Hepatocellular Carcinoma

Hepatology, 2022
The liver is the sixth most common site of primary cancer in humans and the fourth leading cause of cancer‐related death in the world. Hepatocellular carcinoma (HCC) accounts for 90% of liver cancers. HCC is a prevalent disease with a progression that is
Romain Donné, A. Lujambio
semanticscholar   +1 more source