Cytokine-Induced Senescence in the Tumor Microenvironment and Its Effects on Anti-Tumor Immune Responses [PDF]
, 2022 In contrast to surgical excision, chemotherapy or radiation therapy, immune checkpoint blockade therapies primarily influence cells in the tumor microenvironment, especially the tumor-associated lymphocytes and antigen-presenting cells.
Priscilla S. Briquez +3 more
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Enhanced Thermogenesis in Triple-Negative Breast Cancer Is Associated with Pro-Tumor Immune Microenvironment [PDF]
, 2021 Mild cold stress induced by housing mice with a 4T1 triple-negative breast cancer (TNBC) cell implantation model at 22 °C increases tumor growth rate with a pro-tumorigenic immune microenvironment (lower CD8 +T cells, higher myeloid-derived suppressor ...
Vijayashree Murthy +4 more
core +1 more source
A Pathogenic Role for FcγRI in the Immune Response against Chlamydial Respiratory Infection
Microorganisms, 2022 FcγRI is an important cell surface receptor reported to be involved in multiple immune responses, although it has not yet been extensively studied in intracellular bacterial infections. Here, using a mouse model of C.
Jiajia Zeng +10 more
doaj +1 more source
Interdependencies of the Neuronal, Immune and Tumor Microenvironment in Gliomas [PDF]
, 2023 Gliomas are the most common primary brain malignancy and are universally fatal. Despite significant breakthrough in understanding tumor biology, treatment breakthroughs have been limited.
Mustafa Khasraw +4 more
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Generation of a Murine Model for c-MYC and BCL2 Co-expression B Cell Lymphomas
Frontiers in Oncology, 2020 Diffuse large B-cell lymphoma (DLBCL) is the most frequent lymphoma in adults, and is characterized as clinically and biologically heterogeneous lymphomas with diverse response to therapy and variation in clinical behavior.
Zhenming Cai +9 more
doaj +1 more source
The Cellular Tumor Immune Microenvironment of Childhood Solid Cancers: Informing More Effective Immunotherapies [PDF]
, 2022 SIMPLE SUMMARY: Cellular immunotherapy has emerged as a novel treatment modality of cancer but is largely inefficient in solid cancers of childhood and adolescence.
Altvater, Bianca +7 more
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Research progress of MDSCs-targeted immunotherapy for pancreatic cancer
Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023 Pancreatic cancer (PC) is a highly malignant digestive system tumor with a poor survival rate and prognosis. Most patients with pancreatic cancer have no obvious clinical manifestations in the early stage of the disease, and are found to be in the middle
QIN Yahan +4 more
doaj +1 more source
Identification of novel immune subtypes and potential hub genes of patients with psoriasis
Journal of Translational Medicine, 2023 Background Psoriasis is a common, chronic and relapsing immune-related inflammatory dermal disease. Patients with psoriasis suffering from the recurrences is mainly caused by immune response disorder.
Yingxi Li +8 more
doaj +1 more source
mBio, 2022 Urinary tract infections (UTIs) are a global public health concern, which is mainly caused by uropathogenic Escherichia coli (UPEC). Cytotoxic necrotizing factor 1 (CNF1) is a key UPEC toxin and regulates multiple host cellular processes through ...
Xuan Sun +13 more
doaj +1 more source
Prognostic Value and Immune Infiltration of HPV-Related Genes in the Immune Microenvironment of Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma [PDF]
, 2023 Mounting evidence has highlighted the immune environment as a critical feature in the development of cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC).
Qiyu Gan +6 more
core +1 more source