Results 21 to 30 of about 1,580,087 (314)

The Immune Microenvironment and Cancer Metastasis [PDF]

Cold Spring Harbor Perspectives in Medicine, 2019
The dynamic interplay between neoplastic cells and the immune microenvironment regulates every step of the metastatic process. Immune cells contribute to invasion by secreting a cornucopia of inflammatory factors that promote epithelial-to-mesenchymal transition and remodeling of the stroma.
Asmaa, El-Kenawi, Kay, Hänggi, Brian, Ruffell   +2 more
openaire   +2 more sources

HEV-associated dendritic cells are observed in metastatic tumor-draining lymph nodes of cutaneous melanoma patients with longer distant metastasis-free survival after adjuvant immunotherapy

Frontiers in Immunology, 2023
IntroductionTissue biomarkers that aid in identifying cutaneous melanoma (CM) patients who will benefit from adjuvant immunotherapy are of crucial interest. Metastatic tumor-draining lymph nodes (mTDLN) are the first encounter site between the metastatic
Alicia Inés Bravo, Alicia Inés Bravo, Mariana Aris, Marylou Panouillot, Marylou Panouillot, Marylou Panouillot, Martina Porto, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Jean-Luc Teillaud, Jean-Luc Teillaud, Jean-Luc Teillaud, María Marcela Barrio, José Mordoh, José Mordoh   +15 more
doaj   +1 more source

A comprehensive comparison of circulating tumor cells and breast imaging modalities as screening tools for breast cancer in Chinese women

Frontiers in Oncology, 2022
BackgroundCirculating tumor cells (CTCs) have been recognized as a sensitive biomarker for breast cancer (BC). This study aimed to comprehensively compare CTC with imaging modalities, including ultrasonography, mammography, and contrast-enhanced magnetic
Xuan Shao, Xuan Shao, Xiaoyan Jin, Xiaoyan Jin, Xiaoyan Jin, Zhigang Chen, Zhigang Chen, Zhigang Zhang, Zhigang Zhang, Wuzhen Chen, Wuzhen Chen, Jingxin Jiang, Jingxin Jiang, Zhen Wang, Zhen Wang, Ying Cui, Wan-Hung Fan, Ke Wang, Ke Wang, Xiuyan Yu, Xiuyan Yu, Jian Huang, Jian Huang   +22 more
doaj   +1 more source

The Immune Microenvironment of Malignant Pleural Mesothelioma: A Literature Review

, 2021
Malignant pleural mesothelioma (MPM) is a rare and aggressive tumour with a poor prognosis, associated with asbestos exposure. Nowadays, treatment is based on chemotherapy with a median overall survival of less than two years.
Anne-Laure Désage, Marios E. Froudarakis, Georgia Karpathiou, Michel Peoc’h   +3 more
core   +1 more source

The immune microenvironment of uterine adenosarcomas [PDF]

Clinical Sarcoma Research, 2020
Abstract Background Uterine adenosarcoma (UA) is an extremely rare sarcoma subtype. There has been limited evaluation of the immune microenvironment in these tumors. The objective of this study is to examine and describe the immune infiltrate and PD-1/PD-L1 expression in UA and to correlate these changes in the tumor ...
Ali, Ali Mohammed Refaat, Tsai, Jen-Wei, Leung, Cheuk Hong, Lin, Heather, Ravi, Vinod, Conley, Anthony P., Lazar, Alexander J., Wang, Wei-Lien, Nathenson, Michael J.   +8 more
openaire   +2 more sources

Immune Cells in the Tumor Microenvironment of Soft Tissue Sarcomas

, 2023
Soft tissue sarcomas (STSs) are a rare heterogeneous group of malignant neoplasms characterized by their aggressive course and poor response to treatment. This determines the relevance of research aimed at studying the pathogenesis of STSs. By now, it is
Timur Fatkhudinov, Enar Jumaniyazova, Anastasiya Lokhonina, Dzhuliia Dzhalilova, Anna Kosyreva   +4 more
core   +1 more source

Role of Intra- and Extracellular Lipid Signals in Cancer Stemness and Potential Therapeutic Strategy

Frontiers in Pharmacology, 2021
Accumulating evidence showed that cancer stem cells (CSCs) play significant roles in cancer initiation, resistance to therapy, recurrence and metastasis. Cancer stem cells possess the ability of self-renewal and can initiate tumor growth and avoid lethal
Jianming Hu, Jianming Hu, Leyi Zhang, Leyi Zhang, Wuzhen Chen, Wuzhen Chen, Lesang Shen, Lesang Shen, Jingxin Jiang, Jingxin Jiang, Shanshan Sun, Shanshan Sun, Zhigang Chen, Zhigang Chen   +13 more
doaj   +1 more source

Cytokine-Induced Senescence in the Tumor Microenvironment and Its Effects on Anti-Tumor Immune Responses

, 2022
In contrast to surgical excision, chemotherapy or radiation therapy, immune checkpoint blockade therapies primarily influence cells in the tumor microenvironment, especially the tumor-associated lymphocytes and antigen-presenting cells.
Priscilla S. Briquez, Heidi Braumüller, Maximilian Rentschler, Thomas Wieder   +3 more
core   +1 more source

The immune microenvironment of the hydatidiform mole

Human Pathology, 2022
Gestational trophoblastic diseases (GTDs) are a heterogeneous group of lesions, the most frequent being the hydatidiform mole (HM). HMs are usually cured after surgical treatment or after chemotherapy in the case of a persistent trophoblastic activity. Immunotherapy could be an interesting alternative as a first-line or second-line treatment.
Dridi, Maroa, Papoudou-Bai, Alexandra, Kanavaros, Panagiotis, Perard, Marine, Clemenson, Alix, Chauleur, Céline, Peoc’h, Michel, Karpathiou, Georgia   +7 more
openaire   +4 more sources

FGF9 Alleviates the Fatty Liver Phenotype by Regulating Hepatic Lipid Metabolism

Frontiers in Pharmacology, 2022
Although the fatty liver has been linked to numerous impairments of energy homeostasis, the molecular mechanism responsible for fatty liver development remains largely unknown.
Fanrong Zhao, Lei Zhang, Menglin Zhang, Jincan Huang, Jun Zhang, Yongsheng Chang   +5 more
doaj   +1 more source