Results 31 to 40 of about 1,580,087 (314)

Interdependencies of the Neuronal, Immune and Tumor Microenvironment in Gliomas

, 2023
Gliomas are the most common primary brain malignancy and are universally fatal. Despite significant breakthrough in understanding tumor biology, treatment breakthroughs have been limited.
Mustafa Khasraw, Kelly M. Hotchkiss, Alexander Yuile, Aditya A. Mohan, Joe Q. Wei   +4 more
core   +1 more source

C9orf16 represents the aberrant genetic programs and drives the progression of PDAC

BMC Cancer, 2022
Background Pancreatic ductal adenocarcinoma (PDAC), constituting 90% of pancreatic cancers, is the fourth leading cause of cancer-related deaths in the world.
Xiaojun Chen, Hong Zhang, Bo Xiao
doaj   +1 more source

Enhanced Thermogenesis in Triple-Negative Breast Cancer Is Associated with Pro-Tumor Immune Microenvironment

, 2021
Mild cold stress induced by housing mice with a 4T1 triple-negative breast cancer (TNBC) cell implantation model at 22 °C increases tumor growth rate with a pro-tumorigenic immune microenvironment (lower CD8 +T cells, higher myeloid-derived suppressor ...
Vijayashree Murthy, Masanori Oshi, Kazuaki Takabe, Shipra Gandhi, Elizabeth A. Repasky   +4 more
core   +1 more source

Deregulation of PRDM5 promotes cell proliferation by regulating JAK/STAT signaling pathway through SOCS1 in human lung adenocarcinoma

Cancer Medicine, 2023
Background PRDM5 is considered a tumor suppressor in several types of solid tumors and is involved in multiple cellular processes. However, target genes regulated by PRDM5 in lung cancer and its potential mechanism are poorly defined.
Yuanyuan Ren, Ye Wang, Lijiao Fang, Mengchu Ma, Lin Ge, Chao Su, Lingbiao Xin, Jinyan He, Jie Yang, Xin Liu   +9 more
doaj   +1 more source

The Cellular Tumor Immune Microenvironment of Childhood Solid Cancers: Informing More Effective Immunotherapies

, 2022
SIMPLE SUMMARY: Cellular immunotherapy has emerged as a novel treatment modality of cancer but is largely inefficient in solid cancers of childhood and adolescence.
Altvater, Bianca, Sareetha Kailayangiri, Kailayangiri, Sareetha, Malcolm Holterhus, Rossig, Claudia, Bianca Altvater, Holterhus, Malcolm, Claudia Rossig   +7 more
core   +1 more source

Adiponectin modulates oxidative stress-induced mitophagy and protects C2C12 myoblasts against apoptosis

Scientific Reports, 2017
Adiponectin (APN), also known as apM1, Acrp30, GBP28 and adipoQ, is a circulating hormone that is predominantly produced by adipose tissue. Many pharmacological studies have demonstrated that this protein possesses potent anti-diabetic, anti-atherogenic ...
Yinghui Ren, Yan Li, Jun Yan, Mingkun Ma, Dongmei Zhou, Zhenyi Xue, Zimu Zhang, Hongkun Liu, Huipeng Yang, Long Jia, Lijuan Zhang, Qi Zhang, Shuqin Mu, Rongxin Zhang, Yurong Da   +14 more
doaj   +1 more source

Structure of Rad5 provides insights into its role in tolerance to replication stress

Molecular & Cellular Oncology, 2021
The Rad5 family of proteins are critical genome maintenance factors, with helicase-like transcription factor (HLTF) and SNF2 histone linker PHD RING helicase (SHRPH) in humans implicated in several types of cancer.
Miaomiao Shen, Nalini Dhingra, Quan Wang, Xiaoxin Gong, Xin Xu, Hengyao Niu, Xiaolan Zhao, Song Xiang   +7 more
doaj   +1 more source

Simultaneous suppression of PKM2 and PHGDH elicits synergistic anti-cancer effect in NSCLC

Frontiers in Pharmacology, 2023
Metabolic reprogramming is a hallmark of human cancer. Cancer cells exhibit enhanced glycolysis, which allows glycolytic intermediates to be diverted into several other biosynthetic pathways, such as serine synthesis.
Kaixuan Wang, Hao Lu, Xinmiao Wang, Qingxia Liu, Jinxia Hu, Yao Liu, Yao Liu, Meihua Jin, Dexin Kong   +8 more
doaj   +1 more source

Clinical Strategies Targeting the Tumor Microenvironment of Pancreatic Ductal Adenocarcinoma

, 2022
Pancreatic cancer has a complex tumor microenvironment which engages in extensive crosstalk between cancer cells, cancer-associated fibroblasts, and immune cells. Many of these interactions contribute to tumor resistance to anti-cancer therapies.
Christine Alewine, Samuel L. Ricci, Palestino Dominguez, Mayrel, Nebojsa Skorupan, Mayrel Palestino Dominguez, Alewine, Christine, Ricci, Samuel L., Skorupan, Nebojsa   +7 more
core   +1 more source

Static Magnetic Field Accelerates Diabetic Wound Healing by Facilitating Resolution of Inflammation

Journal of Diabetes Research, 2019
Impaired wound healing is commonly encountered in patients with diabetes mellitus, which may lead to severe outcomes such as amputation, if untreated timely. Macrophage plays a critical role in the healing process including the resolution phase. Although
Wenlong Shang, Guilin Chen, Yinxiu Li, Yujuan Zhuo, Yuhong Wang, Zhicai Fang, Ying Yu, Huiwen Ren   +7 more
doaj   +1 more source