Results 31 to 40 of about 465,229 (318)

Immune Microenvironment in Glioblastoma Subtypes [PDF]

Frontiers in Immunology, 2018
Glioblastomas (GBMs) are the most common and aggressive primary brain tumors. Due to their malignant growth and invasion into the brain parenchyma coupled with resistance to therapy, GBMs are among the deadliest of all cancers. GBMs are highly heterogeneous at both the molecular and histological levels.
Zhihong Chen, Dolores Hambardzumyan
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The immune microenvironment of uterine adenosarcomas [PDF]

Clinical Sarcoma Research, 2020
Abstract Background Uterine adenosarcoma (UA) is an extremely rare sarcoma subtype. There has been limited evaluation of the immune microenvironment in these tumors. The objective of this study is to examine and describe the immune infiltrate and PD-1/PD-L1 expression in UA and to correlate these changes in the tumor ...
Ali, Ali Mohammed Refaat, Tsai, Jen-Wei, Leung, Cheuk Hong, Lin, Heather, Ravi, Vinod, Conley, Anthony P., Lazar, Alexander J., Wang, Wei-Lien, Nathenson, Michael J.   +8 more
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Clinical Strategies Targeting the Tumor Microenvironment of Pancreatic Ductal Adenocarcinoma [PDF]

, 2022
Pancreatic cancer has a complex tumor microenvironment which engages in extensive crosstalk between cancer cells, cancer-associated fibroblasts, and immune cells. Many of these interactions contribute to tumor resistance to anti-cancer therapies.
Christine Alewine, Samuel L. Ricci, Palestino Dominguez, Mayrel, Nebojsa Skorupan, Mayrel Palestino Dominguez, Alewine, Christine, Ricci, Samuel L., Skorupan, Nebojsa   +7 more
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Pin1 Promotes NLRP3 Inflammasome Activation by Phosphorylation of p38 MAPK Pathway in Septic Shock

Frontiers in Immunology, 2021
Pin1 is the only known peptidyl-prolyl cis-trans isomerase (PPIase) that can specifically recognize and isomerize the phosphorylated Serine/Threonine-Proline (pSer/Thr-Pro) motif, change the conformation of proteins through protein phosphorylation, thus ...
Ruijie Dong, Zhenyi Xue, Guangyue Fan, Na Zhang, Chengzhi Wang, Guangliang Li, Yurong Da   +6 more
doaj   +1 more source

The Tumor Immune Microenvironment in Pancreatic Ductal Adenocarcinoma: Neither Hot nor Cold [PDF]

, 2022
Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic tumor and is associated with poor prognosis and treatment response. The tumor microenvironment (TME) is recognized as an important factor in metastatic progression across cancers ...
Sojwal, Raoul S., Samuel J. S. Rubin, John Gubatan, Rubin, Samuel J. S., Gubatan, John, Raoul S. Sojwal, Rogalla, Stephan, Stephan Rogalla   +7 more
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HEV-associated dendritic cells are observed in metastatic tumor-draining lymph nodes of cutaneous melanoma patients with longer distant metastasis-free survival after adjuvant immunotherapy

Frontiers in Immunology, 2023
IntroductionTissue biomarkers that aid in identifying cutaneous melanoma (CM) patients who will benefit from adjuvant immunotherapy are of crucial interest. Metastatic tumor-draining lymph nodes (mTDLN) are the first encounter site between the metastatic
Alicia Inés Bravo, Alicia Inés Bravo, Mariana Aris, Marylou Panouillot, Marylou Panouillot, Marylou Panouillot, Martina Porto, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Jean-Luc Teillaud, Jean-Luc Teillaud, Jean-Luc Teillaud, María Marcela Barrio, José Mordoh, José Mordoh   +15 more
doaj   +1 more source

Engineering the tumor microenvironment of colorectal cancer [PDF]

, 2014
The tumor microenvironment contributes significantly to the clinical prognosis, especially in CRC. Infiltration by cells from the adaptive immune system (e.g. CD8) has been linked to a better survival independently of TNM-stage.
Hirt, Christian Kurt
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The Immune Microenvironment of Chordomas: An Immunohistochemical Analysis [PDF]

, 2021
International audienceChordomas are rare sarcomas that are usually treated by surgery and/or radiotherapy since these are chemo-resistant tumors, but immunotherapy could be a possible option for chordoma patients.
Timothée Jacquesson, Meyronet, David, Péoc’h, Michel, Vassal, François, Dridi, Maroa, Lila Krebs-Drouot, David Meyronet, Georgia Karpathiou, Grange, Sylvain, François Vassal, Jean Boutonnat, Boutonnat, Jean, Emmanuel Jouanneau, Jouanneau, Emmanuel, Krebs-Drouot, Lila, Maroa Dridi, Karpathiou, Georgia, Jean Marc Dumollard, Michel Péoc’h, Cédric Barrey, Sylvain Grange, Jacquesson, Timothée, Barrey, Cédric, Dumollard, Jean Marc   +23 more
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A comprehensive comparison of circulating tumor cells and breast imaging modalities as screening tools for breast cancer in Chinese women

Frontiers in Oncology, 2022
BackgroundCirculating tumor cells (CTCs) have been recognized as a sensitive biomarker for breast cancer (BC). This study aimed to comprehensively compare CTC with imaging modalities, including ultrasonography, mammography, and contrast-enhanced magnetic
Xuan Shao, Xuan Shao, Xiaoyan Jin, Xiaoyan Jin, Xiaoyan Jin, Zhigang Chen, Zhigang Chen, Zhigang Zhang, Zhigang Zhang, Wuzhen Chen, Wuzhen Chen, Jingxin Jiang, Jingxin Jiang, Zhen Wang, Zhen Wang, Ying Cui, Wan-Hung Fan, Ke Wang, Ke Wang, Xiuyan Yu, Xiuyan Yu, Jian Huang, Jian Huang   +22 more
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Immune Microenvironment in Hematologic Malignancies.

Iranian journal of medical sciences, 2023
The role of the tumor microenvironment (TME), especially immune cell compartments, in tumor progression is inevitable and the heterogeneity and complexity of the TME-associated immune cells make it challenging to provide appropriate treatments for hematologic malignancies.
Arandi, Nargess, Dehghani, Mehdi
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