Crosstalk between Thyroid Carcinoma and Tumor-Correlated Immune Cells in the Tumor Microenvironment [PDF]
, 2023 Thyroid cancer (TC) is the most common malignancy in the endocrine system. Although most TC can achieve a desirable prognosis, some refractory thyroid carcinomas, including radioiodine-refractory differentiated thyroid cancer, as well as anaplastic ...
Mingyuan Song +3 more
core +1 more source
Nature Communications, 2021 The role of common fragile site associated genes such as FATS in the immune system is unclear. Here the authors show that deletion of Fats in a mouse tumour model leads to reduced tumour growth and change of macrophage phenotype from an M2-like to M1 ...
Lijuan Zhang +19 more
doaj +1 more source
The Influence of the Ketogenic Diet on the Immune Tolerant Microenvironment in Glioblastoma [PDF]
, 2022 Glioblastoma (GBM) represents an aggressive and immune-resistant cancer. Preclinical investigations have identified anti-tumor activity of a ketogenic diet (KD) potentially being used to target GBM’s glycolytic phenotype.
Chinnaiyan, Prakash +9 more
core +1 more source
Reshaping the Pancreatic Cancer Microenvironment at Different Stages with Chemotherapy [PDF]
, 2023 The dynamic tumor microenvironment, especially the immune microenvironment, during the natural progression and/or chemotherapy treatment is a critical frontier in understanding the effects of chemotherapy on pancreatic cancer.
Ying Ying +4 more
core +1 more source
Role of Intra- and Extracellular Lipid Signals in Cancer Stemness and Potential Therapeutic Strategy
Frontiers in Pharmacology, 2021 Accumulating evidence showed that cancer stem cells (CSCs) play significant roles in cancer initiation, resistance to therapy, recurrence and metastasis. Cancer stem cells possess the ability of self-renewal and can initiate tumor growth and avoid lethal
Jianming Hu +13 more
doaj +1 more source
The immune microenvironment of the hydatidiform mole
Human Pathology, 2022 Gestational trophoblastic diseases (GTDs) are a heterogeneous group of lesions, the most frequent being the hydatidiform mole (HM). HMs are usually cured after surgical treatment or after chemotherapy in the case of a persistent trophoblastic activity. Immunotherapy could be an interesting alternative as a first-line or second-line treatment.
Maroa Dridi +7 more
openaire +3 more sources
The Immune Microenvironment in Pancreatic Cancer [PDF]
International Journal of Molecular Sciences, 2020 The biology of solid tumors is strongly determined by the interactions of cancer cells with their surrounding microenvironment. In this regard, pancreatic cancer (pancreatic ductal adenocarcinoma, PDAC) represents a paradigmatic example for the multitude of possible tumor–stroma interactions.
Magdalena Huber +9 more
openaire +2 more sources
Modeling the Tumor Microenvironment and Cancer Immunotherapy in Next-Generation Humanized Mice [PDF]
, 2023 Cancer immunotherapy has brought significant clinical benefits to numerous patients with malignant disease. However, only a fraction of patients experiences complete and durable responses to currently available immunotherapies.
Dietmar Herndler-Brandstetter +2 more
core +1 more source
PD-L1/PD-1 Axis in Multiple Myeloma Microenvironment and a Possible Link with CD38-Mediated Immune-Suppression [PDF]
, 2021 The emerging role of the PD-1/PD-L1 axis in MM immune-microenvironment has been highlighted by several studies. However, discordant data have been reported on PD-1/PD-L1 distribution within the bone marrow (BM) microenvironment of patients with ...
Federica Costa +4 more
core +1 more source
FGF9 Alleviates the Fatty Liver Phenotype by Regulating Hepatic Lipid Metabolism
Frontiers in Pharmacology, 2022 Although the fatty liver has been linked to numerous impairments of energy homeostasis, the molecular mechanism responsible for fatty liver development remains largely unknown.
Fanrong Zhao +5 more
doaj +1 more source