Results 41 to 50 of about 1,580,087 (314)

Prognostic Value and Immune Infiltration of HPV-Related Genes in the Immune Microenvironment of Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma

, 2023
Mounting evidence has highlighted the immune environment as a critical feature in the development of cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC).
Qiyu Gan, Rui Chen, Rui Shi, Jingxin Cheng, Linlin Chang, Luning Mao, Guozeng Wang   +6 more
core   +1 more source

Engaging the Immune Response to Normalize the Tumor Microenvironment [PDF]

, 2013
Solid tumors exist as heterogeneous populations comprised not only of malignant cells, but various other cell types, including cells that make up the vasculature, that can strongly influence tumorgenicity.
Sabins, Nina, Storkus, Walter
core  

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Deficiency of NF‐Erythroid 2‐Related Factor 2 Exacerbates the Scar Through ERK Signaling Pathway

Immunity, Inflammation and Disease
Background Scar, primarily composed of poorly structured and disordered collagen, is mainly characterized by excessive fibroblast activation and abnormal collagen deposition.
Xueyuan Hao, Mengke Sun, Ruotong Wang, Hong Chen, Junkai Huang, Jing Luo, Haoyue Yu, Yingxi Li, Weibin Xing, Xiaoxia Li, Lizhi Hu   +10 more
doaj   +1 more source

Research progress in the role of β-arrestin 1 in the regulation of inflammatory response

Shanghai Jiaotong Daxue xuebao. Yixue ban
The inflammatory response is a systemic process produced by the body in response to stimulation such as infection or injury. The inflammatory response is closely related to the pathogenesis of various diseases, and plays an important role in the ...
YI Wenjing, FAN Yixuan, QIU Jiatai, FU Xiaoyan, LIU Meifang   +4 more
doaj   +1 more source

The Tumor Immune Microenvironment in Pancreatic Ductal Adenocarcinoma: Neither Hot nor Cold

, 2022
Pancreatic ductal adenocarcinoma (PDAC) is the most common pancreatic tumor and is associated with poor prognosis and treatment response. The tumor microenvironment (TME) is recognized as an important factor in metastatic progression across cancers ...
Sojwal, Raoul S., Samuel J. S. Rubin, John Gubatan, Rubin, Samuel J. S., Gubatan, John, Raoul S. Sojwal, Rogalla, Stephan, Stephan Rogalla   +7 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Immune podocytes in the immune microenvironment of lupus nephritis (Review)

Molecular Medicine Reports, 2023
Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder caused by the loss of tolerance to endogenous nuclear antigens such as double‑stranded DNA, leading to the proliferation of T cells and subsequent activation of B cells, which results in serious organ damage and life‑threatening complications such as lupus nephritis.
Liu, Ruiling, Wen, Xiaoting, Peng, Xinyue, Zhao, Miaomiao, Mi, Liangyu, Lei, Jiamin, Xu, Ke   +6 more
openaire   +2 more sources

CD38 Predicts Favorable Prognosis by Enhancing Immune Infiltration and Antitumor Immunity in the Epithelial Ovarian Cancer Microenvironment

Frontiers in Genetics, 2020
The identification of predictive biomarkers and novel targets to optimize immunotherapy strategies for epithelial ovarian cancer (EOC) is urgently needed. CD38 is a multifunctional glycoprotein that acts as an ectoenzyme and immune receptor. However, the
Ying Zhu, Ying Zhu, Zhigang Zhang, Zhigang Zhang, Zhou Jiang, Yang Liu, Yang Liu, Jianwei Zhou   +7 more
doaj   +1 more source

Crosstalk between Thyroid Carcinoma and Tumor-Correlated Immune Cells in the Tumor Microenvironment

, 2023
Thyroid cancer (TC) is the most common malignancy in the endocrine system. Although most TC can achieve a desirable prognosis, some refractory thyroid carcinomas, including radioiodine-refractory differentiated thyroid cancer, as well as anaplastic ...
Mingyuan Song, Hao Zhang, Wei Sun, Qi Liu   +3 more
core   +1 more source