Results 51 to 60 of about 1,580,087 (314)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Cancer associated fibroblast–derived CCL5 promotes hepatocellular carcinoma metastasis through activating HIF1α/ZEB1 axis

Cell Death and Disease, 2022
Cancer-associated fibroblasts (CAFs) are one of the most enriched components of Hepatocellular carcinoma (HCC) microenvironment, which are tightly related to the metastasis and invasion of HCC.
Haixu Xu, Jie Zhao, Jinping Li, Zhifeng Zhu, Zhaohai Cui, Ran Liu, Rong Lu, Zhi Yao, Qiong Xu   +8 more
doaj   +1 more source

The Immune Microenvironment of Chordomas: An Immunohistochemical Analysis

, 2021
International audienceChordomas are rare sarcomas that are usually treated by surgery and/or radiotherapy since these are chemo-resistant tumors, but immunotherapy could be a possible option for chordoma patients.
Timothée Jacquesson, Meyronet, David, Péoc’h, Michel, Vassal, François, Dridi, Maroa, Lila Krebs-Drouot, David Meyronet, Georgia Karpathiou, Grange, Sylvain, François Vassal, Jean Boutonnat, Boutonnat, Jean, Emmanuel Jouanneau, Jouanneau, Emmanuel, Krebs-Drouot, Lila, Maroa Dridi, Karpathiou, Georgia, Jean Marc Dumollard, Michel Péoc’h, Cédric Barrey, Sylvain Grange, Jacquesson, Timothée, Barrey, Cédric, Dumollard, Jean Marc   +23 more
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Tumor immune microenvironment (TIME) to enhance antitumor immunity

European Journal of Medical Research, 2023
AbstractThe tumor microenvironment is a result of dynamic interaction between different cellular and non-cellular components. In its essence it is not a solo performer, but an ensemble of performers that includes cancer cells, fibroblasts, myo-fibroblasts, endothelial cells and immune cells.
Sajin Rajbhandary, Hari Dhakal, Sudip Shrestha   +2 more
openaire   +3 more sources

Zinc-copper bimetallic nanoplatforms trigger photothermal-amplified cuproptosis and cGAS-STING activation for enhancing triple-negative breast cancer immunotherapy

Journal of Nanobiotechnology
Triple-negative breast cancer (TNBC) is characterized by high rates of metastasis and recurrence, along with a low sensitivity to immunotherapy, resulting in a paucity of effective therapeutic strategies.
Bangyi Zhou, Mengyao Chen, Zhixing Hao, Lili Li, Yixin Zhang, Baoru Fang, Miner Shao, Guohong Ren, Ke Wang, Huiying Liu, Jingxuan Zhu, Xinyi Zhang, Shuyan Yuan, I Sitou, Jing Zhao, Jian Huang, Zhangsen Yu, Fuming Qiu   +17 more
doaj   +1 more source

Modeling the Tumor Microenvironment and Cancer Immunotherapy in Next-Generation Humanized Mice

, 2023
Cancer immunotherapy has brought significant clinical benefits to numerous patients with malignant disease. However, only a fraction of patients experiences complete and durable responses to currently available immunotherapies.
Dietmar Herndler-Brandstetter, Anna Chen, Ines Neuwirth   +2 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Tumor necrosis factor receptor 2 promotes endothelial cell-mediated suppression of CD8+ T cells through tuning glycolysis in chemoresistance of breast cancer

Journal of Translational Medicine
Background T cells play a pivotal role in chemotherapy-triggered anti-tumor effects. Emerging evidence underscores the link between impaired anti-tumor immune responses and resistance to paclitaxel therapy in triple-negative breast cancer (TNBC).
Yu Hu, Xiaohan Lou, Kaili Zhang, Longze Pan, Yueyue Bai, Linlin Wang, Ming Wang, Yan Yan, Jiajia Wan, Xiaohan Yao, Xixi Duan, Chen Ni, Zhihai Qin   +12 more
doaj   +1 more source

CD24 blunts the sensitivity of retinoblastoma to vincristine by modulating autophagy

Molecular Oncology, 2020
Retinoblastoma (RB) is the most common childhood malignant intraocular tumor. The clinical efficacy of vincristine (VCR) in the treatment of RB is severely limited by drug resistance. Here, we found that CD24, a GPI‐anchored protein, was overexpressed in
Jie Sun, Dongju Feng, Huiyu Xi, Jiajing Luo, Zewei Zhou, Qinghuai Liu, Yun Chen, Qing Shao   +7 more
doaj   +1 more source