Results 71 to 80 of about 2,850,822 (303)

The Immune Endocannabinoid System of the Tumor Microenvironment [PDF]

International Journal of Molecular Sciences, 2020
Leukocytes are part of the tumor microenvironment (TME) and are critical determinants of tumor progression. Because of the immunoregulatory properties of cannabinoids, the endocannabinoid system (ECS) may have an important role in shaping the TME.
Kienzl, Melanie, Kargl, Julia, Schicho, Rudolf   +2 more
openaire   +2 more sources

Cancer associated fibroblast–derived CCL5 promotes hepatocellular carcinoma metastasis through activating HIF1α/ZEB1 axis

Cell Death and Disease, 2022
Cancer-associated fibroblasts (CAFs) are one of the most enriched components of Hepatocellular carcinoma (HCC) microenvironment, which are tightly related to the metastasis and invasion of HCC.
Haixu Xu, Jie Zhao, Jinping Li, Zhifeng Zhu, Zhaohai Cui, Ran Liu, Rong Lu, Zhi Yao, Qiong Xu   +8 more
doaj   +1 more source

Targeting the tumor microenvironment in colorectal peritoneal metastases

, 2020
Peritoneal metastasis (PM) occurs in approximately one in four colorectal cancer (CRC) patients. The pathophysiology of colorectal PM remains poorly characterized. Also, the efficacy of current treatment modalities, including surgery and intraperitoneal (
Ceelen, Wim, De Wever, Olivier, Heriot, Alexander G., Narasimhan, Vignesh, Ramsay, Robert G.   +4 more
core   +1 more source

Regulation of the Host Immune Microenvironment in Periodontitis and Periodontal Bone Remodeling

International Journal of Molecular Sciences, 2023
The periodontal immune microenvironment is a delicate regulatory system that involves a variety of host immune cells including neutrophils, macrophages, T cells, dendritic cells and mesenchymal stem cells. The dysfunction or overactivation of any kind of
Nannan Han, Yitong Liu, Juan Du, Junji Xu, Lijia Guo, Yi Liu   +5 more
semanticscholar   +1 more source

In the eye of the storm: T cell behavior in the inflammatory microenvironment. [PDF]

, 2013
Coordinated unfolding of innate and adaptive immunity is key to the development of protective immune responses. This functional integration occurs within the inflamed tissue, a microenvironment enriched with factors released by innate and subsequently ...
Haas, R, Marelli-Berg, F, Mauro, C
core   +1 more source

Influence of tumors on protective anti-tumor immunity and the effects of irradiation [PDF]

, 2013
Innate and adaptive immunity play important roles in the development and progression of cancer and it is becoming apparent that tumours can influence the induction of potentially protective responses in a number of ways.
Alan Graham Pockley, Gabriele eMulthoff, Gabriele eMulthoff, Gemma Ann Foulds, Gemma Ann Foulds, Jürgen eRadons, Mira eKreuzer   +6 more
core   +2 more sources

Single-cell transcriptome analysis revealed a suppressive tumor immune microenvironment in EGFR mutant lung adenocarcinoma

Journal for ImmunoTherapy of Cancer, 2022
Backgrounds Immunotherapy is less effective in patients with epidermal growth factor receptor (EGFR) mutant non-small-cell lung cancer (NSCLC). Lower programmed cell death-ligand 1 (PD-L1) expression and tumor mutation burden (TMB) are reported to be the
Lei Yang, Yun-Ting He, S. Dong, Xue-Wu Wei, Zhi-hong Chen, Bo Zhang, Weidong Chen, Xiao-Rong Yang, Fen Wang, Xue-Meng Shang, W. Zhong, Yi‐Long Wu, Qing Zhou   +12 more
semanticscholar   +1 more source

Immune microenvironment and immunotherapy for chordoma

Frontiers in Oncology
Chordoma, as a rare, low-grade malignant tumor that tends to occur in the midline of the body, grows slowly but often severely invades surrounding tissues and bones. Due to the severe invasion and damage to the surrounding tissues, chordoma is difficult to be gross totally resected in surgery, and the progression of the residual tumor is often ...
Yujia Chen, Hongwei Zhang
openaire   +3 more sources

Deficiency of NF‐Erythroid 2‐Related Factor 2 Exacerbates the Scar Through ERK Signaling Pathway

Immunity, Inflammation and Disease
Background Scar, primarily composed of poorly structured and disordered collagen, is mainly characterized by excessive fibroblast activation and abnormal collagen deposition.
Xueyuan Hao, Mengke Sun, Ruotong Wang, Hong Chen, Junkai Huang, Jing Luo, Haoyue Yu, Yingxi Li, Weibin Xing, Xiaoxia Li, Lizhi Hu   +10 more
doaj   +1 more source

Research progress in the role of β-arrestin 1 in the regulation of inflammatory response

Shanghai Jiaotong Daxue xuebao. Yixue ban
The inflammatory response is a systemic process produced by the body in response to stimulation such as infection or injury. The inflammatory response is closely related to the pathogenesis of various diseases, and plays an important role in the ...
YI Wenjing, FAN Yixuan, QIU Jiatai, FU Xiaoyan, LIU Meifang   +4 more
doaj   +1 more source