Results 71 to 80 of about 465,229 (318)

CD38 Predicts Favorable Prognosis by Enhancing Immune Infiltration and Antitumor Immunity in the Epithelial Ovarian Cancer Microenvironment

Frontiers in Genetics, 2020
The identification of predictive biomarkers and novel targets to optimize immunotherapy strategies for epithelial ovarian cancer (EOC) is urgently needed. CD38 is a multifunctional glycoprotein that acts as an ectoenzyme and immune receptor. However, the
Ying Zhu, Ying Zhu, Zhigang Zhang, Zhigang Zhang, Zhou Jiang, Yang Liu, Yang Liu, Jianwei Zhou   +7 more
doaj   +1 more source

Cancer associated fibroblast–derived CCL5 promotes hepatocellular carcinoma metastasis through activating HIF1α/ZEB1 axis

Cell Death and Disease, 2022
Cancer-associated fibroblasts (CAFs) are one of the most enriched components of Hepatocellular carcinoma (HCC) microenvironment, which are tightly related to the metastasis and invasion of HCC.
Haixu Xu, Jie Zhao, Jinping Li, Zhifeng Zhu, Zhaohai Cui, Ran Liu, Rong Lu, Zhi Yao, Qiong Xu   +8 more
doaj   +1 more source

Engaging the Immune Response to Normalize the Tumor Microenvironment [PDF]

, 2013
Solid tumors exist as heterogeneous populations comprised not only of malignant cells, but various other cell types, including cells that make up the vasculature, that can strongly influence tumorgenicity.
Sabins, Nina, Storkus, Walter
core  

Research progress in the role of β-arrestin 1 in the regulation of inflammatory response

Shanghai Jiaotong Daxue xuebao. Yixue ban
The inflammatory response is a systemic process produced by the body in response to stimulation such as infection or injury. The inflammatory response is closely related to the pathogenesis of various diseases, and plays an important role in the ...
YI Wenjing, FAN Yixuan, QIU Jiatai, FU Xiaoyan, LIU Meifang   +4 more
doaj   +1 more source

Approaches of the Innate Immune System to Ameliorate Adaptive Immunotherapy for B-Cell Non-Hodgkin Lymphoma in Their Microenvironment [PDF]

, 2021
A dominant paradigm being developed in immunotherapy for hematologic malignancies is of adaptive immunotherapy that involves chimeric antigen receptor (CAR) T cells and bispecific T-cell engagers. CAR T-cell therapy has yielded results that surpass those
Takashi Watanabe
core   +1 more source

Deficiency of NF‐Erythroid 2‐Related Factor 2 Exacerbates the Scar Through ERK Signaling Pathway

Immunity, Inflammation and Disease
Background Scar, primarily composed of poorly structured and disordered collagen, is mainly characterized by excessive fibroblast activation and abnormal collagen deposition.
Xueyuan Hao, Mengke Sun, Ruotong Wang, Hong Chen, Junkai Huang, Jing Luo, Haoyue Yu, Yingxi Li, Weibin Xing, Xiaoxia Li, Lizhi Hu   +10 more
doaj   +1 more source

Immune podocytes in the immune microenvironment of lupus nephritis (Review)

Molecular Medicine Reports, 2023
Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder caused by the loss of tolerance to endogenous nuclear antigens such as double‑stranded DNA, leading to the proliferation of T cells and subsequent activation of B cells, which results in serious organ damage and life‑threatening complications such as lupus nephritis.
Liu, Ruiling, Wen, Xiaoting, Peng, Xinyue, Zhao, Miaomiao, Mi, Liangyu, Lei, Jiamin, Xu, Ke   +6 more
openaire   +2 more sources

Immunophenotypes Based on the Tumor Immune Microenvironment Allow for Unsupervised Penile Cancer Patient Stratification [PDF]

, 2020
The tumor immune microenvironment (TIME) plays an important role in penile squamous cell carcinoma (peSCC) pathogenesis. Here, the immunophenotype of the TIME in peSCC was determined by integrating the expression patterns of immune checkpoints ...
Jiangli Lu, Yijun Zhang, Jiabin Lu, Chris Zhiyi Zhang, Keming Chen, Chengbiao Chu, Kai Yao, Yun Cao   +7 more
core   +1 more source

CD24 blunts the sensitivity of retinoblastoma to vincristine by modulating autophagy

Molecular Oncology, 2020
Retinoblastoma (RB) is the most common childhood malignant intraocular tumor. The clinical efficacy of vincristine (VCR) in the treatment of RB is severely limited by drug resistance. Here, we found that CD24, a GPI‐anchored protein, was overexpressed in
Jie Sun, Dongju Feng, Huiyu Xi, Jiajing Luo, Zewei Zhou, Qinghuai Liu, Yun Chen, Qing Shao   +7 more
doaj   +1 more source

The Immune Microenvironment of Transplant Glomerulitis

Kidney International Reports
Transplant glomerulitis is a morphological lesion seen in kidney allograft rejection that is associated with poor outcomes; however, little is known about how immune cells infiltrate and organize specifically within glomeruli.We used Co-Detection by Indexing (CODEX) multifluorescent imaging to measure 52 protein markers in a retrospective cohort of 41 ...
Bracey, Nathan A., Maltzman, Jonathan S., Long, Adrienne H., Dhanasekaran, Renu, Shankar, Vishnu, Mohsin, Azam, Kambham, Neeraja, Wernig, Gerlinde, Gentles, Andrew J., Davis, Mark M., Charu, Vivek   +10 more
openaire   +2 more sources