Results 91 to 100 of about 2,850,822 (303)

Tumour invasiveness, the local and systemic environment and the basis of staging systems in colorectal cancer [PDF]

, 2017
background: The present study aimed to examine the relationship between tumour invasiveness (T stage), the local and systemic environment and cancer-specific survival (CSS) of patients with primary operable colorectal cancer.
A Chrysanthopoulou, A Huijbers, AJ Munro, B Mlecnik, C Guastadisegni, C S D Roxburgh, CE Dukes, CH Richards, D C McMillan, D Church, D Hanahan, DC McMillan, F Pages, F Pages, FA Sinicrope, G Bindea, GJ Guthrie, H Ueno, H Ueno, H van Wyk, HC van Wyk, ID Nagtegaal, J Edwards, J Galon, J Guinney, J H Park, J Li, JB O'Connell, JH Park, JH Park, JH Park, JH Park, K Birkenkamp-Demtroder, K Klintrup, L De Smedt, LL Gunderson, LS Rozek, MJ Pollheimer, P G Horgan, P Quirke, R Salazar, S Ogino, SA Vayrynen, SS McAllister, T Kantola, VH Koelzer, W De Roock, WE Mesker   +47 more
core   +1 more source

Revisiting of TAMs in tumor immune microenvironment: Insight from NF-κB signaling pathway.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2023
Tumor-associated macrophages (TAMs) are key components of tumor immune microenvironment and play a dual role in promoting tumor growth and anti-tumor immunity. Therefore, regulating TAMs has become a promising method in cancer immunotherapy.
Rui He, Yan-Li He, R. Du, Chenxin Liu, Ze-ran Chen, A. Zeng, Linjiang Song   +6 more
semanticscholar   +1 more source

The Immune Microenvironment of Transplant Glomerulitis

Kidney International Reports
Transplant glomerulitis is a morphological lesion seen in kidney allograft rejection that is associated with poor outcomes; however, little is known about how immune cells infiltrate and organize specifically within glomeruli.We used Co-Detection by Indexing (CODEX) multifluorescent imaging to measure 52 protein markers in a retrospective cohort of 41 ...
Bracey, Nathan A., Maltzman, Jonathan S., Long, Adrienne H., Dhanasekaran, Renu, Shankar, Vishnu, Mohsin, Azam, Kambham, Neeraja, Wernig, Gerlinde, Gentles, Andrew J., Davis, Mark M., Charu, Vivek   +10 more
openaire   +2 more sources

Tumor necrosis factor receptor 2 promotes endothelial cell-mediated suppression of CD8+ T cells through tuning glycolysis in chemoresistance of breast cancer

Journal of Translational Medicine
Background T cells play a pivotal role in chemotherapy-triggered anti-tumor effects. Emerging evidence underscores the link between impaired anti-tumor immune responses and resistance to paclitaxel therapy in triple-negative breast cancer (TNBC).
Yu Hu, Xiaohan Lou, Kaili Zhang, Longze Pan, Yueyue Bai, Linlin Wang, Ming Wang, Yan Yan, Jiajia Wan, Xiaohan Yao, Xixi Duan, Chen Ni, Zhihai Qin   +12 more
doaj   +1 more source

Roles of tumor suppressors in regulating tumor-associated inflammation. [PDF]

, 2014
Loss or silencing of tumor suppressors (TSs) promotes neoplastic transformation and malignant progression. To date, most work on TS has focused on their cell autonomous effects.
Karin, M, Yang, L
core   +1 more source

Protein S-palmitoylation modification: implications in tumor and tumor immune microenvironment

Frontiers in Immunology
Protein S-palmitoylation is a reversible post-translational lipid modification that involves the addition of a 16-carbon palmitoyl group to a protein cysteine residue via a thioester linkage.
Yijiao Chen, Yongsheng Li, Lei Wu
semanticscholar   +1 more source

Effect of gut flora mediated‐bile acid metabolism on intestinal immune microenvironment

Immunology, 2023
According to reports, gut microbiota and metabolites regulate the intestinal immune microenvironment. In recent years, an increasing number of studies reported that bile acids (BAs) of intestinal flora origin affect T helper cells and regulatory T cells (
Yan Zhang, Xu Gao, Shuochen Gao, Yang Liu, Wenkang Wang, Yudi Feng, Liping Pei, Zhenqiang Sun, Lin Liu, Chengzeng Wang   +9 more
semanticscholar   +1 more source

Anticancer Effects of Amlodipine Alone or in Combination With Gefitinib in Non-Small Cell Lung Cancer

Frontiers in Pharmacology, 2022
Amlodipine is a Ca2+ channel blocker commonly used to cardiovascular diseases such as hypertension and angina; however, its anticancer effects in lung cancer A549 cells remain unknown. In the present study, we explored the antitumor effects and molecular
Bingjie Fu, Xiaojing Dou, Miao Zou, Hao Lu, Kaixuan Wang, Qingxia Liu, Yao Liu, Wei Wang, Meihua Jin, Dexin Kong   +9 more
doaj   +1 more source

Potential role of immunotherapy in advanced non-small-cell lung cancer [PDF]

, 2016
Immuno checkpoint inhibitors have ushered in a new era with respect to the treatment of advanced non-small-cell lung cancer. Many patients are not suitable for treatment with epidermal growth factor receptor tyrosine kinase inhibitors (eg, gefitinib ...
Antoniou, Georgios, Catarina, Paulo Esrom, De Mello, Ramon Andrade, Nadine, Sara, Veloso, Ana Flavia   +4 more
core   +3 more sources

The effects of metabolism on the immune microenvironment in colorectal cancer

Cell Death Discovery
Colorectal cancer (CRC) is a malignancy that is widely prevalent worldwide. Due to its unsatisfactory treatment outcome and extremely poor prognosis, many studies on the molecular mechanisms and pathological mechanisms of CRC have been published in ...
Xingzhao Chen, Zhiyuan Ma, Zhiqiang Yi, Enqin Wu, Zhengye Shang, Biguang Tuo, Taolang Li, Xuemei Liu   +7 more
semanticscholar   +1 more source