Results 101 to 110 of about 2,850,822 (303)

Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor immune microenvironment

Cell Host and Microbe, 2013
SUMMARY Increasing evidence links the gut microbiota with colorectal cancer. Metagenomic analyses indicate that commensal Fusobacterium spp. are associated with human colorectal carcinoma but whether this is an indirect or causal link remains unclear. We
A. Kostic, Eunyoung Chun, Lauren Robertson, J. Glickman, C. Gallini, M. Michaud, T. Clancy, D. Chung, P. Lochhead, G. Hold, E. El-Omar, D. Brenner, C. Fuchs, M. Meyerson, W. Garrett   +14 more
semanticscholar   +1 more source

Unveiling the Immune Microenvironment’s Role in Breast Cancer: A Glimpse into Promising Frontiers

International Journal of Molecular Sciences, 2023
Breast cancer (BC), one of the most widespread and devastating diseases affecting women worldwide, presents a significant public health challenge. This review explores the emerging frontiers of research focused on deciphering the intricate interplay ...
Amalia Kotsifaki, N. Alevizopoulos, Vassiliki Dimopoulou, A. Armakolas   +3 more
semanticscholar   +1 more source

Extracellular vesicles in the tumor immune microenvironment

Cancer Letters, 2021
Extracellular vesicles (EVs) have gained significant attention in recent decades as major mediators of intercellular communication that are involved in various essential physiological and pathological processes. They are secreted by almost all cell types and carry bioactive materials, such as proteins, lipids and nucleic acids, that can be transmitted ...
Pei-pei Hou, Hang-zi Chen
openaire   +2 more sources

Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice

Nature Communications, 2020
The use of tumour exosome-activated dendritic cell (DC) immunotherapy shows promise for the treatment of large established tumours. Here, the authors generate alarmin HMGN1-attached tumour exosomes which significantly improve therapy efficacy by boosting
Bingfeng Zuo, Han Qi, Zhen Lu, Lu Chen, Bo Sun, Rong Yang, Yang Zhang, Zhili Liu, Xianjun Gao, Abin You, Li Wu, Renwei Jing, Qibing Zhou, HaiFang Yin   +13 more
doaj   +1 more source

A Rosetta Stone for Breast Cancer: Prognostic Value and Dynamic Regulation of Neutrophil in Tumor Microenvironment

Frontiers in Immunology, 2020
Increasing evidence has revealed that the initiation and progression of breast cancer are greatly affected by the immune environment. Neutrophils are the most abundant leucocytes in circulation and act as the spearhead in inflammation, including in ...
Wei Zhang, Yimin Shen, Yimin Shen, Huanhuan Huang, Huanhuan Huang, Sheng Pan, Jingxin Jiang, Jingxin Jiang, Wuzhen Chen, Wuzhen Chen, Ting Zhang, Chao Zhang, Chao Ni, Chao Ni   +13 more
doaj   +1 more source

RhoB affects colitis through modulating cell signaling and intestinal microbiome

Microbiome, 2022
Background The pathogenesis of inflammatory bowel diseases (IBD) is multifactorial, and diagnostic and treatment strategies for IBD remain to be developed. RhoB regulates multiple cell functions; however, its role in colitis is unexplored.
Jianming Yang, Geng Pei, Xuan Sun, Yawen Xiao, Chunhui Miao, Lu Zhou, Bangmao Wang, Liu Yang, Mingyu Yu, Zhi-Song Zhang, Evan T. Keller, Zhi Yao, Quan Wang   +12 more
doaj   +1 more source

Dickkopf-related protein 1 (Dkk1) regulates the accumulation and function of myeloid derived suppressor cells in cancer [PDF]

, 2016
Tumor–stroma interactions contribute to tumorigenesis. Tumor cells can educate the stroma at primary and distant sites to facilitate the recruitment of heterogeneous populations of immature myeloid cells, known as myeloid-derived suppressor cells (MDSCs).
Ali Zamani, Andrea Wang-Gillam, Aude-Hélène Capietto, Barcellos-Hoff, Biancamaria Ricci, Bindea, Capietto, David B. Bumpass, David G. DeNardo, Fowler, Gabitass, Gabrilovich, Gabrilovich, Galon, Hamanishi, Katherine Weilbaecher, Li, Liu, Lucia D’Amico, MacDonald, Mace, Mahmoud, Melissa Meyer, Mitchem, Mundy-Bosse, Pinzone, Porembka, Roberta Faccio, Räsänen, Sahil Mahajan, Schreiber, Sheila A. Stewart, Tian, Trikha, Weilbaecher, Xinming Su, Yaccoby, Yamabuki, Yang, Zhang, Zhang, Zheng, Zhengfeng Yang, Zhu   +43 more
core   +2 more sources

Zinc-based Polyoxometalate Nanozyme Functionalized Hydrogels for optimizing the Hyperglycemic-Immune Microenvironment to Promote Diabetic Wound Regeneration

Journal of Nanobiotechnology
In diabetic wounds, hyperglycemia-induced cytotoxicity and impaired immune microenvironment plasticity directly hinder the wound healing process. Regulation of the hyperglycemic microenvironment and remodeling of the immune microenvironment are crucial ...
Chaoyu Pu, Yong Wang, Honglin Xiang, Jiangtao He, Qiyuan Sun, Yuan Yong, Lu Chen, Ke Jiang, Hanfeng Yang, Yuling Li   +9 more
semanticscholar   +1 more source

Allosteric Regulation of IGF2BP1 as a Novel Strategy for the Activation of Tumor Immune Microenvironment

ACS Central Science, 2022
Tumor immune microenvironment (TIME) regulators are promising cancer immunotherapeutic targets. IGF2BP1, as a crucial N6-methyladenosine (m6A) reader protein, recognizes m6A target transcripts, ultimately leading to cancer development. However, currently,
Yang Liu, Qiang Guo, Heng Yang, Xiao-Wen Zhang, Na Feng, Jingkang Wang, Ting-ting Liu, K. Zeng, P. Tu   +8 more
semanticscholar   +1 more source

Mapping the BCSC-1 interactome in breast cancer

Scientific Reports
BCSC-1 (breast cancer suppressor candidate-1), the official gene symbol VWA5A (von Willebrand factor A domain containing 5 A), is downregulated in a variety of cancer types including breast cancer.
Yuan Ma, Qingchen Zhang, Jiyu Ju, Xiaoyan Fu, Hongbin Du, Pei Zhong, Shengyan Zhang, Zhuowei Li, Yuchen Liu, Lei Gong, Chunling Zhao   +10 more
doaj   +1 more source