Antiangiogenic therapy reverses the immunosuppressive breast cancer microenvironment
Biomarker Research, 2021 Tumor angiogenesis induces local hypoxia and recruits immunosuppressive cells, whereas hypoxia subsequently promotes tumor angiogenesis. Immunotherapy efficacy depends on the accumulation and activity of tumor-infiltrating immune cells (TIICs ...
Wuzhen Chen +7 more
doaj +1 more source
Engineered Tumor-Targeted T Cells Mediate Enhanced Anti-Tumor Efficacy Both Directly and through Activation of the Endogenous Immune System. [PDF]
, 2018 Chimeric antigen receptor (CAR) T cell therapy has proven clinically beneficial against B cell acute lymphoblastic leukemia and non-Hodgkin's lymphoma. However, suboptimal clinical outcomes have been associated with decreased expansion and persistence of
Avanzi, Mauro P +10 more
core +1 more source
, 2019 Cancer cells can acquire a spectrum of stable hybrid epithelial/mesenchymal (E/M) states during epithelial-mesenchymal transition (EMT). Cells in these hybrid E/M phenotypes often combine epithelial and mesenchymal features and tend to migrate ...
Bocci, Federico +7 more
core +1 more source
Biomaterial-based ligand presentation to induce notch signaling in vitro [PDF]
, 2013 T cell adoptive transfer is an important procedure in immunotherapy. In immunocompromised patients, T cells may need to be developed from stem cells, requiring the induction of Notch signaling events responsible for native T cell differentiation in the ...
Mehta, Naveen
core +1 more source
917 Reversing the immune-excluded (“cold”) tumor immune microenvironment in oral squamous cell carcinoma [PDF]
, 2022 Yewen Shi +8 more
openalex +1 more source
Modulation of innate immunity in the tumor microenvironment [PDF]
Cancer Immunology, Immunotherapy, 2016 A recent report from the Center for Disease Control identified melanoma as being among the highest causes of cancer-related mortalities in the USA. While interventions such as checkpoint blockade have made substantial impact in terms of improving response rates and overall survival, a significant number of patients fail to respond to treatment or ...
Elena, Gonzalez-Gugel +2 more
openaire +2 more sources
miR-128 Regulates Tumor Cell CD47 Expression and Promotes Anti-tumor Immunity in Pancreatic Cancer
Frontiers in Immunology, 2020 Pancreatic adenocarcinoma (PDAC) is a highly fatal disease worldwide. MicroRNAs (miRNAs) could regulate the protein-coding RNAs related to tumor growth, invasion, and immune evasion.
Qing Xi +10 more
doaj +1 more source
Src as the link between inflammation and cancer. [PDF]
, 2013 Although a causal link between chronic inflammation and cancer has been established, the exact molecular mechanism linking inflammation to cancer remains largely unknown.
Andrzej ePtasznik +4 more
core +2 more sources
1424 m6A regulators related to molecular feature, immune microenvironment and prognosis in lung adenocarcinoma [PDF]
, 2022 Zhibo Tan +12 more
openalex +1 more source
307 IL12 genetically engineered myeloid cells effectively target the myeloid-enriched tumor and metastatic microenvironment in an immune-competent murine model of osteosarcoma [PDF]
, 2022 Kristin Wessel +4 more
openalex +1 more source