Frequency over function : raised levels of CD127low/- regulatory T cells in the tumour microenvironment compared with the periphery of head and neck cancer patients [PDF]
, 2014 Objective: Regulatory T cells (Tregs) are known to infiltrate the tumour microenvironment of many cancers, including head and neck malignancies, and are thought to contribute to the host's impaired anti-tumour immune response.
Drennan, Samantha +3 more
core +1 more source
Sexual dimorphism in cancer: molecular mechanisms and precision oncology perspectives
Biology of Sex DifferencesSex differences play a crucial role in determining tumor incidence, treatment sensitivity, and prognosis among men and women. However, current clinical cancer treatment strategies fail to account for these differences.
Zhen Wang +4 more
doaj +1 more source
陆军军医大学学报Objective To investigate the effect of Saikosaponin A (SSA) on the differentiation, apoptosis and function of mouse bone marrow derived macrophages (BMDM)-derived M1/M2 macrophages, and to explore its molecular mechanism.
CUI Zhao, SHU Yating, LEI Fan
doaj +1 more source
Signal transduction and activator of transcription-3 (STAT3) in patients with colorectal cancer: associations with the phenotypic features of the tumour and host [PDF]
, 2017 Purpose: In patients with colorectal cancer (CRC), a high-density local inflammatory infiltrate response is associated with improved survival, whereas elevated systemic inflammatory responses are associated with poor survival.
Clark, Jennifer +7 more
core +1 more source
Cell, 2018 The immune system is critical in modulating cancer progression, but knowledge of immune composition, phenotype, and interactions with tumor is limited. We used Multiplexed Ion Beam Imaging by Time-of-Flight (MIBI-TOF) to simultaneously quantify in-situ ...
Leeat Keren +11 more
semanticscholar +1 more source
VIP treatment prevents embryo resorption by modulating efferocytosis and activation profile of maternal macrophages in the CBAxDBA resorption prone model [PDF]
, 2016 Successful embryo implantation occurs followed by a local pro-inflammatory response subsequently shifted toward a tolerogenic one. VIP (vasoactive intestinal peptide) has embryotrofic, anti-inflammatory and tolerogenic effects.
Calo, Guillermina +7 more
core +1 more source
Polymorphisms in immunosuppression-related genes are associated with AML
Frontiers in ImmunologyBackgroundAcute myeloid leukemia (AML) is a hematologic malignancy with poor overall survival (OS). The immunosuppressive microenvironment significantly impacts AML development and chemoresistance.
Mingying Li +21 more
doaj +1 more source
Role of Noncoding RNAs in the Tumor Immune Microenvironment of Hepatocellular Carcinoma [PDF]
, 2023 Yue Lv, Zhen Wang, Kefei Yuan
openalex +1 more source