Results 141 to 150 of about 1,580,087 (314)

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Klf9 Loss of Function Protects Against Glucocorticoids Induced Skeletal Muscle Wasting

Journal of Cachexia, Sarcopenia and Muscle
Background Glucocorticoids (GCs) are the most important and frequently used class of anti‐inflammatory drugs. However, the mechanisms underlying excessive glucocorticoid‐mediated induction of muscle atrophy remain incompletely understood.
Yujie Zhang, Jingran Hao, Yueyao Feng, Tongtong Qiu, Jinjin Wu, Xuenan Zhou, Heng Fan, Yongsheng Chang   +7 more
doaj   +1 more source

Impact of single nucleotide polymorphisms of immunomodulatory factors on treatment response and prognosis in acute myeloid leukemia

Frontiers in Immunology
BackgroundAcute myeloid leukemia (AML) is a hematologic malignancy characterized by poor overall survival (OS). The impaired function, altered phenotype, and abnormal distribution of T cells create an immunosuppressive microenvironment in AML, affecting ...
Mingying Li, Mingying Li, Tao Sun, Tao Sun, Mengyuan Chang, Mengyuan Chang, Tingting Liu, Tingting Liu, Lei Feng, Lei Feng, Di Zhang, Di Zhang, Yuyan Wu, Yuyan Wu, Yuechan Ma, Yuechan Ma, Huixian Ma, Guangqiang Meng, Guangqiang Meng, Chunyan Ji, Chunyan Ji, Jingjing Ye, Jingjing Ye   +22 more
doaj   +1 more source

A digest on the role of the tumor microenvironment in gastrointestinal cancers

, 2010
Experimental studies and analyses of clinical material have convincingly demonstrated that tumor formation and progression occurs through a concerted action of malignant cells and the surrounding microenvironment of the tumor stroma.
Augsten, M,, Hägglöf, Christina,, Pena, C, Ostman, A, Hagglof, C, Peña, Cristina,, Augsten, Martin,, Ostman, Arne,   +7 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Screening and functional validation of key genes in Helicobacter Pylori-induced macrophage M1 polarization: role in migraine-associated functional dyspepsia

Frontiers in Immunology
BackgroundMigraine, a prevalent and debilitating neurovascular disorder, frequently co-occurs with functional dyspepsia. Emerging evidence suggests that Helicobacter pylori (H. pylori) infection may contribute to both conditions via neuroimmune pathways,
Nengjin Sun, Nengjin Sun, Kaile Wang, Kaile Wang, Jianli Gou, Jianli Gou, Panpan Li, Panpan Li, Xiaoyan Fu, Wenjing Shi, Jing Li, Miao Xiang, Miao Xiang, Shenglin Sun, Zihan Sun, Shujuan Liang, Yuying Zhang, Hongyan Wang, Hongyan Wang   +18 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang, Dongxu Zhang, Dongyuan Liu, Da Lin, Hao Wang   +4 more
wiley   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source