Results 151 to 160 of about 465,229 (318)

Screening and functional validation of key genes in Helicobacter Pylori-induced macrophage M1 polarization: role in migraine-associated functional dyspepsia

Frontiers in Immunology
BackgroundMigraine, a prevalent and debilitating neurovascular disorder, frequently co-occurs with functional dyspepsia. Emerging evidence suggests that Helicobacter pylori (H. pylori) infection may contribute to both conditions via neuroimmune pathways,
Nengjin Sun, Nengjin Sun, Kaile Wang, Kaile Wang, Jianli Gou, Jianli Gou, Panpan Li, Panpan Li, Xiaoyan Fu, Wenjing Shi, Jing Li, Miao Xiang, Miao Xiang, Shenglin Sun, Zihan Sun, Shujuan Liang, Yuying Zhang, Hongyan Wang, Hongyan Wang   +18 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Disulfidptosis links the pathophysiology of ulcerative colitis and immune infiltration in colon adenocarcinoma

Scientific Reports
Ulcerative colitis (UC), a chronic inflammatory bowel disease, significantly increases the risk of colon adenocarcinoma (COAD). Disulfidptosis, a novel form of programmed cell death, has been implicated in various diseases, including UC.
Chenhao Jiang, Teng Yue, Ziyao Jia, Lili Song, Xiaohang Zeng, Ziyu Bao, Xinying Li, Zhuang Cui, Wenyi Mi, Qianqian Li   +9 more
doaj   +1 more source

Progranulin inhibits autophagy to facilitate intracellular colonization of Helicobacter pylori through the PGRN/mTOR/DCN axis in gastric epithelial cells

Frontiers in Cellular and Infection Microbiology
Helicobacter pylori (H. pylori) infection is the primary risk factor for the progress of gastric diseases. The persistent stomach colonization of H. pylori is closely associated with the development of gastritis and malignancies. Although the involvement
Linlin Liu, Linlin Liu, Miao Xiang, Miao Xiang, Jiaqi Zhou, Jiaqi Zhou, Zongjiao Ren, Zongjiao Ren, Wenjing Shi, Xianhong Du, Xiaoyan Fu, Panpan Li, Panpan Li, Hongyan Wang, Hongyan Wang   +14 more
doaj   +1 more source

Immune Regulation and Immune Therapy in Melanoma: Review with Emphasis on CD155 Signalling [PDF]

Melanoma is commonly diagnosed in a younger population than most other solid malignancies and, in Australia and most of the world, is the leading cause of skin-cancer-related death.
Haakan Jakobsson, Su-Ho Park, Andreas Möller, Li-Ying Wu, Mark Shackleton   +4 more
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Signaling by Type I Interferons in Immune Cells: Disease Consequences [PDF]

This review addresses interferon (IFN) signaling in immune cells and the tumor microenvironment (TME) and examines how this affects cancer progression.
Fish, Eleanor N., Markella Zannikou, Leonidas C. Platanias, Platanias, Leonidas C., Eleanor N. Fish, Zannikou, Markella   +5 more
core   +2 more sources