Results 151 to 160 of about 2,850,822 (303)

Resveratrol-Loaded Nanoplatform Rsv@Dtpf Promote Alveolar Bone Regeneration in Ovx Rat Through Remodeling Bone-Immune Microenvironment

, 2023
Haoran Peng, Xinyi Qiu, Mingyue Cheng, Yue Zhao, Lutong Song, Bijun Zhu, Yuyang Li, Chao Liu, Shuangshuang Ren, Leiying Miao   +9 more
openalex   +1 more source

222-E Integrative spatial multi-omics analysis of NSCLC tumor microenvironment identifies key features associated with response to immune checkpoint inhibitor therapy [PDF]

, 2023
Steve Hamel, Marie Cumberbatch, Alexandro E. Trevino, Ying Qu, Milan Bhagat, Meredith Manuel, Aaron T. Mayer   +6 more
openalex   +1 more source

Klf9 Loss of Function Protects Against Glucocorticoids Induced Skeletal Muscle Wasting

Journal of Cachexia, Sarcopenia and Muscle
Background Glucocorticoids (GCs) are the most important and frequently used class of anti‐inflammatory drugs. However, the mechanisms underlying excessive glucocorticoid‐mediated induction of muscle atrophy remain incompletely understood.
Yujie Zhang, Jingran Hao, Yueyao Feng, Tongtong Qiu, Jinjin Wu, Xuenan Zhou, Heng Fan, Yongsheng Chang   +7 more
doaj   +1 more source

Impact of single nucleotide polymorphisms of immunomodulatory factors on treatment response and prognosis in acute myeloid leukemia

Frontiers in Immunology
BackgroundAcute myeloid leukemia (AML) is a hematologic malignancy characterized by poor overall survival (OS). The impaired function, altered phenotype, and abnormal distribution of T cells create an immunosuppressive microenvironment in AML, affecting ...
Mingying Li, Mingying Li, Tao Sun, Tao Sun, Mengyuan Chang, Mengyuan Chang, Tingting Liu, Tingting Liu, Lei Feng, Lei Feng, Di Zhang, Di Zhang, Yuyan Wu, Yuyan Wu, Yuechan Ma, Yuechan Ma, Huixian Ma, Guangqiang Meng, Guangqiang Meng, Chunyan Ji, Chunyan Ji, Jingjing Ye, Jingjing Ye   +22 more
doaj   +1 more source

Screening and functional validation of key genes in Helicobacter Pylori-induced macrophage M1 polarization: role in migraine-associated functional dyspepsia

Frontiers in Immunology
BackgroundMigraine, a prevalent and debilitating neurovascular disorder, frequently co-occurs with functional dyspepsia. Emerging evidence suggests that Helicobacter pylori (H. pylori) infection may contribute to both conditions via neuroimmune pathways,
Nengjin Sun, Nengjin Sun, Kaile Wang, Kaile Wang, Jianli Gou, Jianli Gou, Panpan Li, Panpan Li, Xiaoyan Fu, Wenjing Shi, Jing Li, Miao Xiang, Miao Xiang, Shenglin Sun, Zihan Sun, Shujuan Liang, Yuying Zhang, Hongyan Wang, Hongyan Wang   +18 more
doaj   +1 more source

Disulfidptosis links the pathophysiology of ulcerative colitis and immune infiltration in colon adenocarcinoma

Scientific Reports
Ulcerative colitis (UC), a chronic inflammatory bowel disease, significantly increases the risk of colon adenocarcinoma (COAD). Disulfidptosis, a novel form of programmed cell death, has been implicated in various diseases, including UC.
Chenhao Jiang, Teng Yue, Ziyao Jia, Lili Song, Xiaohang Zeng, Ziyu Bao, Xinying Li, Zhuang Cui, Wenyi Mi, Qianqian Li   +9 more
doaj   +1 more source

Progranulin inhibits autophagy to facilitate intracellular colonization of Helicobacter pylori through the PGRN/mTOR/DCN axis in gastric epithelial cells

Frontiers in Cellular and Infection Microbiology
Helicobacter pylori (H. pylori) infection is the primary risk factor for the progress of gastric diseases. The persistent stomach colonization of H. pylori is closely associated with the development of gastritis and malignancies. Although the involvement
Linlin Liu, Linlin Liu, Miao Xiang, Miao Xiang, Jiaqi Zhou, Jiaqi Zhou, Zongjiao Ren, Zongjiao Ren, Wenjing Shi, Xianhong Du, Xiaoyan Fu, Panpan Li, Panpan Li, Hongyan Wang, Hongyan Wang   +14 more
doaj   +1 more source

Oncogenic senescence: a multi-functional perspective. [PDF]

, 2017
Cellular senescence is defined as an irreversible growth arrest with the acquisition of a distinctive secretome. The growth arrest is a potent anticancer mechanism whereas the secretome facilitates wound healing, tissue repair, and development.
Alimirah, Fatouma, Baker, Darren J, Campisi, Judith, Hildesheim, Jeffrey, van Deursen, Jan M   +4 more
core  

Cancer vaccines: uses of HLA transgenic mice compared to genetically modified mice [PDF]

, 2008
Many tumor antigens have been identified that can be targeted by the immune system. Animal models that have been genetically modified to express human HLA molecules instead of their own MHC antigens have shown to be valuable in the discovery of peptides ...
McArdle, SE
core  

Chronic Stress‐Induced and Tumor Derived SP1+ Exosomes Polarizing IL‐1β+ Neutrophils to Increase Lung Metastasis of Breast Cancer

Advanced Science
Chronic stress can significantly promote breast cancer progression. When exposed to chronic stress, exosomes released from neural and neuroendocrine cells in the central nervous system are enhanced and modified.
Leyi Zhang, Jun Pan, Meijun Wang, Jini Yang, Sangsang Zhu, Lili Li, Xiaoxiao Hu, Zhen Wang, Liwei Pang, Peng Li, Fang Jia, Guohong Ren, Yi Zhang, Danying Xu, Fuming Qiu, Jian Huang   +15 more
doaj   +1 more source