Results 81 to 90 of about 1,580,087 (314)

CXCL8 Up-Regulated LSECtin through AKT Signal and Correlates with the Immune Microenvironment Modulation in Colon Cancer

, 2022
Background: The role of CXCL8 and LSECtin in colon cancer liver metastasis and immune checkpoint inhibitors (ICIs) treatment effect were widely recognized. However, the regulatory role of CXCL8 on LSECtin is still unclear.
Jian Dong, Shen, Tao, Shaojun Fang, Zhenhui Li, Yangwei Zhang, Zhibin Yang, Cheng, Xianshuo, Li, Yunfeng, Dong, Jian, Xueyan Pan, Zhengfeng Yin, Li, Zhenhui, Tao Shen, Yin, Zhengfeng, Yunfeng Li, Xianshuo Cheng, Zhang, Yangwei, Pan, Xueyan, Tian, Linghan, Yang, Zhibin, Linghan Tian, Fang, Shaojun   +21 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Pentose phosphate pathway fuels cGAS-STING signalling to boost function of intratumoral conventional dendritic cells

Nature Communications
Tumors employ diverse mechanisms to impair conventional dendritic cell (cDC) function within the tumor microenvironment, yet the underlying processes remain unclear.
Ben Liu, Zhonglei Geng, Yujie Huang, Yaqing Yuan, Tongchang Xu, Yi Zhu, Jingwen Zhang, Zhekai Luo, Sijia Zhang, Rui Ding, Ranran Tang, Yun Li, Zhilin Hu   +12 more
doaj   +1 more source

Metabolites and Immune Response in Tumor Microenvironments

, 2023
The remodeled cancer cell metabolism affects the tumor microenvironment and promotes an immunosuppressive state by changing the levels of macro- and micronutrients and by releasing hormones and cytokines that recruit immunosuppressive immune cells. Novel
Salvatore Cortellino, Valter D. Longo
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Immune Microenvironment Characteristics of Urachal Carcinoma and Its Implications for Prognosis and Immunotherapy

, 2022
Urachal carcinoma (UrC) is an exceedingly rare tumor and lacks effective treatment. Herein, we characterized an immune microenvironment characteristic of UrC in detail and identified its implications for prognosis and immunotherapy.
Jierong Chen, Xinke Zhang, Run-Cong Nie, Chunhua Qu, Muyan Cai, Yuanzhong Yang, Suijing Wang   +6 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Dual-Functional Self-Assembled Nanoparticles for Synergistic Photodynamic Therapy and Antimetastatic Treatment of Colorectal Cancer

Pharmaceutics
Background: Colorectal cancer (CRC) is a major clinical challenge due to high metastasis and therapy resistance. Photodynamic therapy (PDT) offers precise tumor ablation but lacks sustained anti-metastatic activity.
Yixuan Li, Haokun Zhang, Tinghai Xu, Ruifeng Jiang, Yubin Zhu, Dong Wang, Peng Xu   +6 more
doaj   +1 more source

Tumor Immune Microenvironment in Lymphoma: Focus on Epigenetics

, 2022
Lymphoma is a neoplasm arising from B or T lymphocytes or natural killer cells characterized by clonal lymphoproliferation. This tumor comprises a diverse and heterogeneous group of malignancies with distinct clinical, histopathological, and molecular ...
Daniel J. García-Domínguez, Jiménez-Cortegana, Carlos, Sánchez Margalet, Víctor, Carlos Jiménez-Cortegana, Palazón-Carrión, Natalia, Víctor Sánchez-Margalet, Lourdes Hontecillas-Prieto, Cruz Merino, Luis de la, Hontecillas-Prieto, Lourdes, Natalia Palazón-Carrión, García-Domínguez, Daniel J., Luis de la Cruz-Merino, Jiménez Cortegana, Carlos, Hontecillas Prieto, Lourdes, Palazón Carrión, Natalia, de la Cruz-Merino, Luis, García-Domínguez, Daniel J, Sánchez-Margalet, Víctor   +17 more
core   +1 more source