Results 81 to 90 of about 465,229 (318)

Tumor immune microenvironment (TIME) to enhance antitumor immunity

European Journal of Medical Research, 2023
AbstractThe tumor microenvironment is a result of dynamic interaction between different cellular and non-cellular components. In its essence it is not a solo performer, but an ensemble of performers that includes cancer cells, fibroblasts, myo-fibroblasts, endothelial cells and immune cells.
Sajin Rajbhandary, Hari Dhakal, Sudip Shrestha   +2 more
openaire   +3 more sources

In the eye of the storm: T cell behavior in the inflammatory microenvironment. [PDF]

, 2013
Coordinated unfolding of innate and adaptive immunity is key to the development of protective immune responses. This functional integration occurs within the inflamed tissue, a microenvironment enriched with factors released by innate and subsequently ...
Marelli-Berg, F, Mauro, Claudio; id_orcid, Haas, R, Haas, Robert, Mauro, C, Marelli-Berg, Federica M   +5 more
core  

The Role of Neural Signaling in the Pancreatic Cancer Microenvironment [PDF]

, 2022
Pancreatic cancer is one of the most lethal malignant diseases. Various cells in the tumor microenvironment interact with tumor cells and orchestrate to support tumor progression.
Ryota Takahashi, Takahashi, Ryota, Fujishiro, Mitsuhiro, Mitsuhiro Fujishiro, Hideaki Ijichi, Ijichi, Hideaki   +5 more
core   +1 more source

Zinc-copper bimetallic nanoplatforms trigger photothermal-amplified cuproptosis and cGAS-STING activation for enhancing triple-negative breast cancer immunotherapy

Journal of Nanobiotechnology
Triple-negative breast cancer (TNBC) is characterized by high rates of metastasis and recurrence, along with a low sensitivity to immunotherapy, resulting in a paucity of effective therapeutic strategies.
Bangyi Zhou, Mengyao Chen, Zhixing Hao, Lili Li, Yixin Zhang, Baoru Fang, Miner Shao, Guohong Ren, Ke Wang, Huiying Liu, Jingxuan Zhu, Xinyi Zhang, Shuyan Yuan, I Sitou, Jing Zhao, Jian Huang, Zhangsen Yu, Fuming Qiu   +17 more
doaj   +1 more source

Immune microenvironment and immunotherapy for chordoma

Frontiers in Oncology
Chordoma, as a rare, low-grade malignant tumor that tends to occur in the midline of the body, grows slowly but often severely invades surrounding tissues and bones. Due to the severe invasion and damage to the surrounding tissues, chordoma is difficult to be gross totally resected in surgery, and the progression of the residual tumor is often ...
Yujia Chen, Hongwei Zhang
openaire   +3 more sources

The significance of immune microenvironment in patients with endometriosis

Romanian Journal of Morphology and Embryology, 2023
Endometriosis represents an estrogen-dependent disease of the female reproductive system and intra- and extraperitoneal regions, with chronic feature. Currently, immune cells, such as macrophages and lymphocytes, are considered to play a pivotal role in angiogenesis and invasion of endometriotic cells through matrix remodeling.
Păvăleanu, Ioana, Balan, Raluca Anca, Grigoraş, Adriana, Balan, Teodora Ana, Amălinei, Cornelia   +4 more
openaire   +2 more sources

The Glioma Immune Landscape: A Double-Edged Sword for Treatment Regimens [PDF]

, 2023
Immune cells constitute a major part of the tumor microenvironment, thereby playing an important role in regulating tumor development. They interact with tumor cells, resulting in the suppression or promotion of glioma development.
Sukrit Mahajan, Mirko H. H. Schmidt, Ulrike Schumann   +2 more
core   +1 more source

Tumor necrosis factor receptor 2 promotes endothelial cell-mediated suppression of CD8+ T cells through tuning glycolysis in chemoresistance of breast cancer

Journal of Translational Medicine
Background T cells play a pivotal role in chemotherapy-triggered anti-tumor effects. Emerging evidence underscores the link between impaired anti-tumor immune responses and resistance to paclitaxel therapy in triple-negative breast cancer (TNBC).
Yu Hu, Xiaohan Lou, Kaili Zhang, Longze Pan, Yueyue Bai, Linlin Wang, Ming Wang, Yan Yan, Jiajia Wan, Xiaohan Yao, Xixi Duan, Chen Ni, Zhihai Qin   +12 more
doaj   +1 more source

Hypoxia, a key factor in the immune microenvironment

Biomedicine & Pharmacotherapy, 2022
The physical and chemical pressures in the tumor microenvironment (TME) play an important role in tumor development by regulating stromal elements, including immune cells. Hypoxia can induce a cascade of events in tumor initiation and development via immune regulation.
Jingyao, Hu, Xinyu, Li, Liang, Yang, Hangyu, Li   +3 more
openaire   +2 more sources

Genetic Alterations Impact Immune Microenvironment Interactions in Follicular Lymphoma. [PDF]

, 2020
Interactions between germinal center B cells and immune cells in the microenvironment can play integral roles in transformation and growth of follicular lymphoma (FL).
Ochsenbein, Adrian F., Riether, Carsten
core   +1 more source