Results 61 to 70 of about 1,580,087 (314)

Reshaping the Pancreatic Cancer Microenvironment at Different Stages with Chemotherapy

, 2023
The dynamic tumor microenvironment, especially the immune microenvironment, during the natural progression and/or chemotherapy treatment is a critical frontier in understanding the effects of chemotherapy on pancreatic cancer.
Ying Ying, Zheng Zhang, Maozhen Peng, Wenquan Wang, Liang Liu   +4 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The Influence of the Ketogenic Diet on the Immune Tolerant Microenvironment in Glioblastoma

, 2022
Glioblastoma (GBM) represents an aggressive and immune-resistant cancer. Preclinical investigations have identified anti-tumor activity of a ketogenic diet (KD) potentially being used to target GBM’s glycolytic phenotype.
Chinnaiyan, Prakash, Pravin Kesarwani, Yi Zhao, Prakash Chinnaiyan, Zhao, Yi, Shiva Kant, C. Ryan Miller, Kant, Shiva, Kesarwani, Pravin, Miller, C. Ryan   +9 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

PD-L1/PD-1 Axis in Multiple Myeloma Microenvironment and a Possible Link with CD38-Mediated Immune-Suppression

, 2021
The emerging role of the PD-1/PD-L1 axis in MM immune-microenvironment has been highlighted by several studies. However, discordant data have been reported on PD-1/PD-L1 distribution within the bone marrow (BM) microenvironment of patients with ...
Federica Costa, Paola Storti, Fabio Malavasi, Valentina Marchica, Nicola Giuliani   +4 more
core   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Tumor Immune Microenvironment in Gynecologic Cancers

Cancers, 2023
Gynecologic cancers have varying response rates to immunotherapy due to the heterogeneity of each cancer’s molecular biology and features of the tumor immune microenvironment (TIME). This article reviews key features of the TIME and its role in the pathophysiology and treatment of ovarian, endometrial, cervical, vulvar, and vaginal cancer. Knowledge of
Daniel Margul, Camilla Yu, Mariam M. AlHilli   +2 more
openaire   +2 more sources

Mapping the BCSC-1 interactome in breast cancer

Scientific Reports
BCSC-1 (breast cancer suppressor candidate-1), the official gene symbol VWA5A (von Willebrand factor A domain containing 5 A), is downregulated in a variety of cancer types including breast cancer.
Yuan Ma, Qingchen Zhang, Jiyu Ju, Xiaoyan Fu, Hongbin Du, Pei Zhong, Shengyan Zhang, Zhuowei Li, Yuchen Liu, Lei Gong, Chunling Zhao   +10 more
doaj   +1 more source

CCR2 Enhances Anti-Intracellular Bacterial Infection by Modulating Macrophage Pyroptosis to Rebalance Th Immune Responses

Microorganisms
The treatment of intracellular bacterial infections such as Chlamydia remains a significant clinical challenge due to rising antibiotic resistance and persistent, immunopathology-driven tissue damage.
Shuaini Yang, Jinxi Yu, Jiajia Zeng, Ruoyuan Sun, Yuqing Tuo, Lu Tan, Hong Zhang, Juan Li, Xuchun Che, Hong Bai   +9 more
doaj   +1 more source

Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice

Nature Communications, 2020
The use of tumour exosome-activated dendritic cell (DC) immunotherapy shows promise for the treatment of large established tumours. Here, the authors generate alarmin HMGN1-attached tumour exosomes which significantly improve therapy efficacy by boosting
Bingfeng Zuo, Han Qi, Zhen Lu, Lu Chen, Bo Sun, Rong Yang, Yang Zhang, Zhili Liu, Xianjun Gao, Abin You, Li Wu, Renwei Jing, Qibing Zhou, HaiFang Yin   +13 more
doaj   +1 more source