Results 61 to 70 of about 2,850,822 (303)

Structure of Rad5 provides insights into its role in tolerance to replication stress

Molecular & Cellular Oncology, 2021
The Rad5 family of proteins are critical genome maintenance factors, with helicase-like transcription factor (HLTF) and SNF2 histone linker PHD RING helicase (SHRPH) in humans implicated in several types of cancer.
Miaomiao Shen, Nalini Dhingra, Quan Wang, Xiaoxin Gong, Xin Xu, Hengyao Niu, Xiaolan Zhao, Song Xiang   +7 more
doaj   +1 more source

Simultaneous suppression of PKM2 and PHGDH elicits synergistic anti-cancer effect in NSCLC

Frontiers in Pharmacology, 2023
Metabolic reprogramming is a hallmark of human cancer. Cancer cells exhibit enhanced glycolysis, which allows glycolytic intermediates to be diverted into several other biosynthetic pathways, such as serine synthesis.
Kaixuan Wang, Hao Lu, Xinmiao Wang, Qingxia Liu, Jinxia Hu, Yao Liu, Yao Liu, Meihua Jin, Dexin Kong   +8 more
doaj   +1 more source

The tumour microenvironment links complement system dysregulation and hypoxic signalling. [PDF]

, 2018
The complement system is an innate immune pathway typically thought of as part of the first line of defence against "non-self" species. In the context of cancer, complement has been described to have an active role in facilitating cancer-associated ...
Giaccia, Amato J, Graves, Edward E, Kim, Ryan K, Melemenidis, Stavros, Olcina, Monica M   +4 more
core   +1 more source

Cellular interactions in the tumor microenvironment: the role of secretome [PDF]

, 2019
Over the past years, it has become evident that cancer initiation and progression depends on several components of the tumor microenvironment, including inflammatory and immune cells, fibroblasts, endothelial cells, adipocytes, and extracellular matrix ...
Castelo-Branco, Pedro, da Cunha, Bianca Rodrigues, Domingos, Célia, Henrique, Tiago, Polachini, Giovana Mussi, Stefanini, Ana Carolina Buzzo, Tajara, Eloiza Helena   +6 more
core   +1 more source

Organoid modeling of the tumor immune microenvironment

Cell, 2018
SUMMARY In vitro cancer cultures, including 3-dimensional organoids, typically contain exclusively neoplastic epithelium but require artificial reconstitution to recapitulate the tumor microenvironment (TME).
James T. Neal, Xingnan Li, Junjie Zhu, Valeria Giangarrà, Caitlin L. Grzeskowiak, Ji-hang Ju, Iris H Liu, S. Chiou, A. Salahudeen, A. Smith, B. Deutsch, Lillian Liao, Allison J. Zemek, Fan Zhao, Kasper Karlsson, Liora M. Schultz, Thomas J. Metzner, L. Nadauld, Yuen-Yi Tseng, Sahar Alkhairy, Coyin Oh, P. Keskula, D. Mendoza-Villanueva, Francisco M. De La Vega, P. Kunz, J. Liao, J. Leppert, J. Sunwoo, C. Sabatti, J. Boehm, W. Hahn, Grace X. Y. Zheng, Mark M. Davis, C. Kuo   +33 more
semanticscholar   +1 more source

Static Magnetic Field Accelerates Diabetic Wound Healing by Facilitating Resolution of Inflammation

Journal of Diabetes Research, 2019
Impaired wound healing is commonly encountered in patients with diabetes mellitus, which may lead to severe outcomes such as amputation, if untreated timely. Macrophage plays a critical role in the healing process including the resolution phase. Although
Wenlong Shang, Guilin Chen, Yinxiu Li, Yujuan Zhuo, Yuhong Wang, Zhicai Fang, Ying Yu, Huiwen Ren   +7 more
doaj   +1 more source

CD38 Predicts Favorable Prognosis by Enhancing Immune Infiltration and Antitumor Immunity in the Epithelial Ovarian Cancer Microenvironment

Frontiers in Genetics, 2020
The identification of predictive biomarkers and novel targets to optimize immunotherapy strategies for epithelial ovarian cancer (EOC) is urgently needed. CD38 is a multifunctional glycoprotein that acts as an ectoenzyme and immune receptor. However, the
Ying Zhu, Ying Zhu, Zhigang Zhang, Zhigang Zhang, Zhou Jiang, Yang Liu, Yang Liu, Jianwei Zhou   +7 more
doaj   +1 more source

Immune evasion through mitochondrial transfer in the tumour microenvironment

Nature
Cancer cells in the tumour microenvironment use various mechanisms to evade the immune system, particularly T cell attack1. For example, metabolic reprogramming in the tumour microenvironment and mitochondrial dysfunction in tumour-infiltrating ...
Hideki Ikeda, Katsushige Kawase, Tatsuya Nishi, Tomofumi Watanabe, Keizo Takenaga, T. Inozume, Takamasa Ishino, Sho Aki, Jason Lin, Shusuke Kawashima, Joji Nagasaki, Yuki Ueda, Shinichiro Suzuki, Hideki Makinoshima, M. Itami, Yuki Nakamura, Yasutoshi Tatsumi, Yusuke Suenaga, Takao Morinaga, Akiko Honobe-Tabuchi, Takehiro Ohnuma, T. Kawamura, Y. Umeda, Yasuhiro Nakamura, Y. Kiniwa, E. Ichihara, H. Hayashi, Jun-ichiro Ikeda, T. Hanazawa, Shinichi Toyooka, H. Mano, Takuji Suzuki, Tsuyoshi Osawa, Masahito Kawazu, Yosuke Togashi   +34 more
semanticscholar   +1 more source

Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy

Clinical Cancer Research, 2014
Purpose: Immunomodulatory drugs differ in mechanism-of-action from directly cytotoxic cancer therapies. Identifying factors predicting clinical response could guide patient selection and therapeutic optimization.
J. Taube, A. Klein, J. Brahmer, Haiying Xu, Xiaoyu Pan, J. H. Kim, Lieping Chen, D. Pardoll, S. Topalian, R. Anders   +9 more
semanticscholar   +1 more source

Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment

Immunity, 2022
SUMMARY Primary tumors are drivers of pre-metastatic niche formation, but the coordination by the secondary organ toward metastatic dissemination is underappreciated.
Zheng Gong, Qing Li, Jiayuan Shi, Jian Wei, Peishan Li, Chih-Hao Chang, L. Shultz, G. Ren   +7 more
semanticscholar   +1 more source