Biology of NSCLC: Interplay between Cancer Cells, Radiation and Tumor Immune Microenvironment [PDF]
, 2021 The overall prognosis and survival of non-small cell lung cancer (NSCLC) patients remain poor. The immune system plays an integral role in driving tumor control, tumor progression, and overall survival of NSCLC patients.
Seema Gupta +3 more
core +1 more source
Scientific Reports, 2017 Adiponectin (APN), also known as apM1, Acrp30, GBP28 and adipoQ, is a circulating hormone that is predominantly produced by adipose tissue. Many pharmacological studies have demonstrated that this protein possesses potent anti-diabetic, anti-atherogenic ...
Yinghui Ren +14 more
doaj +1 more source
Structure of Rad5 provides insights into its role in tolerance to replication stress
Molecular & Cellular Oncology, 2021 The Rad5 family of proteins are critical genome maintenance factors, with helicase-like transcription factor (HLTF) and SNF2 histone linker PHD RING helicase (SHRPH) in humans implicated in several types of cancer.
Miaomiao Shen +7 more
doaj +1 more source
The Immune Microenvironment and Cancer Metastasis [PDF]
Cold Spring Harbor Perspectives in Medicine, 2019 The dynamic interplay between neoplastic cells and the immune microenvironment regulates every step of the metastatic process. Immune cells contribute to invasion by secreting a cornucopia of inflammatory factors that promote epithelial-to-mesenchymal transition and remodeling of the stroma.
Asmaa, El-Kenawi +2 more
openaire +2 more sources
Immune Microenvironment Characteristics of Urachal Carcinoma and Its Implications for Prognosis and Immunotherapy [PDF]
, 2022 Urachal carcinoma (UrC) is an exceedingly rare tumor and lacks effective treatment. Herein, we characterized an immune microenvironment characteristic of UrC in detail and identified its implications for prognosis and immunotherapy.
Jierong Chen +6 more
core +1 more source
The Bone Marrow Microenvironment in B-Cell Development and Malignancy [PDF]
, 2022 SIMPLE SUMMARY: B cells are an essential component of the immune system and develop in the bone marrow microenvironment. B-cell development is tightly regulated by the stromal cells, fat cells and bone cells in this microenvironment. However, when B-cell
Anastasia M. Hughes +7 more
core +1 more source
Simultaneous suppression of PKM2 and PHGDH elicits synergistic anti-cancer effect in NSCLC
Frontiers in Pharmacology, 2023 Metabolic reprogramming is a hallmark of human cancer. Cancer cells exhibit enhanced glycolysis, which allows glycolytic intermediates to be diverted into several other biosynthetic pathways, such as serine synthesis.
Kaixuan Wang +8 more
doaj +1 more source
Senescent Stromal Cells in the Tumor Microenvironment: Victims or Accomplices? [PDF]
, 2023 Cellular senescence is a unique cellular state. Senescent cells enter a non-proliferative phase, and the cell cycle is arrested. However, senescence is essentially an active cellular phenotype, with senescent cells affecting themselves and neighboring ...
Minghan Ye +3 more
core +1 more source
Static Magnetic Field Accelerates Diabetic Wound Healing by Facilitating Resolution of Inflammation
Journal of Diabetes Research, 2019 Impaired wound healing is commonly encountered in patients with diabetes mellitus, which may lead to severe outcomes such as amputation, if untreated timely. Macrophage plays a critical role in the healing process including the resolution phase. Although
Wenlong Shang +7 more
doaj +1 more source
Combined Effects of Myeloid Cells in the Neuroblastoma Tumor Microenvironment [PDF]
, 2021 Despite multimodal treatment, survival chances for high-risk neuroblastoma patients remain poor. Immunotherapeutic approaches focusing on the activation and/or modification of host immunity for eliminating tumor cells, such as chimeric antigen receptor ...
Leontari, Ilia +5 more
core +1 more source