Results 1 to 10 of about 15,868,375 (334)
IL-18 binding protein attenuates neuroinflammation and cognitive decline in Alzheimer’s disease [PDF]
Journal of NeuroinflammationNeuroinflammation in Alzheimer’s disease (AD) extends beyond a secondary response to amyloid-β plaques and neurofibrillary tangles, representing a fundamental driver of disease pathogenesis.
Dae Ki Hong +6 more
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Медицинская иммунология, 2014 . Interleukin–18 is one of the main cytokines, inducing production of IFNg. It is the important factor of anti–infectious and anti–tumor immunity. The review represent molecular–genetic and biochemical characteristics of IL–18.
E. V. Yakushenko +2 more
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Expression of IL-18, IL-18 Binding Protein, and IL-18 Receptor by Normal and Cancerous Human Ovarian Tissues: Possible Implication of IL-18 in the Pathogenesis of Ovarian Carcinoma [PDF]
Mediators of Inflammation, 2014 Proinflammatory cytokine IL-18 has been shown to be elevated in the sera of ovarian carcinoma patients. The aim of the study was to examine the levels and cellular origin of IL-18, IL-18 binding protein, and IL-18 receptor in normal and cancerous ovarian
Liat Medina +5 more
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Clinical & Translational Immunology, 2021 Objective In asthma, genome‐wide association studies have shown that interleukin‐18 (IL‐18) receptor 1 gene (IL‐18R1) and sputum IL‐18 are increased during exacerbations. However, the role of the IL‐18 axis in bronchial epithelial function is unclear. To
Davinder Kaur +4 more
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mAbs, 2023 Here, we generated bispecific antibody (bsAb) derivatives that mimic the function of interleukin (IL)-18 based on single domain antibodies (sdAbs) specific to IL-18 Rα and IL-18 Rβ.
Britta Lipinski +16 more
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INFLUENCE OF AN INHIBITOR OF JNK ON THE SECRETION OF THE INFLAMMASOME–DEPENDENT PROINFLAMMATORY CYTOKINES [PDF]
Journal of IMAB, 2020 Purpose: In this study, we determine the influence of prolonged exposure on organic air pollutants, on the secretion of inflammasome-dependent cytokines IL-1β and IL-18.
Boncho Grigorov +3 more
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Pyroptosis in Osteoblasts: A Novel Hypothesis Underlying the Pathogenesis of Osteoporosis
Frontiers in Endocrinology, 2021 Osteoporosis has become a worldwide disease characterized by a reduction in bone mineral density and the alteration of bone architecture leading to an increased risk of fragility fractures.
Zhengbo Tao +10 more
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Research progress of NLRP3 inflammasome in the pathogenesis of psoriasis
Pifu-xingbing zhenliaoxue zazhi, 2022 NLRP3 inflammasome activates IL-1β and IL-18. In recent years, a large number of in vitro and in vivo studies showed elevations in expression levels of NLRP3 inflammasome, IL-1β and IL-18 in psoriasis.
Siman SHI +4 more
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Toxics, 2022 Administration of recombinant human IL-18 binding protein (rhIL-18BP), a natural antagonist of IL-18, significantly increased mouse survival after lethal doses of irradiation. To further understand the roles of IL-18BP in radiation mitigation, we studied
Wanchang Cui +6 more
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Process Mining Organization (PMO) Modeling and Healthcare Processes
Knowledge, 2023 Process mining organizatioQn (PMO) is an innovative approach based on artificial intelligence (AI) decision making suitable for designing healthcare processes for human resource (HR) organizations.
Angelo Rosa, Alessandro Massaro
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