Results 1 to 10 of about 3,545,338 (242)

IL-33 and IL-33-derived DC-based tumor immunotherapy

Experimental and Molecular Medicine
Interleukin-33 (IL-33), a member of the IL-1 family, is a cytokine released in response to tissue damage and is recognized as an alarmin. The multifaceted roles of IL-33 in tumor progression have sparked controversy within the scientific community ...
Myeong-Ho Kang, Yong-Soo Bae
doaj   +4 more sources

IL-33 Potentiates Histaminergic Itch

Journal of Allergy and Clinical Immunology, 2023
Background: Itch is a common symptom that can greatly diminish quality of life. Histamine is a potent endogenous pruritogen, and while antihistamines are often the first-line treatment for itch, in conditions like chronic spontaneous urticaria (CSU ...
A. Trier, A. V. Heul, A. Fredman, V. Le, Zhen Wang, Kelsey L. Auyeung, J. Meixiong, P. Lovato, Michael J. Holtzman, Fang Wang, Xinzhong Dong, Andrew L. Ji, Brian S. Kim   +12 more
semanticscholar   +4 more sources

IL-33 in Rheumatic Diseases [PDF]

Frontiers in Medicine, 2021
Interleukin-33 (IL-33) is a nuclear factor mainly expressed in barrier epithelium, endothelial cells, and fibroblast reticular cells. Some inflammatory cells also express IL-33 under certain conditions.
Yuanji Dong, Jixin Zhong, Lingli Dong
doaj   +3 more sources

IL-33 in Mental Disorders [PDF]

Medicina, 2021
Mental disorders are common in the general population; every year about 25% of the total European population is affected by a mental condition. The prevalence of psychiatric disorders might be underestimated.
Gianluca Pandolfo, Giovanni Genovese, Marco Casciaro, Maria Rosaria Anna Muscatello, Antonio Bruno, Giovanni Pioggia, Sebastiano Gangemi   +6 more
doaj   +4 more sources

Sera Level and Polymorphism of Interleukin-33 Gene in Iraqi Females Patients with Breast Cancer

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2021
Interleukin-33 [IL-33] is a specific ligand for the ST2 receptor, and a member of the IL-1 family. It is a dual-function protein that acts both as an extracellular alarmin cytokine, and an as an intracellular nuclear factor participates in maintaining ...
Asmaa M. Salih Almohaidi, Hazima Mossa Al-Abassi, Zainab Jalil Abdulkareem, Zainab Jalil Abdulkareem   +3 more
doaj   +1 more source

Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer

Cancer Cell, 2022
SUMMARY TH2 and innate lymphoid cells 2 (ILC2) can stimulate tumor growth by secreting pro-tumorigenic cytokines such as IL-4, IL-5 and IL-13. However, the mechanisms by which type 2 immune cells traffic to the tumor microenvironment (TME) are unknown ...
A. Alam, Eric Levanduski, Parker J. Denz, Helena Solleiro Villavicencio, Maulasri Bhatta, Lamees Alhorebi, Yali Zhang, E. C. Gomez, B. Morreale, Sharon Senchanthisai, Jun Li, Steven G. Turowski, S. Sexton, S. Sait, P. Singh, Jianmin Wang, A. Maitra, P. Kalinski, R. DePinho, Huamin Wang, Wenting Liao, S. Abrams, B. Segal, Prasenjit Dey   +23 more
semanticscholar   +1 more source

Interleukin-33 (IL-33): A critical review of its biology and the mechanisms involved in its release as a potent extracellular cytokine.

Cytokine, 2022
Interleukin-33 (IL-33), a member of the IL-1 family, is an alarmin cytokine with crucial roles in tissue homeostasis and repair, type 2 immunity, allergic and non-allergic inflammation, viral infection, and cancer.
C. Cayrol, J. Girard
semanticscholar   +1 more source

Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction

Scientific Reports, 2023
Interleukin (IL)-33 is a broad-acting alarmin cytokine that can drive inflammatory responses following tissue damage or infection and is a promising target for treatment of inflammatory disease.
Elizabeth England, D. G. Rees, I. Scott, Sara Carmen, Denice T. Y. Chan, C. C. Chaillan Huntington, Kirsty F. Houslay, T. Erngren, M. Penney, Jayesh B. Majithiya, L. Rapley, Dorothy A. Sims, C. Hollins, Elizabeth C. Hinchy, Martin D. Strain, B. Kemp, Dominic J. Corkill, Richard May, Katherine A. Vousden, Robin J. Butler, T. Mustelin, T. Vaughan, David C. Lowe, C. Colley, E. S. Cohen   +24 more
semanticscholar   +1 more source

Role of IL-33-ST2 pathway in regulating inflammation: current evidence and future perspectives

Journal of Translational Medicine, 2023
Interleukin (IL)-33 is an alarmin of the IL-1 superfamily localized to the nucleus of expressing cells, such as endothelial cells, epithelial cells, and fibroblasts.
Yilu Zhou, Zhendong Xu, Zhiqiang Liu
semanticscholar   +1 more source

IL-33-induced neutrophilic inflammation and NETosis underlie rhinovirus-triggered exacerbations of asthma.

Mucosal Immunology, 2023
Rhinovirus-induced neutrophil extracellular traps (NETs) contribute to acute asthma exacerbations, however the molecular factors that trigger NETosis in this context remain ill-defined.
Bodie F. Curren, Tufael Ahmed, Daniel R. Howard, Md. Ashik Ullah, Ismail Sebina, R. Rashid, Md. Al Amin Sikder, Patricia Namubiru, Alec Bissell, Sylvia Ngo, D. Jackson, M. Toussaint, M. Edwards, S. Johnston, H. McSorley, S. Phipps   +15 more
semanticscholar   +1 more source