Results 1 to 10 of about 4,627,366 (384)

IL-33 and IL-33-derived DC-based tumor immunotherapy

Experimental and Molecular Medicine
Interleukin-33 (IL-33), a member of the IL-1 family, is a cytokine released in response to tissue damage and is recognized as an alarmin. The multifaceted roles of IL-33 in tumor progression have sparked controversy within the scientific community ...
Myeong-Ho Kang, Yong-Soo Bae
doaj   +4 more sources

IL-33 Potentiates Histaminergic Itch.

Journal of Allergy and Clinical Immunology, 2023
BACKGROUND Itch is a common symptom that can greatly diminish quality of life. Histamine is a potent endogenous pruritogen, and while antihistamines are often the first-line treatment for itch, in conditions like chronic spontaneous urticaria (CSU), many
A. Trier, A. V. Heul, A. Fredman, V. Le, Zhen Wang, Kelsey L. Auyeung, J. Meixiong, P. Lovato, Michael J. Holtzman, Fang Wang, Xinzhong Dong, Andrew L. Ji, Brian S. Kim   +12 more
semanticscholar   +4 more sources

Serum IL-5, POSTN and IL-33 levels in chronic rhinosinusitis with nasal polyposis correlate with clinical severity [PDF]

BMC Immunology, 2022
Background Chronic rhinosinusitis (CRS) is a group of heterogeneous diseases characterized by epithelial inflammation and tissue eosinophilic infiltration.
Hanna Zielińska-Bliźniewska, Milena Paprocka-Zjawiona, Anna Merecz-Sadowska, Radosław Zajdel, Katarzyna Bliźniewska-Kowalska, Katarzyna Malinowska   +5 more
doaj   +2 more sources

Sera Level and Polymorphism of Interleukin-33 Gene in Iraqi Females Patients with Breast Cancer

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2021
Interleukin-33 [IL-33] is a specific ligand for the ST2 receptor, and a member of the IL-1 family. It is a dual-function protein that acts both as an extracellular alarmin cytokine, and an as an intracellular nuclear factor participates in maintaining ...
Asmaa M. Salih Almohaidi, Hazima Mossa Al-Abassi, Zainab Jalil Abdulkareem, Zainab Jalil Abdulkareem   +3 more
doaj   +1 more source

Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer.

Cancer Cell, 2022
TH2 cells and innate lymphoid cells 2 (ILC2) can stimulate tumor growth by secreting pro-tumorigenic cytokines such as interleukin-4 (IL-4), IL-5, and IL-13.
A. Alam, Eric Levanduski, Parker J. Denz, Helena Solleiro Villavicencio, Maulasri Bhatta, Lamees Alhorebi, Yali Zhang, E. C. Gomez, B. Morreale, Sharon Senchanthisai, Jun Li, Steven G. Turowski, S. Sexton, S. Sait, P. Singh, Jianmin Wang, A. Maitra, P. Kalinski, R. DePinho, Huamin Wang, Wenting Liao, S. Abrams, B. Segal, Prasenjit Dey   +23 more
semanticscholar   +1 more source

Role of IL-33-ST2 pathway in regulating inflammation: current evidence and future perspectives

Journal of Translational Medicine, 2023
Interleukin (IL)-33 is an alarmin of the IL-1 superfamily localized to the nucleus of expressing cells, such as endothelial cells, epithelial cells, and fibroblasts.
Yilu Zhou, Zhendong Xu, Zhiqiang Liu
semanticscholar   +1 more source

Tozorakimab (MEDI3506): an anti-IL-33 antibody that inhibits IL-33 signalling via ST2 and RAGE/EGFR to reduce inflammation and epithelial dysfunction

Scientific Reports, 2023
Interleukin (IL)-33 is a broad-acting alarmin cytokine that can drive inflammatory responses following tissue damage or infection and is a promising target for treatment of inflammatory disease.
Elizabeth England, D. G. Rees, I. Scott, Sara Carmen, Denice T. Y. Chan, C. C. Chaillan Huntington, Kirsty F. Houslay, T. Erngren, M. Penney, Jayesh B. Majithiya, L. Rapley, Dorothy A. Sims, C. Hollins, Elizabeth C. Hinchy, Martin D. Strain, B. Kemp, Dominic J. Corkill, Richard May, Katherine A. Vousden, Robin J. Butler, T. Mustelin, T. Vaughan, David C. Lowe, C. Colley, E. S. Cohen   +24 more
semanticscholar   +1 more source

Interleukin-33 (IL-33): A critical review of its biology and the mechanisms involved in its release as a potent extracellular cytokine.

Cytokine, 2022
Interleukin-33 (IL-33), a member of the IL-1 family, is an alarmin cytokine with crucial roles in tissue homeostasis and repair, type 2 immunity, allergic and non-allergic inflammation, viral infection, and cancer.
C. Cayrol, J. Girard
semanticscholar   +1 more source

IL-33-induced neutrophilic inflammation and NETosis underlie rhinovirus-triggered exacerbations of asthma.

Mucosal Immunology, 2023
Rhinovirus-induced neutrophil extracellular traps (NETs) contribute to acute asthma exacerbations, however the molecular factors that trigger NETosis in this context remain ill-defined.
Bodie F. Curren, Tufael Ahmed, Daniel R. Howard, Md. Ashik Ullah, Ismail Sebina, R. Rashid, Md. Al Amin Sikder, Patricia Namubiru, Alec Bissell, Sylvia Ngo, D. Jackson, M. Toussaint, M. Edwards, S. Johnston, H. McSorley, S. Phipps   +15 more
semanticscholar   +1 more source

Macrophages originated IL-33/ST2 inhibits ferroptosis in endometriosis via the ATF3/SLC7A11 axis

Cell Death and Disease, 2023
Endometriosis is a gynecological inflammatory disease that is linked with immune cells, specifically macrophages. IL-33 secreted from macrophages is known to accelerate the progression of endometriosis.
Qiong Wu, Zongwen Liang, Jing Jiang, Xiaoming Feng, Jinming Liu, Zongfeng Zhang, Hongli Wang, Ning Wang, Yanling Gou, Zhi Li, Yingying Cao   +10 more
semanticscholar   +1 more source