Results 1 to 10 of about 72,327,479 (284)

In vitro potency and pharmacokinetics of APG777, a novel anti–IL-13 mAb [PDF]

Journal of Allergy and Clinical Immunology: Global
Background: IL-13 plays a key role in the induction and perpetuation of type 2 immune responses associated with the development of atopic dermatitis and other chronic inflammatory diseases.
Eric Zhu, PhD, Holly Prentice, PhD, Jason Oh, PhD, Hussam Shaheen, PhD, Namita A. Gandhi, PhD, Grant Wickman, PhD, Rebecca Dabora, PhD, Carl L. Dambkowski, MD, Lukas Dillinger, PhD   +8 more
doaj   +2 more sources

Dupilumab attenuate IL-4 and IL-13 synergistic effect on airway remodeling in asthma via blocking IL-4Rα/STAT6 axis [PDF]

Scientific Reports
Airway fibrosis in severe asthma is a hallmark of disease pathology, yet the mechanisms driving fibroblast activation remain incompletely understood. While interleukin-4 (IL-4) and interleukin-13 (IL-13) are central to type 2 inflammation, their combined
Lina Sahnoon, Rola Abujabal, Tasneem M. Alanta, Bushra Mdkhana, Ronald Olivenstein, Ellen Puré, Bassam Mahboub, Yves Laumonnier, Rifat Hamoudi, Khuloud Bajbouj, Qutayba Hamid   +10 more
doaj   +2 more sources

IL-13Rα2 Regulates the IL-13/IFN-γ Balance during Innate Lymphoid Cell and Dendritic Cell Responses to Pox Viral Vector-Based Vaccination

Vaccines, 2021
We have shown that manipulation of IL-13 and STAT6 signaling at the vaccination site can lead to different innate lymphoid cell (ILC)/dendritic cell (DC) recruitment, resulting in high avidity/poly-functional T cells and effective antibody ...
Zheyi Li, Sreeja Roy, Charani Ranasinghe
doaj   +1 more source

Biological Therapy of Severe Asthma with Dupilumab, a Dual Receptor Antagonist of Interleukins 4 and 13

Vaccines, 2022
Interleukin-4 (IL-4) and interleukin-13 (IL-13) are key cytokines involved in the pathophysiology of both immune-inflammatory and structural changes underlying type 2 asthma.
Corrado Pelaia, Giulia Pelaia, Claudia Crimi, Angelantonio Maglio, Giuseppe Armentaro, Cecilia Calabrese, Angela Sciacqua, Luca Gallelli, Alessandro Vatrella   +8 more
doaj   +1 more source

A Case of Papuloerythroderma Successfully Treated with Dupilumab

Case Reports in Dermatology, 2022
Papuloerythroderma is an erythroderma characterized by the composition of dense paving stone shape papules and intertriginous uninvolved skin on the abdominal wall and is often intractable and accompanied by itching.
Ayaka Mizuno, Koji Habe, Yoshiaki Matsushima, Makoto Kondo, Keiichi Yamanaka   +4 more
doaj   +1 more source

Assessment of the rapid effect of dupilumab in two cases of severe asthma comorbid with recurrent eosinophilic chronic rhinosinusitis after endoscopic sinus surgery

Respirology Case Reports, 2021
Dupilumab, a human monoclonal antibody against interleukin‐4 (IL‐4) and IL‐13, has been approved for treating severe asthma and eosinophilic chronic rhinosinusitis (ECRS).
Yoshiro Kai, Masanori Yoshikawa, Masayuki Matsuda, Atsuhiko Fukuoka, Yukio Fujita, Motoo Yamauchi, Shigeo Muro   +6 more
doaj   +1 more source

Changes in novel anti-infalmmatory cytokine concetration in the bood of endurance and race horses at different levels of training

Computational and Structural Biotechnology Journal, 2023
Several anti-inflammatory cytokines have been proposed as markers for exercise monitoring in humans such as the interleukin 1 receptor agonist (IL-ra), or interleukin 13 (IL-13).
Urszula Plisak, Jarosław Szczepaniak, Magdalena Żmigrodzka, Beata Giercuszkiewicz-Hecold, Olga Witkowska-Piłaszewicz   +4 more
doaj   +1 more source

IL-4/IL-13 axis as therapeutic targets in allergic rhinitis and asthma [PDF]

PeerJ, 2022
Allergic rhinitis (AR) is a common disorder of the upper airway, while asthma is a disease affecting the lower airway and both diseases are usually comorbid.
Siti Muhamad Nur Husna, Norasnieda Md Shukri, Noor Suryani Mohd Ashari, Kah Keng Wong   +3 more
doaj   +2 more sources

iIL13Pred: improved prediction of IL-13 inducing peptides using popular machine learning classifiers

BMC Bioinformatics, 2023
Background Inflammatory mediators play havoc in several diseases including the novel Coronavirus disease 2019 (COVID-19) and generally correlate with the severity of the disease.
Pooja Arora, Neha Periwal, Yash Goyal, Vikas Sood, Baljeet Kaur   +4 more
doaj   +1 more source

Impact of Anti-Diabetic Treatments on Circulating Anti-Inflammatory Mediators (IL-10 and IL-13) in Type 2 Diabetes Patients [PDF]

Journal of Bioscience and Applied Research
Background and Objectives: Type 2 diabetes mellitus (T2DM) is a chronic condition marked by persistent hyperglycemia and low-grade inflammation, involving cytokines like IL-10 and IL-13.
Muhannad Shweash, Hatem Hadeed, Mahmood Mukhlif, Mohammed Shwaish, Haitham Abd   +4 more
doaj   +1 more source