Results 1 to 10 of about 2,017,899 (336)
IL-4 Is a Key Requirement for IL-4- and IL-4/IL-13-Expressing CD4 Th2 Subsets in Lung and Skin
Frontiers in Immunology, 2018 Although IL-4 is long associated with CD4 Th2 immune responses, its role in Th2 subset development in non-lymphoid tissues is less clear. We sought to better define IL-4’s role in CD4 Th2 responses by using transgenic mice that express a dual IL-4 AmCyan/
Melanie Sarah Prout +3 more
doaj +3 more sources
Interleukins 4 and 13 in Asthma: Key Pathophysiologic Cytokines and Druggable Molecular Targets
Frontiers in Pharmacology, 2022 Interleukins (IL)-4 and -13 play a pivotal role in the pathobiology of type-2 asthma. Indeed, IL-4 is crucially involved in Th2 cell differentiation, immunoglobulin (Ig) class switching and eosinophil trafficking.
Corrado Pelaia +8 more
doaj +1 more source
Associations between Interleukin-4 and COVID-19 severity: A systematic review and meta-analysis [PDF]
Journal of Health and Social Sciences, 2022 Introduction: This systematic review and meta-analysis aimed to determine the correlation between IL-4 concentrations and COVID-19 severity. Methods: This study was designed as a systematic review and meta-analysis and was performed in accordance to ...
Michal MATUSZEWSKI +10 more
doaj +1 more source
Marking IL-4-producing cells by knock-in of the IL-4 gene [PDF]
International Immunology, 1999 IL-4 is a cytokine which can be expressed by a number of cell types including Th2 cells, mast cells and a population of CD4+ NK1.1+ NK T cells. Although phenotypic markers exist for identifying each of these cell types, there is at present no known cell surface marker common to all IL-4-producing cells.
I C, Ho +4 more
openaire +2 more sources
IL-4 Exacerbates Anaphylaxis [PDF]
The Journal of Immunology, 2003 Abstract We evaluated whether IL-4, a cytokine critical for inducing allergic responses, also contributes to the effector phase of allergy. Pretreatment of mice with IL-4 or the related cytokine, IL-13, rapidly and dramatically increased the severity of anaphylaxis induced by cross-linking FcεRI or FcγRIII.
Richard T, Strait +4 more
openaire +2 more sources
CLINICAL AND IMMUNOLOGICAL EFFECTIVENESS OF TREATMENT OF RAGWEED POLLINOSIS IN THE SAMARA REGION
Медицинская иммунология, 2021 Allergic rhinitis and bronchial asthma are widespread respiratory allergic diseases. In some territories of the Russian Federation, the dominant cause of pollinosis is ragweed.
N. N. Zhukova +3 more
doaj +1 more source
IL-4 and its polymorphism (IL4-589C/T) in cervical neoplasia
Медицинская иммунология, 2023 The transition of cervical neoplasia (CIN) to cervical cancer occurs with the active participation of IL-4, for which both pro- and antitumor effects have been shown with tumors of various localizations.
T. V. Abakumova +5 more
doaj +1 more source
Experimental Parasitology, 1996 This review focuses on the role of IL-4 in the immune response which develops during infection with the trematode parasite Schistosoma mansoni. The emphasis is on our own recent studies in the mouse model.
E J, Pearce +3 more
openaire +2 more sources
Enhancement of human IL-4 activity by soluble IL-4 receptorsin vitro [PDF]
European Journal of Immunology, 1999 The recombinant form of the extracellular domain of the IL-4 receptor (sIL-4R) is a potential candidate to neutralize IL-4; however, murine sIL-4R displayed both antagonistic and agonistic activity in vivo. Here we show that human recombinant sIL-4R induced the formation of complexed IL-4 in supernatants of activated T cells in a dose-dependent manner ...
T, Jung +3 more
openaire +2 more sources
The role of IL-4 in psoriasis [PDF]
Expert Review of Clinical Immunology, 2017 Psoriasis is a chronic inflammatory disease of skin and joints affecting approximately 1–2% of the population worldwide.
Matthias, Hahn, Kamran, Ghoreschi
openaire +2 more sources