Results 1 to 10 of about 96,694,076 (289)

IL-4 Is a Key Requirement for IL-4- and IL-4/IL-13-Expressing CD4 Th2 Subsets in Lung and Skin

Frontiers in Immunology, 2018
Although IL-4 is long associated with CD4 Th2 immune responses, its role in Th2 subset development in non-lymphoid tissues is less clear. We sought to better define IL-4’s role in CD4 Th2 responses by using transgenic mice that express a dual IL-4 AmCyan/
Melanie Sarah Prout, Ryan L. Kyle, Franca Ronchese, Graham Le Gros   +3 more
doaj   +3 more sources

Evaluation of The Correlation and Reproducibility between Histamine, IL-4, and IL-13 Release from Human Basophils

Iranian Journal of Allergy, Asthma and Immunology, 2014
Human  basophils play a key role in allergic diseases such as asthma and in a variety of  immunological disorders.  The  generation  of  IL-4  and  IL-13  can  be  induced  from basophil  by  IgE-mediated   and   non-IgE-mediated   mechanisms.
Nahid Eskandari, Reza Bastan, Maryam Ahmadi, Peter T Peachell   +3 more
doaj  

The expression levels of IL-4 and IL-13 in the serum and blister fluid of patients with bullous pemphigoid

Pifu-xingbing zhenliaoxue zazhi
Objective To investigate the expression levels of type 2 inflammatory cytokines, IL-4 and IL-13, in the serum and blister fluid of patients with bullous pemphigoid (BP).
Yao ZHOU, Lijun TENG, Guomin LI, Jie XU, Jinjin ZHENG, Hao FANG, Ruzeng XUE   +6 more
doaj   +1 more source

Single-Chain Soluble Receptor Fusion Proteins as Versatile Cytokine Inhibitors

Frontiers in Immunology, 2020
Cytokines are small secreted proteins that among many functions also play key roles in the orchestration of inflammation in host defense and disease.
Aurora Holgado, Aurora Holgado, Harald Braun, Harald Braun, Kenneth Verstraete, Kenneth Verstraete, Domien Vanneste, Domien Vanneste, Nico Callewaert, Nico Callewaert, Savvas N. Savvides, Savvas N. Savvides, Inna S. Afonina, Inna S. Afonina, Rudi Beyaert, Rudi Beyaert   +15 more
doaj   +1 more source

Assessment of the rapid effect of dupilumab in two cases of severe asthma comorbid with recurrent eosinophilic chronic rhinosinusitis after endoscopic sinus surgery

Respirology Case Reports, 2021
Dupilumab, a human monoclonal antibody against interleukin‐4 (IL‐4) and IL‐13, has been approved for treating severe asthma and eosinophilic chronic rhinosinusitis (ECRS).
Yoshiro Kai, Masanori Yoshikawa, Masayuki Matsuda, Atsuhiko Fukuoka, Yukio Fujita, Motoo Yamauchi, Shigeo Muro   +6 more
doaj   +1 more source

The level of IL-12, IL-10, IL-4, and MMP-13 in cutaneous leishmaniasis patients

Medical Journal of Babylon
Background: Cutaneous leishmaniasis (CL) is a dermatological condition that arises due to the presence of protozoan parasites. The disease disproportionately impacts those residing in economically disadvantaged regions and is closely linked to factors ...
Abrar Kareem Dhari, Ali Mohammed Abed, Suha Maher Abed   +2 more
doaj   +1 more source

Immunomodulatory effect of hepatitis B virus (HBV) antigens and MRSA antigens on immune response

Medical Journal of Babylon
Background: Methicillin-resistant Staphylococcus aureus is one of the most common human invaders and causes different types of illness worldwide.
Entidhar A. Hadi, Mohammad Abd-Kadhum Al-Saadi, Kaiser N. Madlum   +2 more
doaj   +1 more source

Increase in serum IL-4 in response to venetoclax therapy in xenograft models of acute myeloid leukaemia

Медицинская иммунология
Despite significant progress in basic and preclinical research into acute myeloid leukaemia (AML), the five-year survival rate for patients with AML remains poor, highlighting the urgent need for new combination therapies. Over the past decade, increased
D. A. Bogdanova, V. V. Shindyapin, E. D. Kolosova, T. V. Pukhalskaya, N. A. Budkina, A. A. Shatilova, O. N. Demidov   +6 more
doaj   +1 more source

Metformin Protects Against Radiation-Induced Heart Injury and Attenuates the Up-regulation of Dual Oxidase Genes Following Rat’s Chest Irradiation [PDF]

International Journal of Molecular and Cellular Medicine, 2018
Radiation-induced heart toxicity is one of the serious side effects after  a radiation disaster or radiotherapy for patients with chest cancers, leading to a reduction in the quality of life of the patients.
Rasoul Yahyapour, Peyman Amini, Hana Saffar, Saeed Rezapoor, Elahe Motevaseli, Mohsen Cheki, Bagher Farhood, Farzad Nouruzi, Dheyauldeen Shabeeb, Ahmed Eleojo Musa, Masoud Najafi   +10 more
doaj  

PROMOTOR POLYMORPHISM OF IL-4, IL-6, AND IL-10 GENES AMONG PATIENTS WITH BREAST CANCER

Медицинская иммунология, 2014
In spite of extreme controversies on possible role of cytokines as regulating factors in cancer pathology, their role during carcinogenesis is beyond doubts.
A. V. Shevchenko, O. V. Golovanova, M. Ju. Kolomejtchuk, V. I. Konenkov, E. Ju. Garbukov, M. N. Stakheeva   +5 more
doaj   +1 more source