Results 31 to 40 of about 1,845,267 (245)
Current Opinion in Immunology, 1999 IL-4 plays an important role in regulating immune responses. Distinct signaling pathways, including those for gene activation and cell differentiation and those for cell proliferation and protection from apoptosis, are initiated from the receptor complex for IL-4 following ligand-receptor engagement. Several advances have been made in our understanding
P Y, Pan, P, Rothman
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Differential Effects of Alarmins on Human and Mouse Basophils
Frontiers in Immunology, 2022 Epithelial-derived alarmins (IL-33, TSLP, and IL-25) play an upstream role in the pathogenesis of asthma. Basophil-derived cytokines are a pivotal component of allergic inflammation.
Adriana R. Gambardella +17 more
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IL-4 in the Brain: A Cytokine To Remember [PDF]
The Journal of Immunology, 2012 Abstract IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions of the normal brain, such as memory and learning. In this review, we summarize current knowledge of the basic immunology of IL-4, describe how and where this ...
Sachin P, Gadani +3 more
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The Possible Roles of IL-4/IL-13 in the Development of Eosinophil-Predominant Severe Asthma
BiomoleculesBronchial asthma is characterized by airway inflammation, airway hyperresponsiveness, and reversible airway obstruction. Eosinophils contribute to the pathogenesis of airway disease mainly by releasing eosinophil-specific granules, lipid mediators ...
Kazuyuki Nakagome, Makoto Nagata
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Virulence, 2019 Citrobacter rodentium infection is a murine model for pathogenic intestinal Escherichia coli infection. C. rodentium infection causes an initial decrease in mucus layer thickness, followed by an increase during clearance.
S. Sharba +12 more
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Association of IL-4 with pachychoroid neovasculopathy
Scientific Reports, 2022 Abstract The purpose of this study was to identify inflammatory cytokines that are associated with pachychoroid neovasculopathy (PNV). Seventy-five eyes of 75 patients with PNV, 145 eyes of 145 patients with neovascular age-related macular degeneration without pachyvessels, and 150 eyes of 150 normal subjects were examined for the levels of ...
Takashi Baba +10 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen +23 more
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Медицинская иммунология, 2018 Our aim was to study the influence of IL4-589C>T gene polymorphism on IL-4 expression in patients, living in Zabaikalsky Region with a diagnosis of chronic traumatic osteomyelitis developing after fractures of long bones of extremities.The study ...
A. M. Miromanov +2 more
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Children with sickle cell disease (SCD) face multiple acute and chronic medical complications that may impact their quality of life as reported by patients themselves. Health‐related social needs (HRSNs), such as food and housing insecurity, are common in people with SCD, but the association between HRSNs and patient‐reported ...
Sarah J. Marks +5 more
wiley +1 more source
Monaldi Archives for Chest DiseaseAsthma is a heterogeneous disease characterized by chronic airway inflammation. It is defined by the history of respiratory symptoms such as wheeze, shortness of breath, chest tightness, and cough that vary over time and intensity, together with ...
Nidhi Girdhar +5 more
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