Crosstalk between ILC2s and Th2 cells varies among mouse models [PDF]
Cell Reports, 2023 Summary: Type 2 T helper (Th2) cells and group 2 innate lymphoid cells (ILC2s) provide protection against helminth infection and are involved in allergic responses. However, their relative importance and crosstalk during type 2 immune responses are still
Rama K. Gurram +14 more
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Conventional and pathogenic Th2 cells in inflammation, tissue repair, and fibrosis [PDF]
Frontiers in Immunology, 2022 Type 2 helper T (Th2) cells, a subset of CD4+ T cells, play an important role in the host defense against pathogens and allergens by producing Th2 cytokines, such as interleukin-4 (IL-4), IL-5, and IL-13, to trigger inflammatory responses.
Kota Kokubo +7 more
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SERPINB10 contributes to asthma by inhibiting the apoptosis of allergenic Th2 cells [PDF]
Respiratory Research, 2021 Background Serine peptidase inhibitor, clade B, member 10 (SERPINB10) contributes to allergic inflammation in asthma. However, its role in the T-helper type 2 (Th2) response of allergic asthma is not known.
Yuqing Mo +8 more
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Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling. [PDF]
PLoS ONE, 2021 Histamine, which is mainly produced by mast cells and basophils, participates in various allergic symptoms, and some studies have reported that macrophages also produce histamine.
Naruhito Iwasaki +6 more
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Differentiation and Regulation of Bovine Th2 Cells In Vitro [PDF]
CellsBovine Th2 cells have usually been characterized by IL4 mRNA expression, but it is unclear whether their IL4 protein expression corresponds to transcription.
Anmol Kandel +4 more
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The Metabolic Requirements of Th2 Cell Differentiation [PDF]
Frontiers in Immunology, 2019 Upon activation, naïve CD4+ T cells differentiate into a number of specialized T helper (Th) cell subsets. Th2 cells are central players in immunity to helminths and are implicated in mediating the inflammatory pathology associated with allergies.
Julian M. Stark +2 more
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Pathogenic Effector Th2 Cells in Allergic Eosinophilic Inflammatory Disease
Frontiers in Medicine, 2017 There is an absolute requirement for Th2 cells in the pathogenesis of allergen-driven eosinophil-rich type 2 inflammation. Although Th2 cells are generally regarded as a homogeneous population, in the past decade there has been increasing evidence for a ...
Alyssa Mitson-Salazar, Calman Prussin
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Frontiers in Immunology, 2018 Antigen-primed T cells respond to restimulation much faster than naïve T cells and form the cellular basis of immunological memory. The formation of memory Th2 cells starts when naïve CD4 T cells are transformed into effector Th2 cells and is completed ...
Atsushi Onodera +3 more
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New Insights into HIV Life Cycle, Th1/Th2 Shift during HIV Infection and Preferential Virus Infection of Th2 Cells: Implications of Early HIV Treatment Initiation and Care [PDF]
LifeThe theory of immune regulation involves a homeostatic balance between T-helper 1 (Th1) and T-helper 2 (Th2) responses. The Th1 and Th2 theories were introduced in 1986 as a result of studies in mice, whereby T-helper cell subsets were found to direct ...
Joseph Hokello +6 more
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Bach2: A Key Regulator in Th2-Related Immune Cells and Th2 Immune Response
Journal of Immunology Research, 2022 Th2 immune response is essential for providing protection against pathogens and orchestrating humoral immunity. However, excessive Th2 immune response leads to the pathogenesis of Th2 inflammation diseases, including asthma, allergic rhinitis, and atopic
Guo Liu, Feng Liu
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