Results 41 to 50 of about 267,317 (298)

NKG2A inhibits TH2 cell effector function in vitro

BMC Pulmonary Medicine, 2007
Background We previously reported that NKG2A, a key inhibitory ligand for HLA-E, is expressed on activated TH2 but not TH1 cells. Here we measured cytokine expression in human ex vivo TH2 cells upon activation with anti-CD3/28 and challenge with an NKG2A-
Mojgani Bahar, Freishtat Robert J, Nazemzadeh Maryam, Nagaraju Kanneboyina, Hoffman Eric P   +4 more
doaj   +1 more source

Bach2: A Key Regulator in Th2-Related Immune Cells and Th2 Immune Response

Journal of Immunology Research, 2022
Th2 immune response is essential for providing protection against pathogens and orchestrating humoral immunity. However, excessive Th2 immune response leads to the pathogenesis of Th2 inflammation diseases, including asthma, allergic rhinitis, and atopic
Guo Liu, Feng Liu
doaj   +1 more source

Type 2 Innate Lymphoid Cells in Allergic Disease. [PDF]

, 2013
Type II innate lymphoid cells (ILC2) are a novel population of lineage-negative cells that produce high levels of Th2 cytokines IL-5 and IL-13. ILC2 are found in human respiratory and gastrointestinal tissue as well as in skin.
Doherty, Taylor A, Lund, Sean, Walford, Hannah H   +2 more
core   +2 more sources

The Primary Responses of Murine Neonatal Lymph Node CD4+ Cells are Th2-skewed and are Sufficient for the Development of Th2-biased Memory

Clinical and Developmental Immunology, 2003
Exposure of neonatal mice to antigen often results in Th2-biased responses in later life. Examples of this Th2 tendency are (a) secondary antibody responses dominated by the Th2-associated IgG1 isotype and (b) Th2-mediated tolerance to alloantigens.
Becky Adkins, Yurong Bu, Vladimir Vincek, Patricia Guevara   +3 more
doaj   +1 more source

Allergen-specific Th2 cells as targets for immune intervention in allergic disease

Allergology International, 1996
Allergen-specific Th2 cells from atopic individuals generally belong to the T helper 2 (Th2) subset producing, among other cytokines, high levels of IL-4, IL-5 and IL-13, but low levels of IL-2 and IFN-γ following activation.
Jan E. de Vries
doaj   +1 more source

Critical Involvement of CD44 in T Helper Type 2 Cell-Mediated Eosinophilic Airway Inflammation in a Mouse Model of Acute Asthma

Frontiers in Immunology, 2022
Interactions between CD44 and hyaluronan (HA) are crucial for recruiting leukocytes to inflamed tissues. This review summarizes findings from our studies of the roles of CD44-HA interactions in leukocyte trafficking, with a particular focus on airway T ...
Shigeki Katoh
doaj   +1 more source

A transcriptome-driven analysis of epithelial brushings and bronchial biopsies to define asthma phenotypes in U-BIOPRED [PDF]

, 2016
RATIONALE AND OBJECTIVES: Asthma is a heterogeneous disease driven by diverse immunologic and inflammatory mechanisms. We used transcriptomic profiling of airway tissues to help define asthma phenotypes. METHODS: The transcriptome from bronchial biopsies
Adcock, IM, Auffray, C, Baribaud, F, Chanez, P, Chung, KF, Corfield, J, Dahlen, B, Dahlen, SE, De Meulder, B, Djukanovic, R, Fleming, L, Fowler, S, Guo, Y, Hoda, U, Howarth, P, Krug, N, Kuo, CS, Lefaudeux, D, Loza, M, Pandis, I, Pavlidis, S, Rossios, C, Rowe, A, Sandström, T, Shaw, D, Sousa, A, Sterk, PJ, U-BIOPRED Project Team, Wilson, SJ   +28 more
core   +4 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Kinetics and cellular site of glycolipid loading control [PDF]

, 2009
CD1d-restricted natural killer T cells (NKT cells) possess a wide range of effector and regulatory activities that are related to their ability to secrete both T helper 1 (Th1) cell- and Th2 cell-type cytokines.
Arora, Pooja, Baena, Andres, Baine, Ian, Bricard, Gabriel, Goldberg, Michael F., Im, Jin S., Jerud, Elliot S., Molano, Alberto, Ndonye, Rachel M., Venkataswamy, Manjunatha M., Yu, Karl O.A.   +10 more
core  

Mucosal immune responses following intestinal nematode infection. [PDF]

, 2014
In most natural environments, the large majority of mammals harbour parasitic helminths that often live as adults within the intestine for prolonged periods (1-2 years).
Else KJ, Garcia FT, McSharry C, Nakajima H, Oku Y, Pawlowski Z, Petit‐Frere C, Robinson K, Tilney LG, Urban JF, WHO, WHO   +11 more
core   +4 more sources