Results 21 to 30 of about 4,912,109 (290)

Metabolic Interdependency of Th2 Cell-Mediated Type 2 Immunity and the Tumor Microenvironment

Frontiers in Immunology, 2021
The function of T cells is critically dependent on their ability to generate metabolic building blocks to fulfil energy demands for proliferation and consecutive differentiation into various T helper (Th) cells.
Simon Schreiber, Christoph M. Hammers, Achim J. Kaasch, Achim J. Kaasch, Burkhart Schraven, Burkhart Schraven, Anne Dudeck, Anne Dudeck, Sascha Kahlfuss, Sascha Kahlfuss, Sascha Kahlfuss   +10 more
doaj   +1 more source

Phenotypic Analysis of Nasal CD69 CD4 Tissue-Resident Memory T Cells in Eosinophilic Chronic Rhinosinusitis With Nasal Polyps [PDF]

Journal of Rhinology
Background and Objectives Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disease, classified into eosinophilic and non-eosinophilic subtypes. Although CD4+ tissue-resident memory T (TRM) cells play diverse roles in tissue homeostasis, their
Min-Seok Rha, Gyeongyeob Kim, Sol Lee
doaj   +1 more source

Suppression of allergic airway inflammation by helminth-induced regulatory T cells [PDF]

, 2005
Allergic diseases mediated by T helper type (Th) 2 cell immune responses are rising dramatically in most developed countries. Exaggerated Th2 cell reactivity could result, for example, from diminished exposure to Th1 cell–inducing microbial infections ...
Lamb, Jonathan, Mark S. Wilson, Adam Balic, Constance A.M. Finney, Taylor, Matthew D, Finney, Constance A, Matthew D. Taylor, Rick M. Maizels, Maizels, Rick, Jonathan R. Lamb, Wilson, Mark A, Balic, Adam   +11 more
core   +1 more source

Epicutaneous immunization with type II collagen inhibits both onset and progression of chronic collagen-induced arthritis. [PDF]

, 2007
Epicutaneous immunization is a potential non-invasive technique for antigen-specific immune-modulation. Topical application of protein antigens to barrier-disrupted skin induces potent antigen-specific immunity with a strong Th2-bias.
Strobel, S, Strid, J, Callard, R, Marco Londei, Londei, M, Lee Aun Tan, Stephan Strobel, Robin Callard, Jessica Strid, Tan, LA   +9 more
core   +2 more sources

Chitinase and Fizz family members are a generalized feature of nematode infection with selective Upregulation of Ym1 and F10.1 by antigen-presenting cells [PDF]

, 2005
Ym1 and Fizz1 are secreted proteins that have been identified in a variety of Th2-mediated inflammatory settings. We originally found Ym1 and Fizz1 as highly expressed macrophage genes in a Brugia malayi infection model.
Coulson, P.S., Allen, J.E., Wilson, R.A., Gallagher, Iain J, Patricia S. Coulson, Judith E. Allen, Wilson, R A, P'ng Loke, Maizels, Rick M, Loke, P., Loke, P'ng, Taylor, M.D., Allen, Judith E, Nair, Meera G, Meera G. Nair, Nair, M.G., Taylor, Matthew D, Maizels, R.M., Matthew D. Taylor, Gallagher, L.J., Rick M. Maizels, Coulson, Patricia S, Iain J. Gallagher, R. A. Wilson   +23 more
core   +1 more source

Dupilumab Effects on Innate Lymphoid Cell and Helper T Cell Populations in Patients with Atopic Dermatitis

JID Innovations, 2021
Group 2 innate lymphoid cells (ILCs) are thought to contribute to the pathogenesis of atopic dermatitis (AD). IL-4 stimulates T helper type 2 (Th2) cells and ILC2s to proliferate and produce cytokines. Dupilumab, an antibody against the IL-4 receptor, is
Yasutomo Imai, Minori Kusakabe, Makoto Nagai, Koubun Yasuda, Kiyofumi Yamanishi   +4 more
doaj   +1 more source

Regulation of Th2 Cell Immunity by Dendritic Cells [PDF]

Immune Network, 2016
Th2 cell immunity is required for host defense against helminths, but it is detrimental in allergic diseases in humans. Unlike Th1 cell and Th17 cell subsets, the mechanism by which dendritic cells modulate Th2 cell responses has been obscure, in part because of the inability of dendritic cells to provide IL-4, which is indispensable for Th2 cell ...
Na, Hyeongjin, Cho, Minkyoung, Chung, Yeonseok   +2 more
openaire   +2 more sources

Human CD4+ Memory T Cells Can Become CD4+IL-9+ T Cells [PDF]

, 2010
Background: IL-9 is a growth factor for T- and mast-cells that is secreted by human Th2 cells. We recently reported that IL-4+TGF-β directs mouse CD4+CD25−CD62L+ T cells to commit to inflammatory IL-9 producing CD4+ T cells.
Popoola, Joyce, Wenda Gao, Terry B Strom, Gao Wenda, Strom, Terry B., Strom Terry B., Strom, TB, Putheti, P, Popoola, J, Awasthi, A, Amit Awasthi, Awasthi Amit, Prabhakar Putheti, Popoola Joyce, Awasthi, Amit, Putheti Prabhakar, Joyce Popoola, Gao, W   +17 more
core   +2 more sources

Menin Controls the Memory Th2 Cell Function by Maintaining the Epigenetic Integrity of Th2 Cells [PDF]

The Journal of Immunology, 2017
Abstract Posttranslational modifications of histones are well-established epigenetic modifications that play an important role in gene expression and regulation. These modifications are partly mediated by the Trithorax group (TrxG) complex, which regulates the induction or maintenance of gene transcription.
Atsushi Onodera, Masahiro Kiuchi, Kota Kokubo, Miki Kato, Tomohiro Ogino, Shu Horiuchi, Urara Kanai, Kiyoshi Hirahara, Toshinori Nakayama   +8 more
openaire   +2 more sources

The helminth product, ES-62, protects against airway inflammation by resetting the Th cell phenotype [PDF]

, 2013
We previously demonstrated inhibition of ovalbumin (OVA)-induced allergic airway hyper-responsiveness in the mouse using ES-62, a phosphorylcholine-containing glycoprotein secreted by the filarial nematode, Acanthocheilonema viteae.
Al-Riyami, Lamyaa, Kean, Dorothy, McSharry, Charles, Rzepecka, Justyna, Siebeke, Ivonne, Harnett, Margaret, Coltherd, Jennifer, Steiger, Christina, Harnett, William   +8 more
core   +4 more sources