Results 21 to 30 of about 160,112 (257)

Alarming dendritic cells for Th2 induction [PDF]

The Journal of Experimental Medicine, 2008
There is an ever-increasing understanding of the mechanisms by which pathogens such as bacteria, viruses, and protozoa activate dendritic cells (DCs) to drive T helper type 1 (Th1) responses, but we know much less about how these cells elicit Th2 responses.
MacDonald, Andrew S.; id_orcid 0000-0002-5356-1149, Maizels, Rick M.   +1 more
openaire   +5 more sources

Mercury: god of Th2 cells? [PDF]

Clinical and Experimental Immunology, 1995
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openaire   +2 more sources

Helminth-induced Th2 cell dysfunction is distinct from exhaustion and is maintained in the absence of antigen.

PLoS Neglected Tropical Diseases, 2019
T cell-intrinsic regulation, such as anergy, adaptive tolerance and exhaustion, is central to immune regulation. In contrast to Type 1 and Type 17 settings, knowledge of the intrinsic fate and function of Th2 cells in chronic Type 2 immune responses is ...
Johanna A Knipper, Alasdair Ivens, Matthew D Taylor   +2 more
doaj   +1 more source

Inducible costimulator expression regulates the magnitude of Th2-mediated airway inflammation by regulating the number of Th2 cells. [PDF]

PLoS ONE, 2009
Inducible Costimulator (ICOS) is an important regulator of Th2 lymphocyte function and a potential immunotherapeutic target for allergy and asthma. A SNP in the ICOS 5' promoter in humans is associated with increased atopy and serum IgE in a founder ...
Bryan S Clay, Rebecca A Shilling, Hozefa S Bandukwala, Tamson V Moore, Judy L Cannon, Andrew A Welcher, Joel V Weinstock, Anne I Sperling   +7 more
doaj   +1 more source

CD11a polymorphisms regulate TH2 cell homing and TH2-related disease [PDF]

Journal of Allergy and Clinical Immunology, 2014
TH2-dependent diseases vary in severity according to genotype, but relevant gene polymorphisms remain largely unknown. The integrin CD11a is a critical determinant of allergic responses, and allelic variants of this gene might influence allergic phenotypes.We sought to determine major CD11a allelic variants in mice and human subjects and their ...
Knight, John, Lee, Seung-Hyo, Roberts, Luz, Smith, C. Wayne, Weiss, Scott, Kheradmand, Farrah, Corry, David B.   +6 more
openaire   +4 more sources

Beyond CCR7: dendritic cell migration in type 2 inflammation

Frontiers in Immunology
Conventional dendritic cells (cDCs) are crucial antigen-presenting cells that initiate and regulate T cell responses, thereby shaping immunity against pathogens, innocuous antigens, tumors, and self-antigens. The migration of cDCs from peripheral tissues
Audrey Meloun, Audrey Meloun, Beatriz León   +2 more
doaj   +1 more source

Thymic Stromal Lymphopoietin and Cancer: Th2-Dependent and -Independent Mechanisms

Frontiers in Immunology, 2020
The thymic stromal lymphopoietin (TSLP) is an IL-7-like cytokine originally cloned from a murine thymic stromal cell line, and subsequently a human homolog was identified using database search methods.
Maria Pia Protti, Maria Pia Protti, Lucia De Monte, Lucia De Monte   +3 more
doaj   +1 more source

Impact of Enhancer of Zeste Homolog 2 on T Helper Cell-Mediated Allergic Rhinitis

Frontiers in Immunology, 2017
Enhancer of zeste homolog 2 (Ezh2) has been shown to play a role in the differentiation of T helper (Th) 1 and 2 cells in mice studies using Ezh2-deficient T cells.
Tsung-Yun Hou, Tsung-Yun Hou, Tsung-Yun Hou, Ming-Rong Chen, Yu-Ching Chou, Po-Chieh Kan, Yi-Ta Tsai, Yi-Ta Tsai, Tai-Lung Cha, Tai-Lung Cha, Tai-Lung Cha   +10 more
doaj   +1 more source

NKG2A inhibits TH2 cell effector function in vitro

BMC Pulmonary Medicine, 2007
Background We previously reported that NKG2A, a key inhibitory ligand for HLA-E, is expressed on activated TH2 but not TH1 cells. Here we measured cytokine expression in human ex vivo TH2 cells upon activation with anti-CD3/28 and challenge with an NKG2A-
Mojgani Bahar, Freishtat Robert J, Nazemzadeh Maryam, Nagaraju Kanneboyina, Hoffman Eric P   +4 more
doaj   +1 more source

The Primary Responses of Murine Neonatal Lymph Node CD4+ Cells are Th2-skewed and are Sufficient for the Development of Th2-biased Memory

Clinical and Developmental Immunology, 2003
Exposure of neonatal mice to antigen often results in Th2-biased responses in later life. Examples of this Th2 tendency are (a) secondary antibody responses dominated by the Th2-associated IgG1 isotype and (b) Th2-mediated tolerance to alloantigens.
Becky Adkins, Yurong Bu, Vladimir Vincek, Patricia Guevara   +3 more
doaj   +1 more source