Results 21 to 30 of about 4,589,213 (294)
Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses [PDF]
, 2008 Alum is used as a vaccine adjuvant and induces T<sub>h</sub>2 responses and T<sub>h</sub>2-driven antibody isotype production against co-injected antigens.
White, Janice +11 more
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Epicutaneous immunization with type II collagen inhibits both onset and progression of chronic collagen-induced arthritis. [PDF]
, 2007 Epicutaneous immunization is a potential non-invasive technique for antigen-specific immune-modulation. Topical application of protein antigens to barrier-disrupted skin induces potent antigen-specific immunity with a strong Th2-bias.
Strobel, S +9 more
core +2 more sources
Regulation of Th2 Cell Immunity by Dendritic Cells [PDF]
Immune Network, 2016 Th2 cell immunity is required for host defense against helminths, but it is detrimental in allergic diseases in humans. Unlike Th1 cell and Th17 cell subsets, the mechanism by which dendritic cells modulate Th2 cell responses has been obscure, in part because of the inability of dendritic cells to provide IL-4, which is indispensable for Th2 cell ...
Na, Hyeongjin +2 more
openaire +2 more sources
Human CD4+ Memory T Cells Can Become CD4+IL-9+ T Cells [PDF]
, 2010 Background: IL-9 is a growth factor for T- and mast-cells that is secreted by human Th2 cells. We recently reported that IL-4+TGF-β directs mouse CD4+CD25−CD62L+ T cells to commit to inflammatory IL-9 producing CD4+ T cells.
Popoola, Joyce +17 more
core +2 more sources
JID Innovations, 2021 Group 2 innate lymphoid cells (ILCs) are thought to contribute to the pathogenesis of atopic dermatitis (AD). IL-4 stimulates T helper type 2 (Th2) cells and ILC2s to proliferate and produce cytokines. Dupilumab, an antibody against the IL-4 receptor, is
Yasutomo Imai +4 more
doaj +1 more source
Menin Controls the Memory Th2 Cell Function by Maintaining the Epigenetic Integrity of Th2 Cells [PDF]
The Journal of Immunology, 2017 Abstract Posttranslational modifications of histones are well-established epigenetic modifications that play an important role in gene expression and regulation. These modifications are partly mediated by the Trithorax group (TrxG) complex, which regulates the induction or maintenance of gene transcription.
Atsushi Onodera +8 more
openaire +2 more sources
Frontiers in Immunology, 2018 Antigen-primed T cells respond to restimulation much faster than naïve T cells and form the cellular basis of immunological memory. The formation of memory Th2 cells starts when naïve CD4 T cells are transformed into effector Th2 cells and is completed ...
Atsushi Onodera +3 more
doaj +1 more source
Alarming dendritic cells for Th2 induction [PDF]
The Journal of Experimental Medicine, 2008 There is an ever-increasing understanding of the mechanisms by which pathogens such as bacteria, viruses, and protozoa activate dendritic cells (DCs) to drive T helper type 1 (Th1) responses, but we know much less about how these cells elicit Th2 responses.
MacDonald, Andrew S.; id_orcid 0000-0002-5356-1149 +1 more
openaire +5 more sources
A differential interplay between the expression of Th1/Th2/Treg related cytokine genes in Teladorsagia circumcincta infected DRB1*1101 carrier lambs [PDF]
, 2011 peer-reviewedSubstantial debate exists on whether the immune response between sheep resistant and susceptible to gastrointestinal nematodes can be differentiated into a Th1 and Th2 phenotype.
Barbara Good +15 more
core +1 more source
Mercury: god of Th2 cells? [PDF]
Clinical and Experimental Immunology, 1995 link_to_subscribed_fulltext
openaire +2 more sources