Interferon-γ secreted by recruited Th1 cells in peritoneal cavity inhibits the formation of malignant ascites [PDF]
Cell Death Discovery, 2023 Type 1 T helper (Th1) cells generate an efficient antitumor immune response in multiple malignancies. The functions of Th1 cells in malignant ascites (MA) have not been elucidated.
Chang Liu +7 more
doaj +2 more sources
The emerging role of Th1 cells in atherosclerosis and its implications for therapy [PDF]
Frontiers in Immunology, 2023 Atherosclerosis is a chronic progressive inflammatory disease of the large and medium-sized artery walls. The molecular mechanisms regulating the onset and progression of atherosclerosis remain unclear.
Jiaojiao Chen +7 more
doaj +2 more sources
A molecular signature for IL-10–producing Th1 cells in protozoan parasitic diseases [PDF]
JCI Insight, 2023 Control of visceral leishmaniasis (VL) depends on proinflammatory Th1 cells that activate infected tissue macrophages to kill resident intracellular parasites.
Chelsea L. Edwards +17 more
doaj +2 more sources
Id3 expression identifies CD4<sup>+</sup> memory Th1 cells. [PDF]
Proc Natl Acad Sci U S A, 2022 Memory CD4 + T cells play a pivotal role in mediating long-term protective immunity, positioning them as an important target in vaccine development. However, multiple functionally distinct helper CD4 + T-cell subsets can arise in response to a single invading pathogen, complicating the ...
Shaw LA +5 more
europepmc +3 more sources
Enhanced Rg3 negatively regulates Th1 cell responses
Journal of Ginseng Research, 2019 Background: Korean Red Ginseng (KRG; Panax ginseng Meyer) is a widely used medicinal herb known to exert various immune modulatory functions. KRG and one of its purified components, ginsenoside Rg3, are known to possess anti-inflammatory activities.
Minkyoung Cho +3 more
doaj +3 more sources
An in silico approach for modelling T-helper polarizing iNKT cell agonists [PDF]
, 2014 Many analogues of the glycolipid alpha-galactosylceramide (α-GalCer) are known to activate iNKT cells through their interaction with CD1d-expressing antigen-presenting cells, inducing the release of Th1 and Th2 cytokines. Because of iNKT cell involvement
ASPESLAGH, SANDRINE +9 more
core +11 more sources
Frontiers in Immunology, 2022 T helper 1 cells (Th1 cells) and T helper 17 cells (Th17 cells) play pivotal roles in the pathogenesis of various autoimmune diseases, including psoriasis and inflammatory bowel disease (IBD).
Jiyoon Park +7 more
doaj +1 more source
Stable T-bet(+)GATA-3(+) Th1/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation. [PDF]
PLoS Biology, 2013 Differentiated T helper (Th) cell lineages are thought to emerge from alternative cell fate decisions. However, recent studies indicated that differentiated Th cells can adopt mixed phenotypes during secondary immunological challenges.
Michael Peine +9 more
doaj +1 more source
Annals of the New York Academy of Sciences, 2010 Autoreactive effector CD4+ T cells have been associated with the pathogenesis of autoimmune disorders. Early studies implicated the interferon (IFN)‐γ‐producing T helper (Th)1 subset of CD4+ cells as the causal agents in the pathogenesis of autoimmunity. However, further studies have suggested a more complex story. In models thought to be driven by Th1
Jesse M, Damsker +2 more
openaire +2 more sources
Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease [PDF]
, 2009 Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2 cytokines are modulators of ulcerative colitis. This concept has been challenged by the description of tolerising regulatory T cells (Treg) and by proinflammatory ...
Brand, Stephan
core +1 more source