Results 1 to 10 of about 198,196 (300)
A molecular signature for IL-10–producing Th1 cells in protozoan parasitic diseases [PDF]
JCI Insight, 2023 Control of visceral leishmaniasis (VL) depends on proinflammatory Th1 cells that activate infected tissue macrophages to kill resident intracellular parasites.
Chelsea L. Edwards +17 more
doaj +3 more sources
Interferon-γ secreted by recruited Th1 cells in peritoneal cavity inhibits the formation of malignant ascites [PDF]
Cell Death Discovery, 2023 Type 1 T helper (Th1) cells generate an efficient antitumor immune response in multiple malignancies. The functions of Th1 cells in malignant ascites (MA) have not been elucidated.
Chang Liu +7 more
doaj +2 more sources
Cell Reports, 2017 Recent data indicate that the differentiation state of Th1 cells determines their protective capacity against tuberculosis. Therefore, we examined the role of Th1-polarizing factors in the generation of protective and non-protective subsets of Mtb ...
Michelle A. Sallin +5 more
doaj +3 more sources
Regulatory T cells converted from Th1 cells in tumors suppress cancer immunity via CD39 [PDF]
Journal of Experimental MedicineSangnee Tan, Jing Hao, Jing Ge
exaly +2 more sources
Annals of the New York Academy of Sciences, 2010 Autoreactive effector CD4+ T cells have been associated with the pathogenesis of autoimmune disorders. Early studies implicated the interferon (IFN)‐γ‐producing T helper (Th)1 subset of CD4+ cells as the causal agents in the pathogenesis of autoimmunity. However, further studies have suggested a more complex story. In models thought to be driven by Th1
Jesse M, Damsker +2 more
openaire +2 more sources
Frontiers in Immunology, 2022 T helper 1 cells (Th1 cells) and T helper 17 cells (Th17 cells) play pivotal roles in the pathogenesis of various autoimmune diseases, including psoriasis and inflammatory bowel disease (IBD).
Jiyoon Park +7 more
doaj +1 more source
Stable T-bet(+)GATA-3(+) Th1/Th2 hybrid cells arise in vivo, can develop directly from naive precursors, and limit immunopathologic inflammation. [PDF]
PLoS Biology, 2013 Differentiated T helper (Th) cell lineages are thought to emerge from alternative cell fate decisions. However, recent studies indicated that differentiated Th cells can adopt mixed phenotypes during secondary immunological challenges.
Michael Peine +9 more
doaj +1 more source
Imbalances in T Cell-Related Transcription Factors Among Patients with Hashimoto’s Thyroiditis
Sultan Qaboos University Medical Journal, 2017 Objectives: Imbalances in effector T cell functioning have been associated with a number of autoimmune diseases, including Hashimoto’s thyroiditis (HT).
Vahid Safdari +3 more
doaj +1 more source
Autoimmunity, 2017 Multiple sclerosis (MS) is a highly detrimental autoimmune disease of the central nervous system. There is no cure for it but the treatment typically focuses on subsiding severity and recurrence of the disease.
Weshely Kujur +6 more
doaj +1 more source
Transcription factors gene expression in chronic rhinosinusitis with and without nasal polyps
Radiology and Oncology, 2019 Chronic rhinosinusitis (CRS) current therapeutic approaches still fail in some patients with severe persistent symptoms and recurrences after surgery.
Soklic Tanja Kosak +6 more
doaj +1 more source