Results 31 to 40 of about 198,196 (300)

Reactivation of TH1 cells in peripheral tissues

, 2023
CD4+ T cells play, as a key player of the adaptive immune system, a critical role in orchestrating an effective immune response during infections, autoimmunity or cancer.
Kiljan, Martha
core  

Essential Role for CD30-Transglutaminase 2 Axis in Memory Th1 and Th17 Cell Generation

Frontiers in Immunology, 2020
Memory helper T (Th) cells are crucial for secondary immune responses against infectious microorganisms but also drive the pathogenesis of chronic inflammatory diseases.
Akane S. Suzuki, Ryoji Yagi, Motoko Y. Kimura, Chiaki Iwamura, Kenta Shinoda, Atsushi Onodera, Atsushi Onodera, Kiyoshi Hirahara, Damon J. Tumes, Damon J. Tumes, Ryo Koyama-Nasu, Siiri E. Iismaa, Robert M. Graham, Shinichiro Motohashi, Toshinori Nakayama   +14 more
doaj   +1 more source

Imbalance of helper T cell type 1, helper T cell type 2 and associated cytokines in patients with systemic lupus erythematosus: A meta-analysis

Frontiers in Pharmacology, 2022
Objective: Th1 and Th2 cells and their associated cytokines function in the pathogenesis of systemic lupus erythematosus (SLE), but their exact roles are uncertain.
Shate Xiang, Jingjing Zhang, Mengge Zhang, Suhai Qian, Rongyun Wang, Yao Wang, Yingshi Xiang, Xinghong Ding   +7 more
doaj   +1 more source

Persistence of effector memory Th1 cells is regulated by Hopx.

, 2010
Th1 cells are prominent in inflamed tissue, survive conventional immunosuppression, and are believed to play a pivotal role in driving chronic inflammation.
Albrecht, I;Niesner, U;Janke, M;Menning, A;Loddenkemper, C;Kuhl, AA;Lepenies, I;Lexberg, MH;Westendorf, K;Hradilkova, K;Grün, J;Hamann, A;Epstein, JA;Chang, HD;Tokoyoda, K;Radbruch, A
core   +1 more source

CXCR3 LIGANDS CONTRIBUTE TO Th1-INDUCED INFLAMMATION BUT NOT TO HOMING OF Th1 CELLS INTO THE LUNG [PDF]

Experimental Lung Research, 2008
Th1 cells are implicated in numerous pulmonary inflammatory disorders, and adoptive transfer of alloreactive Th1 cells mediates lung injury and inflammation in mice. In response to Th1-mediated immune injury, CXCR3 ligands IP10 and MIG are markedly induced. Because Th1 cells express high levels of CXCR3, their recruitment and activity may be influenced
Anne M, Manicone, Kristi M, Burkhart, Bao, Lu, Joan G, Clark   +3 more
openaire   +2 more sources

CXCR3-Expressing T Cells in Infections and Autoimmunity

Frontiers in Bioscience-Landmark
The chemokine receptor CXCR3 and its ligands (MIG/CXCL9, IP-10/CXCL10, and I-TAC/CXCL11) play a central role in the generation of cellular inflammation, both in the protective responses to invading pathogens, and in different pathological conditions ...
Artem Rubinstein, Igor Kudryavtsev, Natalia Arsentieva, Zoia R. Korobova, Dmitry Isakov, Areg A. Totolian   +5 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Functional characteristics of Th1, Th17, and ex-Th17 cells in EAE revealed by intravital two-photon microscopy

Journal of Neuroinflammation, 2020
Background T helper (Th) 17 cells are a highly plastic subset of T cells, which in the context of neuroinflammation, are able to acquire pathogenic features originally attributed to Th1 cells (resulting in so called ex-Th17 cells).
Julia Loos, Samantha Schmaul, Theresa Marie Noll, Magdalena Paterka, Miriam Schillner, Julian T. Löffel, Frauke Zipp, Stefan Bittner   +7 more
doaj   +1 more source

Enhanced Rg3 negatively regulates Th1 cell responses

Journal of Ginseng Research, 2019
Background: Korean Red Ginseng (KRG; Panax ginseng Meyer) is a widely used medicinal herb known to exert various immune modulatory functions. KRG and one of its purified components, ginsenoside Rg3, are known to possess anti-inflammatory activities.
Minkyoung Cho, Garam Choi, Inbo Shim, Yeonseok Chung   +3 more
doaj   +1 more source

Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17 [PDF]

Journal of Leukocyte Biology, 2007
AbstractRecent evidence fromseveral groups indicates that IL-17-producing Th17 cells, rather than, as once was thought, IFN-γ-producing Th1 cells, can represent the key effector cells in the induction/development of several autoimmune and allergic disorders.
Susumu, Nakae, Yoichiro, Iwakura, Hajime, Suto, Stephen J, Galli   +3 more
openaire   +2 more sources