Results 31 to 40 of about 4,626,188 (194)

Functional and pathogenic differences of Th1 and Th17 cells in experimental autoimmune encephalomyelitis.

PLoS ONE, 2010
BackgroundThere is consensus that experimental autoimmune encephalomyelitis (EAE) can be mediated by myelin specific T cells of Th1 as well as of Th17 phenotype, but the contribution of either subset to the pathogenic process has remained controversial ...
Helena S Domingues, Marsilius Mues, Hans Lassmann, Hartmut Wekerle, Gurumoorthy Krishnamoorthy   +4 more
doaj   +1 more source

CXCL10+ peripheral activation niches couple preferred sites of Th1 entry with optimal APC encounter

Cell Reports, 2021
Summary: Correct positioning of T cells within infected tissues is critical for T cell activation and pathogen control. Upon tissue entry, effector T cells must efficiently locate antigen-presenting cells (APC) for peripheral activation.
Hen Prizant, Nilesh Patil, Seble Negatu, Noor Bala, Alexander McGurk, Scott A. Leddon, Angela Hughson, Tristan D. McRae, Yu-Rong Gao, Alexandra M. Livingstone, Joanna R. Groom, Andrew D. Luster, Deborah J. Fowell   +12 more
doaj   +1 more source

Th1 polarization defines the synovial fluid T cell compartment in oligoarticular juvenile idiopathic arthritis

JCI Insight, 2021
Oligoarticular juvenile idiopathic arthritis (oligo JIA) is the most common form of chronic inflammatory arthritis in children, yet the cause of this disease remains unknown. To understand immune responses in oligo JIA, we immunophenotyped synovial fluid
Amélie M. Julé, Kacie J. Hoyt, Kevin Wei, Maria Gutierrez-Arcelus, Maria L. Taylor, Julie Ng, James A. Lederer, Siobhan M. Case, Margaret H. Chang, Ezra M. Cohen, Fatma Dedeoglu, Melissa M. Hazen, Jonathan S. Hausmann, Olha Halyabar, Erin Janssen, Jeffrey Lo, Mindy S. Lo, Esra Meidan, Jordan E. Roberts, Mary Beth F. Son, Robert P. Sundel, Pui Y. Lee, Talal Chatila, Peter A. Nigrovic, Lauren A. Henderson   +24 more
doaj   +1 more source

Fludarabine Ameliorates Lupus Nephritis by Inhibiting T Cell Infiltration through STAT1 in R848-induced Mice Models

Korean Journal of Clinical Laboratory Science
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease caused by both genetic and environmental factors. Fludarabine is a selective inhibitor of signal transducer and activator of transcription 1 (STAT1). Recently, STAT1 inhibitors have been
Se Gwang JANG
doaj   +1 more source

Increased IFN-γ-producing Th17/Th1 cells and their association with lung function and current smoking status in patients with chronic obstructive pulmonary disease

BMC Pulmonary Medicine, 2019
Background Th17 cells are believed to be important proinflammatory cells in the pathogenesis of chronic obstructive pulmonary disease (COPD). Recent evidence demonstrates that Th17 cells display substantial developmental plasticity, giving rise to Th17 ...
Weihan Xu, Ruimin Li, Yongchang Sun
doaj   +1 more source

Essential Role for CD30-Transglutaminase 2 Axis in Memory Th1 and Th17 Cell Generation

Frontiers in Immunology, 2020
Memory helper T (Th) cells are crucial for secondary immune responses against infectious microorganisms but also drive the pathogenesis of chronic inflammatory diseases.
Akane S. Suzuki, Ryoji Yagi, Motoko Y. Kimura, Chiaki Iwamura, Kenta Shinoda, Atsushi Onodera, Atsushi Onodera, Kiyoshi Hirahara, Damon J. Tumes, Damon J. Tumes, Ryo Koyama-Nasu, Siiri E. Iismaa, Robert M. Graham, Shinichiro Motohashi, Toshinori Nakayama   +14 more
doaj   +1 more source

B Cells Regulate Neutrophilia during Mycobacterium tuberculosis Infection and BCG Vaccination by Modulating the Interleukin-17 Response [PDF]

, 2013
We have previously demonstrated that B cells can shape the immune response to Mycobacterium tuberculosis, including the level of neutrophil infiltration and granulomatous inflammation at the site of infection. The present study examined the mechanisms by
Porcelli, SA, Wang, Yanhua, Steven A. Porcelli, William R Jacobs, Flynn, Joanne L, Chen, Y, John Chan, Kozakiewicz, Lee, Qinglin Ou, Lee Kozakiewicz, Chan, John, Xu, J, Ou, Qinglin, Yong Chen (109188), John Chan (47914), Jacobs, WR, Flynn, JL, Ou, Q, Jacobs, William R, William R. Jacobs, Dunussi-Joannopoulos, K, Dunussi-Joannopoulos, Kyri, Steven A. Porcelli (47915), Chen, Yong, Joanne L Flynn, Xu, Jiayong, Kozakiewicz, L, Jiayong Xu (432778), Wang, Y, Joanne L. Flynn (5655565), William R. Jacobs Jr (199645), Chan, J, Lee Kozakiewicz (432777), Qinglin Ou (432779), Joanne L. Flynn, Yanhua Wang, Porcelli, Steven A, Yanhua Wang (127897), Jiayong Xu, Steven A Porcelli, Yong Chen, Kyri Dunussi-Joannopoulos, Kyri Dunussi-Joannopoulos (344714)   +42 more
core   +2 more sources

Imbalance of helper T cell type 1, helper T cell type 2 and associated cytokines in patients with systemic lupus erythematosus: A meta-analysis

Frontiers in Pharmacology, 2022
Objective: Th1 and Th2 cells and their associated cytokines function in the pathogenesis of systemic lupus erythematosus (SLE), but their exact roles are uncertain.
Shate Xiang, Jingjing Zhang, Mengge Zhang, Suhai Qian, Rongyun Wang, Yao Wang, Yingshi Xiang, Xinghong Ding   +7 more
doaj   +1 more source

Human CD4+ Memory T Cells Can Become CD4+IL-9+ T Cells [PDF]

, 2010
Background: IL-9 is a growth factor for T- and mast-cells that is secreted by human Th2 cells. We recently reported that IL-4+TGF-β directs mouse CD4+CD25−CD62L+ T cells to commit to inflammatory IL-9 producing CD4+ T cells.
Popoola, Joyce, Wenda Gao, Terry B Strom, Gao Wenda, Strom, Terry B., Strom Terry B., Strom, TB, Putheti, P, Popoola, J, Awasthi, A, Amit Awasthi, Awasthi Amit, Prabhakar Putheti, Popoola Joyce, Awasthi, Amit, Putheti Prabhakar, Joyce Popoola, Gao, W   +17 more
core   +2 more sources

CXCR3-Expressing T Cells in Infections and Autoimmunity

Frontiers in Bioscience-Landmark
The chemokine receptor CXCR3 and its ligands (MIG/CXCL9, IP-10/CXCL10, and I-TAC/CXCL11) play a central role in the generation of cellular inflammation, both in the protective responses to invading pathogens, and in different pathological conditions ...
Artem Rubinstein, Igor Kudryavtsev, Natalia Arsentieva, Zoia R. Korobova, Dmitry Isakov, Areg A. Totolian   +5 more
doaj   +1 more source