Results 51 to 60 of about 198,196 (300)

Gardiquimod Nanoemulsion Targets Cutaneous Leishmaniasis Lesions Reducing Systemic Toxicity and Parasite Burden

Advanced Healthcare Materials, EarlyView.
Nanoemulsion delivery of a TLR7 agonist enhances safety and promotes colocalization with Leishmania‐infected macrophages in skin lesions, enabling a ∼2‐log reduction in parasite burden. However, tissue‐level constraints and TLR‐driven regulatory feedback generate a mixed immune response that limits complete parasite clearance.
Carmen Palomino‐Cano, M. Carmen Mera‐Delgado, Esther Moreno, Esther Larrea, Lecnia Aguirre, Jonathan Miguel Zanatta, Sónia Barros‐Carvalho, Iola F. Duarte, Ricardo Silvestre, Juan M. Irache, Javier Carrión, Socorro Espuelas   +11 more
wiley   +1 more source

Pathologic Th1–Treg Cells Exacerbate Acute Lung Injury and Lethality in Sepsis

Cells
Sepsis is characterized by dysregulated immune responses induced by damage-associated molecular patterns, such as extracellular cold-inducible RNA-binding protein (eCIRP), that frequently lead to acute lung injury (ALI) and high mortality.
Takuya Murao, Atsushi Murao, Monowar Aziz, Ping Wang   +3 more
doaj   +1 more source

Overcoming CD4 Th1 Cell Fate Restrictions to Sustain Antiviral CD8 T Cells and Control Persistent Virus Infection

Cell Reports, 2016
Viral persistence specifically inhibits CD4 Th1 responses and promotes Tfh immunity, but the mechanisms that suppress Th1 cells and the disease consequences of their loss are unclear. Here, we demonstrate that the loss of CD4 Th1 cells specifically leads
Laura M. Snell, Ivan Osokine, Douglas H. Yamada, Justin Rafael De la Fuente, Heidi J. Elsaesser, David G. Brooks   +5 more
doaj   +1 more source

Rapid Fabrication of Self‐Propelled and Steerable Magnetic Microcatheters for Precision Medicine

Advanced Materials, EarlyView.
A rapid Joule heating fabrication method for the production of self‐propelling, adaptive microcatheters, with tunable stiffness and integrated microfluidic channels is presented. Demonstrated through three microrobotic designs, including a steerable guiding catheter, an untethered wave‐crawling TubeBot, and a distal‐end propelled microcatheter, it was ...
Zhi Chen, Boris Rivkin, David Castellanos‐Robles, Ivan Soldatov, Lukas Beyer, Mariana Medina‐Sánchez   +5 more
wiley   +1 more source

A Hybrid Computational Framework for PCF‐based SPR Sensor With Machine Learning and xAI

Advanced Materials Interfaces, EarlyView.
A photonic crystal fiber‐based surface plasmon resonance (SPR) sensor integrating rectangular air holes along with conventional circular air holes achieves exceptional wavelength sensitivity of 15,000 nm/RIU across a broad refractive index range of 1.31–1.39. Integrated machine learning with explainable AI (xAI) models achieves high prediction accuracy
Mahabur Rahman Fahim, Sudeep Paul, Musrat Jahan, Md Abu Shahid Chowdhury   +3 more
wiley   +1 more source

Increased plasticity of non-classic Th1 cells toward the Th17 phenotype

, 2019
Objectives: To analyze occurrence and plasticity of two recently described distinct subtypes of Th1 cells named classic (CD161−/CCR6−) and non-classic (CD161+/CCR6+) Th1 cells in early rheumatoid arthritis (RA) patients and healthy controls (HCs ...
Hendrik Schulze-Koops (26044), Antonia Klose (7513799), Jan Leipe (7513793), Fausto Pirronello (7513796), Alla Skapenko (54650)   +4 more
core   +1 more source

An Imaging‐Guided, Patient‐Specific Guiding Aid (RWNGuide) for Safe and Reproducible Inner Ear Drug Delivery

Advanced Materials Technologies, EarlyView.
A patient‐specific, imaging‐guided aid enables precise and reproducible drug delivery to the inner ear. By guiding therapeutic agents directly to the round window niche, this approach reduces variability in drug localization, improves delivery safety, and addresses a critical bottleneck in inner ear therapy, offering a scalable strategy for precision ...
Yanjing Luo, Shanshan Jiang, Yimian Luo, Adele Moatti, Farnaz Matin‐Mann   +4 more
wiley   +1 more source

Results of Th17 and Th1 cells.

, 2016
(A) The percentage of circulating Th17 cells was significantly lower in lymphoma patients than normal controls (P = 0.0328). (B) Circulating Th17 cells were decreased significantly in patients with B-NHL (P = 0.0122) compared with NC while there was no ...
Ting Lu (149031), Shuang Yu (181261), Congcong Yin (848718), Yan Liu (25061), Daoxin Ma (212170), Zhi Liu (165121), Chunyan Ji (443711), Jingjing Ye (84458)   +7 more
core   +1 more source

Combining network modeling and gene expression microarray analysis to explore the dynamics of Th1 and Th2 cell regulation. [PDF]

PLoS Computational Biology, 2010
Two T helper (Th) cell subsets, namely Th1 and Th2 cells, play an important role in inflammatory diseases. The two subsets are thought to counter-regulate each other, and alterations in their balance result in different diseases.
Marco Pedicini, Fredrik Barrenäs, Trevor Clancy, Filippo Castiglione, Eivind Hovig, Kartiek Kanduri, Daniele Santoni, Mikael Benson   +7 more
doaj   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source