Results 51 to 60 of about 4,626,188 (194)
Pathologic Th1–Treg Cells Exacerbate Acute Lung Injury and Lethality in Sepsis
CellsSepsis is characterized by dysregulated immune responses induced by damage-associated molecular patterns, such as extracellular cold-inducible RNA-binding protein (eCIRP), that frequently lead to acute lung injury (ALI) and high mortality.
Takuya Murao +3 more
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Cell Reports, 2016 Viral persistence specifically inhibits CD4 Th1 responses and promotes Tfh immunity, but the mechanisms that suppress Th1 cells and the disease consequences of their loss are unclear. Here, we demonstrate that the loss of CD4 Th1 cells specifically leads
Laura M. Snell +5 more
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Combining network modeling and gene expression microarray analysis to explore the dynamics of Th1 and Th2 cell regulation. [PDF]
PLoS Computational Biology, 2010 Two T helper (Th) cell subsets, namely Th1 and Th2 cells, play an important role in inflammatory diseases. The two subsets are thought to counter-regulate each other, and alterations in their balance result in different diseases.
Marco Pedicini +7 more
doaj +1 more source
CXCR3 LIGANDS CONTRIBUTE TO Th1-INDUCED INFLAMMATION BUT NOT TO HOMING OF Th1 CELLS INTO THE LUNG [PDF]
Experimental Lung Research, 2008 Th1 cells are implicated in numerous pulmonary inflammatory disorders, and adoptive transfer of alloreactive Th1 cells mediates lung injury and inflammation in mice. In response to Th1-mediated immune injury, CXCR3 ligands IP10 and MIG are markedly induced. Because Th1 cells express high levels of CXCR3, their recruitment and activity may be influenced
Anne M, Manicone +3 more
openaire +2 more sources
Integrative Cancer TherapiesBackground: Radiation-induced quantitative deficiency of T helper 1 (Th1) cells accelerates lung tumor development. Here, we evaluated IL-7R–STAT5 signaling in Th1 recovery after irradiation and examined how catalpol contributes to Th1 reconstitution by ...
Shan Zhang MM +5 more
doaj +1 more source
Requirements for development of T helper 1 and T follicular helper cells from a common precursor
Cell ReportsSummary: T helper (Th) and T follicular helper (Tfh) cells support cellular and humoral immunity, respectively. How activated CD4+ T cells commit to these fates remains unclear.
Douwe M.T. Bosma +9 more
doaj +1 more source
CD28-Dependent CTLA-4 Expression Fine-Tunes the Activation of Human Th17 Cells
iScience, 2020 Summary: Previous work has demonstrated that Th17 memory cells but not Th1 cells are resistant to CD28/CTLA-4 blockade with CTLA-4 Ig, leading us to investigate the individual roles of the CD28 and CTLA-4 cosignaling pathways on Th1 versus Th17 cells. We
Scott M. Krummey +3 more
doaj +1 more source
Cellular immunity of naïve and BCG vaccinated neonates [PDF]
, 2010 Includes abstract.Includes bibliographical references (leaves 153-187).Despite more than 95% vaccination coverage with Mycobacterium bovis Bacille Calmette-Guérin (BCG), tuberculosis (TB) remains epidemic in South Africa.
Watkins, Marcia Linda Vivienne
core +1 more source
Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17 [PDF]
Journal of Leukocyte Biology, 2007 AbstractRecent evidence fromseveral groups indicates that IL-17-producing Th17 cells, rather than, as once was thought, IFN-γ-producing Th1 cells, can represent the key effector cells in the induction/development of several autoimmune and allergic disorders.
Susumu, Nakae +3 more
openaire +2 more sources
Prevention of arthritis by interleukin 10-producing B cells [PDF]
, 2003 In this study we have shown that activation of arthritogenic splenocytes with antigen and agonistic anti-CD40 gives raise to a B cell population that produce high levels of interleukin (IL)-10 and low levels of interferon (IFN)-{gamma}. Transfer of these
Mauri, C. +7 more
core +1 more source