Results 61 to 70 of about 320,868 (298)

On‐Surface Indigo‐Based Bimolecular Coordination Networks with Programmable Regular or Vitreous Structure

Advanced Functional Materials, EarlyView.
A previously unreported coordination motif stabilising single Fe atoms by indigo chelation and pyridyl coordination on Au(111) has been revealed. By using planar tritopic pyridyl linkers (TPyB), extended 2D porous networks of indigo3(TPyB)2Fe6 form. These networks can be crystalline or vitreous and offer an environment where individual coordination ...
Hongxiang Xu, Ritam Chakraborty, Biao Yang, Dennis Meier, Joachim Reichert, Svetlana Klyatskaya, Mario Ruben, Shobhana Narasimhan, Johannes V. Barth, Anthoula C. Papageorgiou   +9 more
wiley   +1 more source

Modelling and investigation of the CD4⁺ T cells-macrophages paradox in melanoma immunotherapies [PDF]

, 2017
It is generally accepted that tumour cells can be eliminated by M1 anti-tumour macrophages and CD8+ T cells. However, experimental results over the past 10-15 years have shown that B16 mouse melanoma cells can be eliminated by the CD4+ T cells alone ...
Allavena, Almatroodi, Asquith, Barros, Benzekry, Bergmann, Boer, Borghans, Brown, Burkholder, Chen, Coussens, Danciu, De Monte, de Pillis, den Breems, DeNardo, Eftimie, Eftimie, Ehrich, Fishman, Flach, Friberg, Gauthier, Gliozzi, Gross, Hanahan, Haneen Hamam, Helming, Heusinkveld, Hsieh, Hung, Jenkins, Kim, Knutson, Kobayashi, Kogan, Laird, Lamagna, Laydon, Lee, Louzoun, Louzoun, Lucey, Magombedze, Mantovani, Martinez, Mattes, Mills, Moore, Murphy, Panzer, Preuße, Protti, Raluca Eftimie, Roberts, Romagnani, Sarapata, Sica, Solinas, Talkington, Tatsumi, Taylor-Robinson, Voena, Wang, Wang, Wang, Wigginton, Wodarz, Wong, Xie, Yamaguchi, Yates, Zhang, Zhu   +74 more
core   +1 more source

Th1 and Th17 Cells Induce Proliferative Glomerulonephritis [PDF]

Journal of the American Society of Nephrology, 2009
Th1 effector CD4+ cells contribute to the pathogenesis of proliferative and crescentic glomerulonephritis, but whether effector Th17 cells also contribute is unknown. We compared the involvement of Th1 and Th17 cells in a mouse model of antigen-specific glomerulonephritis in which effector CD4+ cells are the only components of adaptive immunity that ...
Shaun A, Summers, Oliver M, Steinmetz, Ming, Li, Joshua Y, Kausman, Timothy, Semple, Kristy L, Edgtton, Dorin-Bogdan, Borza, Hal, Braley, Stephen R, Holdsworth, A Richard, Kitching   +9 more
openaire   +2 more sources

Biomimetic Nanovaccine Integrating Dendritic Cell Exosomes with Tumor Cell Membranes for Sustained Prophylaxis Against Glioblastoma

Advanced Functional Materials, EarlyView.
We have developed DEX/GM, an all‐natural, personalizable hybrid vaccine designed by coating dendritic cell‐derived exosomes (DEX) onto tumor cell membranes (GM) for sustained prophylaxis against glioblastoma (GBM). ABSTRACT Glioblastoma (GBM), one of the most aggressive and lethal brain tumors, remains incurable with a poor clinical prognosis.
Shanshan Li, Dongya Zhang, Shiyu Wang, Changhe Pang, Meng Zheng, Bingyang Shi, Yan Zou   +6 more
wiley   +1 more source

Signaling via interleukin-4, receptor alpha chain is required for successful vaccination against schistosomiasis in BALB/c mice [PDF]

, 2001
Radiation-attenuated (RA) schistosome larvae are potent stimulators of innate immune responses at the skin site of exposure (pinna) that are likely to be important factors in the development of Th1-mediated protective immunity.
Anderson S., Anderson S., Anderson S., Artis D., Bancroft A. J., Bancroft A. J., Barner M., Belkaid Y., Brewer J. M., Brombacher F., Coulson P. S., D'Andrea A., de Andres B., Dean D. A., Delgado V., Donaldson D. D., Faquim-Mauro E. L., Galbiati F., Grunig G., Guler M. L., Hilton D. J., Hoffmann K. F., Hsieh C. S., James S. L., Jankovic D., Jankovic D., Jankovic D., King C. L., King C. L., Kopf M., Magram J., Mangold B. L., Matthews D. J., Mattner F., McKenzie G. J., Metwali A., Mohrs M., Mohrs M., Mountford A. P., Mountford A. P., Mountford A. P., Mountford A. P., Mountford A. P., Mountford A. P., Muchamuel T., Nelms K., Noben-Trauth N., Noben-Trauth N., Noben-Trauth N., O'Garra A., Pearce E. J., Reiner S. L., Scott P., Seder R. A., Sher A., Shibuya K., Smythies L. E., Smythies L. E., Street M., Szabo S. J., Urban J. F., Wilson R. A., Wynn T. A., Wynn T. A., Zurawski G.   +64 more
core   +2 more sources

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

CD28-Dependent CTLA-4 Expression Fine-Tunes the Activation of Human Th17 Cells

iScience, 2020
Summary: Previous work has demonstrated that Th17 memory cells but not Th1 cells are resistant to CD28/CTLA-4 blockade with CTLA-4 Ig, leading us to investigate the individual roles of the CD28 and CTLA-4 cosignaling pathways on Th1 versus Th17 cells. We
Scott M. Krummey, Christina R. Hartigan, Danya Liu, Mandy L. Ford   +3 more
doaj   +1 more source

Combining network modeling and gene expression microarray analysis to explore the dynamics of Th1 and Th2 cell regulation. [PDF]

PLoS Computational Biology, 2010
Two T helper (Th) cell subsets, namely Th1 and Th2 cells, play an important role in inflammatory diseases. The two subsets are thought to counter-regulate each other, and alterations in their balance result in different diseases.
Marco Pedicini, Fredrik Barrenäs, Trevor Clancy, Filippo Castiglione, Eivind Hovig, Kartiek Kanduri, Daniele Santoni, Mikael Benson   +7 more
doaj   +1 more source

Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses [PDF]

, 2008
Alum is used as a vaccine adjuvant and induces T_h2 responses and T_h2-driven antibody isotype production against co-injected antigens.
A. S. McKee, Alving, Atochina, Beutler, Bomford, Brewer, Brewer, Brogdon, Cambier, Crawford, Cunningham, F. Crawford, Gavin, Grun, Grzych, Hoebe, J. W. Kappler, J. White, Jordan, Kaisho, Kane, Kapsenberg, Kawai, Lang, Layland, Li, Liu, M. MacLeod, MacDonald, McDonald, Medzhitov, Mohrs, Morefield, Noben-Trauth, Okano, Ouyang, P. Marrack, Pearce, Pollock, Reese, Schnare, Sokolovska, Steinman, Sun, Trinchieri, Whelan   +45 more
core   +1 more source

Enhanced Human Antigen‐Specific B Cell Responses Using In Vitro 3D Tonsil Cultures Containing Stromal Cells

Advanced Healthcare Materials, EarlyView.
We developed a fully human 3D tonsil cell culture system incorporating supportive stromal cells that better sustains and activates immune cells than conventional methods. The model generates stronger, more targeted antibody responses to viral antigens and vaccines, providing a physiologically relevant and entirely human platform for studying immune ...
Maaike V. J. Braham, Marlon de Gast, Liubov Babii, Sabine Kruijer, Theo M. Bestebroer, Mathilde Richard, Mathieu Claireaux, S. Marieke van Ham, Jelle de Wit, Cécile A. C. M. van Els, Anja ten Brinke, Marit J. van Gils   +11 more
wiley   +1 more source