Results 81 to 90 of about 198,196 (300)

PRMT5 regulates epigenetic changes in suppressive Th1-like iTregs in response to IL-12 treatment

Frontiers in Immunology
BackgroundInduced regulatory T cells (iTregs) are a heterogeneous population of immunosuppressive T cells with therapeutic potential. Treg cells show a range of plasticity and can acquire T effector-like capacities, as is the case for T helper 1 (Th1 ...
Nidhi Jadon, Sudarvili Shanthalingam, Gregory N. Tew, Lisa M. Minter, Lisa M. Minter   +4 more
doaj   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source

Adenosine A2A receptor-mediated interactions between Th1+ T cells and the choroid plexus epithelium via IFN-γ signalling control T-Cell infiltration in experimental autoimmune encephalomyelitis

Cell Communication and Signaling
Background Adenosine A2A receptor (A2AR) antagonists have been consistently demonstrated to protect against multiple sclerosis (MS) pathology, but A2AR knockout (A2AR−/−) mice exhibit exacerbated immune injury, raising concerns regarding the use of A2AR ...
Chenxing Qi, Yuwen Yang, Ping Tang, Cheng Zheng, Xuhang Li, Nan Jiang, Jia Qu, Jiang-Fan Chen, Wu Zheng   +8 more
doaj   +1 more source

T Helper Plasticity Is Orchestrated by STAT3, Bcl6, and Blimp-1 Balancing Pathology and Protection in Malaria

iScience, 2020
Summary: Hybrid Th1/Tfh cells (IFN-γ+IL-21+CXCR5+) predominate in response to several persistent infections. In Plasmodium chabaudi infection, IFN-γ+ T cells control parasitemia, whereas antibody and IL-21+Bcl6+ T cells effect final clearance, suggesting
Victor H. Carpio, Florentin Aussenac, Lucinda Puebla-Clark, Kyle D. Wilson, Alejandro V. Villarino, Alexander L. Dent, Robin Stephens   +6 more
doaj   +1 more source

WT1‐Targeted Oral Bifidobacterium longum Vaccine Enhances Checkpoint Blockade Efficacy in Pancreatic Cancer

Advanced Science, EarlyView.
Oral WT1‐targeted Bifidobacterium longum vaccine promotes WT1‐associated cellular immunity and enhances anti‐PD‐1/anti‐CTLA‐4 efficacy in pancreatic cancer. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains largely unresponsive to immune checkpoint inhibitors (ICI) due to its profoundly immunosuppressive tumor microenvironment.
Taiki Yamazaki, Aori Minami, Misako Hirota, Mirei Hirano, Ryota Sato, Atsuki Honma, Hideto Ueki, Toshiro Shirakawa   +7 more
wiley   +1 more source

IC87114 reduces IFN-γ production by differentiated Th1 cells.

, 2016
Cells isolated from the spleens and lymph nodes of BDC2.5 TCR transgenic NOD mice were differentiated into Th1 cells by culturing them in the presence of anti-CD3/CD28 antibodies, IL-2, IL-12 and IFN-γ for 4 days.
Juliet L. Emery (846592), F. Susan Wong (337457), Klaus Okkenhaug (174378), Anne Cooke (284016), Maja Wallberg (846594), Asha Recino (846593), Ariana Barbera Betancourt (846591)   +6 more
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

CD44 Regulates Survival and Memory Development in Th1 Cells

, 2010
SummaryOptimal immunity to microorganisms depends upon the regulated death of clonally expanded effector cells and the survival of a cohort of cells that become memory cells.
Bas J.G. Baaten, Lin, Melissa M., Cheng-Rui Li, Phyllis J. Linton, Bradley, Linda M., Deiro, Mia F., Baaten, Bas J.G., Linton, Phyllis J., Melissa M. Lin, Li, Cheng-Rui, Mia F. Deiro, Linda M. Bradley   +11 more
core   +1 more source

Astrocytes Modulate the Polarization of CD4+ T Cells to Th1 Cells

PLoS ONE, 2014
T-cell characteristics are dynamic and influenced by multiple factors. To test whether cells and the environment in the central nervous system (CNS) can influence T-cells, we tested if culturing mouse CD4(+) T-cells on mouse primary astrocytes, compared with standard feeder cells, modified T-cell polarization to Th1 and Treg subtypes.
Beurel, Eleonore, Harrington, Laurie E, Buchser, William, Lemmon, Vance, Jope, Richard S   +4 more
openaire   +5 more sources

Targeting Golgi–STING Signaling to Reprogram Innate and Adaptive Immunity for the Treatment of Implant‐Associated Infections

Advanced Science, EarlyView.
This study presents an ultrasound‐responsive nanoplatform, CS‐BT@MZ@NEs, with a BaTiO3/Mn‐Zif‐8 core and a chondroitin sulfate coating for Golgi targeting. By leveraging neutrophil hitchhiking, it enables targeted delivery to infection sites. Under ultrasound stimulation, CS‐BT@MZ@NEs generates ROS and modulates Golgi pH to activate cGAS–STING ...
Shicheng Huo, Naifeng Zhu, Zhuocheng Lyu, Yifei Liu, Zhenjiang Xu, Chun Zhou, Yaochao Zhao, Changgui Shi   +7 more
wiley   +1 more source