Results 71 to 80 of about 320,868 (298)

Requirements for development of T helper 1 and T follicular helper cells from a common precursor

Cell Reports
Summary: T helper (Th) and T follicular helper (Tfh) cells support cellular and humoral immunity, respectively. How activated CD4+ T cells commit to these fates remains unclear.
Douwe M.T. Bosma, Julia Busselaar, Mo D. Staal, Mylène de Koning, Mirna Reljić, Xin Lei, Tom de Wit, Yanling Xiao, Jannie Borst, Fiamma Salerno   +9 more
doaj   +1 more source

Nasal administration of glutamate decarboxylase (GAD65) peptides induces Th2 responses and prevents murine insulin-dependent diabetes. [PDF]

, 1996
We previously demonstrated that a spontaneous Th1 response against glutamate decarboxylase (GAD65) arises in NOD mice at four weeks in age and subsequently T cell autoimmunity spreads both intramolecularly and intermolecularly.
Atkinson, MA, Clare-Salzler, M, Forsthuber, T, Herschenfeld, A, Kaufman, DL, Lehmann, PV, Tian, J   +6 more
core  

Regulation of CD4+NKG2D+ Th1 cells in patients with metastatic melanoma treated with sorafenib : role of IL-15Rα and NKG2D triggering [PDF]

, 2014
Beyond cancer-cell intrinsic factors, the immune status of the host has a prognostic impact on patients with cancer and influences the effects of conventional chemotherapies.
Auperin, Anne, Ayyoub, Maha, Caignard, Anne, Caillat-Zucman, Sophie, Chaba, Kariman, Chaput, Nathalie, Dessen, Philippe, Eggermont, Alexander, Flament, Caroline, Jacquelot, Nicolas, Jacques, Yannick, Mateus, Christine, Messaoudene, Meriem, Mortier, Erwan, Poirier-Colame, Vichnou, Porta, Camillo, Robert, Caroline, Romero, Ana I., Rusakiewicz, Sylvie, Valmor, Danila, Vielh, Philippe, Zitvogel, Laurence   +21 more
core   +2 more sources

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Isoprenoids determine Th1/Th2 fate in pathogenic T cells, providing a mechanism of modulation of autoimmunity by atorvastatin. [PDF]

, 2006
3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase is a critical enzyme in the mevalonate pathway that regulates the biosynthesis of cholesterol as well as isoprenoids that mediate the membrane association of certain GTPases.
Dunn, Shannon E, Goldstein, Matthew J, Prod'homme, Thomas, Steinman, Lawrence, Weber, Martin S, Youssef, Sawsan, Zamvil, Scott S   +6 more
core   +1 more source

Memory Th1 Cells Are Protective in Invasive Staphylococcus aureus Infection [PDF]

, 2015
Mechanisms of protective immunity to Staphylococcus aureus infection in humans remain elusive. While the importance of cellular immunity has been shown in mice, T cell responses in humans have not been characterised.
Brown, A.F. (Aisling), Fennell, J.P. (Jérôme), Fitzgerald-Hughes, D. (Deirdre), Foster, T.J. (Timothy), Geoghegan, J.A. (Joan), Hearnden, C.H. (Claire), Humphreys, H. (Hilary), Lacey, K.A. (Keenan), Lalor, S.J. (Stephen), Lavelle, E.C. (Ed), Leech, J.M. (John), Mac Aogáin, M. (Micheál), McLoughlin, R.M. (Rachel), Murphy, A.G. (Alison), O’Halloran, D.P. (Dara), O’Keeffe, K.M. (Kate), Rogers, T.R. (Thomas), Tavakol, M. (Mehri), Wamel, W.J.B. (Willem) van   +18 more
core   +3 more sources

Opinion: Gavage Administration of MXene as a Route‐Specific Alternative to Intravenous Injection into the Bloodstream of Laboratory Animals for Reducing Systemic Nanotoxicity Risks in Immunosuppression and Post‐Transplantation Models with Bile Acid Modification

Advanced Healthcare Materials, EarlyView.
Recent studies reported immunosuppressive properties of specific MXene nanomaterials. Their intravenous injection into the bloodstream of laboratory animals has been a common delivery method to suppress systemic inflammation and prevent transplant rejection.
Alireza Rafieerad, M. Akif Rahman, Ahmad Amiri   +2 more
wiley   +1 more source

Dose-dependent induction of murine Th1/Th2 responses to sheep red blood cells occurs in two steps: antigen presentation during second encounter is decisive.

PLoS ONE, 2013
The differentiation of CD4 T cells into Th1 and Th2 cells in vivo is difficult to analyze since it is influenced by many factors such as genetic background of the mice, nature of antigen, and adjuvant.
Claudia Stamm, Julia Barthelmann, Natalia Kunz, Kai-Michael Toellner, Jürgen Westermann, Kathrin Kalies   +5 more
doaj   +1 more source

Th1 and Th2 Cells Help CD8 T-Cell Responses [PDF]

Infection and Immunity, 2007
ABSTRACTHelp from CD4 T cells is often important for the establishment of primary and memory CD8 T-cell responses. However, it has yet to be determined whether T helper polarization affects the delivery of help and/or whether responding CD8 T cells helped by Th1 or Th2 cells express distinct effector properties. To address these issues, we compared CD8
Melinda J, Ekkens, Devon J, Shedlock, Euihye, Jung, Amy, Troy, Erika L, Pearce, Hao, Shen, Edward J, Pearce   +6 more
openaire   +2 more sources

Rapid Fabrication of Self‐Propelled and Steerable Magnetic Microcatheters for Precision Medicine

Advanced Materials, EarlyView.
A rapid Joule heating fabrication method for the production of self‐propelling, adaptive microcatheters, with tunable stiffness and integrated microfluidic channels is presented. Demonstrated through three microrobotic designs, including a steerable guiding catheter, an untethered wave‐crawling TubeBot, and a distal‐end propelled microcatheter, it was ...
Zhi Chen, Boris Rivkin, David Castellanos‐Robles, Ivan Soldatov, Lukas Beyer, Mariana Medina‐Sánchez   +5 more
wiley   +1 more source