Results 71 to 80 of about 198,196 (300)

Dose-dependent induction of murine Th1/Th2 responses to sheep red blood cells occurs in two steps: antigen presentation during second encounter is decisive.

PLoS ONE, 2013
The differentiation of CD4 T cells into Th1 and Th2 cells in vivo is difficult to analyze since it is influenced by many factors such as genetic background of the mice, nature of antigen, and adjuvant.
Claudia Stamm, Julia Barthelmann, Natalia Kunz, Kai-Michael Toellner, Jürgen Westermann, Kathrin Kalies   +5 more
doaj   +1 more source

Engineering Immunoregenerative Therapy via an Immunomodulatory Binary Pharmacology Hydrogel Depot for Prolonged Allograft Survival

Advanced Science, EarlyView.
An immunomodulatory hydrogel (iGEL) forms spontaneously upon subcutaneous injection, acting as a tissue‐adhesive depot. It releases anti‐rejection and regenerative agents in response to inflammation, suppressing T‐cell activity, promoting vascular repair, and restoring allograft function without systemic immunosuppression.
Ning Wang, Ruiqi Sun, Yang Fu, Zhonghan Wu, Xinyu Tong, Hong Tang, Wentao Zhao, Zhi Liang, Jintao Zheng, Yanan Guan, Ke Zhou, Penghong Song, Shusen Zheng, Hangxiang Wang, Haiyang Xie   +14 more
wiley   +1 more source

The percentages of circulating Th17 and Th1 cells in patients after treatment.

, 2016
PA means patient. (A and B) The percentages of circulating Th17 and Th1 cells before and after chemotherapy in B-NHL. (C and D) Circulating Th17 cells were significantly increased in treated B-NHL patients compared to those before treatment (P = 0.0098 ...
Ting Lu (149031), Shuang Yu (181261), Congcong Yin (848718), Yan Liu (25061), Daoxin Ma (212170), Zhi Liu (165121), Chunyan Ji (443711), Jingjing Ye (84458)   +7 more
core   +1 more source

Mast Cells Stimulated with Peptidoglycan from Staphylococcus aureus Augment the Development of Th1 Cells

Journal of Pharmacy & Pharmaceutical Sciences, 2018
Background: The skin of patients with atopic dermatitis (AD) is superficially colonized by Staphylococcus aureus. We have previously found that percutaneous permeation of peptidoglycan (PEG) from S. aureus increases the number of mast cells in the dermis,
Katsuhiko Matsui, Saeko Kanai, Manami Ikuta, Saki Horikawa   +3 more
doaj   +1 more source

Targeting METTL3 Attenuates Thyroid Inflammatory Injury by Restoring Th17/Treg Balance through a YTHDC2‐m6A‐Dependent KDR/VEGFA Loop

Advanced Science, EarlyView.
METTL3‐mediated m6A modification stabilizes KDR/Kdr mRNA through YTHDC2, amplifying the VEGFA‐KDR feedback loop and disturbing Th17/Treg balance. This pathway promotes persistent inflammation and tissue damage in patients with AIT, and inhibiting the METTL3‐KDR axis effectively disrupts this circuit, alleviating thyroid tissue injury and disease ...
Qingyi Hu, Huan Liu, Anwen Ren, Zimei Tang, Jie Tan, Wen Yang, Jie Ming, Tao Huang   +7 more
wiley   +1 more source

Locus-Specific Reversible DNA Methylation Regulates Transient IL-10 Expression in Th1 Cells

, 2018
IL-10 is a pleiotropic cytokine with multifaceted functions in establishing immune homeostasis. Although expressed by Th1 and Th2 cells, conventional Th1 cells produce marginal levels of IL-10 compared with their Th2 counterparts.
Zee Yong Park, Hwang, Won, Park ZY, Lee, Choong-Gu, Park, Zee Yong, Ravi Verma, Sin-Hyeog Im, Lee, Changhon, Sin Hyeog Im, Verma, Ravi, Im, Sin-Hyeog, Choong-Gu Lee, Changhon Lee, Dipayan Rudra, Won Hwang, Rudra, Dipayan   +15 more
core   +1 more source

Demethylation of the RORC2 and IL17A in human CD4+ T lymphocytes defines Th17 origin of nonclassic Th1 cells. [PDF]

, 2015
Th17-derived Th1 lymphocytes, termed nonclassic, differ from classic Th1 cells because of the presence of retinoic acid orphan receptor (ROR)C2 and the surface expression of CD161 and CCR6.
Santarlasci V, M. Capone, R. De Palma, Annunziato F., A. Radbruch, S. Romagnani, Mazzoni A, Querci V, V. Querci, Cimaz R, J. Dong, F. Annunziato, H. Chang, Dong J, Romagnani S, Maggi E, Rossi MC, Cosmi L, M. C. Rossi, Liotta F, A. Thiel, Maggi L, Radbruch A, Thiel A, V. Santarlasci, R. Cimaz, L. Maggi, E. Maggi, A. Mazzoni, L. Cosmi, Capone M, F. Liotta, Chang HD, DE PALMA, Raffaele   +33 more
core   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

Interaction of Ets-1 with HDAC1 represses IL-10 expression in Th1 cells

, 2017
IL-10 is a multifunctional cytokine that plays a crucial role in immunity and tolerance. IL-10 is produced by diverse immune cell types, including B cells and subsets of T cells. Although Th1 produce IL-10, their expression levels are much lower than Th2
황은숙
core   +1 more source