Treg-derived IFN-γ supports the differentiation of Th1-Treg in tumor immunity and autoimmunity [PDF]
Frontiers in ImmunologyRegulatory T cells (Tregs) within the tumor microenvironment (TME) exhibit functional heterogeneity, including a Foxp3+T-bet+ subset known as Th1-type Treg (Th1-Treg) cells that exert potent immunosuppressive activity.
Ayumi Kuratani +12 more
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Pathologic Th1–Treg Cells Exacerbate Acute Lung Injury and Lethality in Sepsis [PDF]
CellsSepsis is characterized by dysregulated immune responses induced by damage-associated molecular patterns, such as extracellular cold-inducible RNA-binding protein (eCIRP), that frequently lead to acute lung injury (ALI) and high mortality.
Takuya Murao +3 more
doaj +2 more sources
Longitudinal investigation of the T helper (Th)1-Th2 balance and complement system in clinical high risk for psychosis cohort [PDF]
Translational PsychiatryThe T Helper (Th)1-Th2 imbalance has been observed during the transition from the clinical high-risk (CHR) state to psychosis. However, it remains unclear whether the complement system influences this imbalance during psychosis onset. This study aimed to
TianHong Zhang +17 more
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Common Features of Regulatory T Cell Specialization During Th1 Responses
Frontiers in Immunology, 2018 CD4+Foxp3+ Treg cells are essential for maintaining self-tolerance and preventing excessive immune responses. In the context of Th1 immune responses, co-expression of the Th1 transcription factor T-bet with Foxp3 is essential for Treg cells to control ...
Claudia Moresi +2 more
exaly +3 more sources
Cell Reports, 2017 Recent data indicate that the differentiation state of Th1 cells determines their protective capacity against tuberculosis. Therefore, we examined the role of Th1-polarizing factors in the generation of protective and non-protective subsets of Mtb ...
Shunsuke Sakai +2 more
exaly +3 more sources
Evaluation of IFN-γ and T-bet Expression Levels as Possible Molecular Markers of Schizophrenia [PDF]
Journal of Cell and Molecular Research, 2020 Schizophrenia is an irritating mental disorder that affects around 1% of the world's population. The immune system contributes to the onset of the disease, particularly through production and secretion of some cytokines.
Roghaye Lorestani +3 more
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T helper cell subsets and related target cells in acute COVID-19
Инфекция и иммунитет, 2022 Current review presents a brief overview of the immune system dysregulation during acute COVID-19 and illustrates the main alterations in peripheral blood CD4+ T-cell (Th) subsets as well as related target cells.
I. V. Kudryavtsev +2 more
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Review – Helicobacter: inflammation, immunity and vaccines [PDF]
Microbiota in Health and Disease, 2021 Helicobacter pylori is a bacterium that colonizes the human stomach and is the risk factor for severe gastroduodenal diseases, such as gastric cancer, gastric lymphoma, autoimmune gastritis and peptic ulcer. H.
M. D’Elios, M. de Bernard
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Российский кардиологический журнал, 2022 Aim. To analyze the relationship of blood lipid profile parameters, including the level of lipoprotein(a) (Lp(a)), and the content of circulating CD4+ T-lymphocytes with premature coronary artery disease (CAD).Material and methods.
A. Yu. Filatova +6 more
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Comparative Analysis of Apigenin-3 Acetate versus Apigenin and Methyl-Prednisolone in Inhibiting Proliferation and Gene Expression of Th1 Cells in Multiple Sclerosis [PDF]
Cell Journal, 2023 Objective: In spite of the advances in therapeutic modalities, morbidity, due to multiple sclerosis (MS), still remains high.Therefore, a large body of research is endeavouring to discover or develop novel therapies with improved efficacy fortreating MS ...
Neda Kasiri +7 more
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