Annals of the New York Academy of Sciences, 2010 Autoreactive effector CD4+ T cells have been associated with the pathogenesis of autoimmune disorders. Early studies implicated the interferon (IFN)‐γ‐producing T helper (Th)1 subset of CD4+ cells as the causal agents in the pathogenesis of autoimmunity. However, further studies have suggested a more complex story. In models thought to be driven by Th1
Rachel Caspi
exaly +3 more sources
Evaluation of IFN-γ and T-bet Expression Levels as Possible Molecular Markers of Schizophrenia [PDF]
Journal of Cell and Molecular Research, 2020 Schizophrenia is an irritating mental disorder that affects around 1% of the world's population. The immune system contributes to the onset of the disease, particularly through production and secretion of some cytokines.
Roghaye Lorestani +3 more
doaj +1 more source
T helper cell subsets and related target cells in acute COVID-19
Инфекция и иммунитет, 2022 Current review presents a brief overview of the immune system dysregulation during acute COVID-19 and illustrates the main alterations in peripheral blood CD4+ T-cell (Th) subsets as well as related target cells.
I. V. Kudryavtsev +2 more
doaj +1 more source
Review – Helicobacter: inflammation, immunity and vaccines [PDF]
Microbiota in Health and Disease, 2021 Helicobacter pylori is a bacterium that colonizes the human stomach and is the risk factor for severe gastroduodenal diseases, such as gastric cancer, gastric lymphoma, autoimmune gastritis and peptic ulcer. H.
M. D’Elios, M. de Bernard
doaj +1 more source
Российский кардиологический журнал, 2022 Aim. To analyze the relationship of blood lipid profile parameters, including the level of lipoprotein(a) (Lp(a)), and the content of circulating CD4+ T-lymphocytes with premature coronary artery disease (CAD).Material and methods.
A. Yu. Filatova +6 more
doaj +1 more source
Comparative Analysis of Apigenin-3 Acetate versus Apigenin and Methyl-Prednisolone in Inhibiting Proliferation and Gene Expression of Th1 Cells in Multiple Sclerosis [PDF]
Cell Journal, 2023 Objective: In spite of the advances in therapeutic modalities, morbidity, due to multiple sclerosis (MS), still remains high.Therefore, a large body of research is endeavouring to discover or develop novel therapies with improved efficacy fortreating MS ...
Neda Kasiri +7 more
doaj +1 more source
Game theory applications in host-microbe interactions toward disease manifestation: Mycobacterium tuberculosis infection as an example [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): Game theory describes the interactions between two players and the pay-off from winning, losing, or compromising. In the present study, Mycobacterium tuberculosis (Mtb)–host interactions were used as an example for the application of game ...
Hiva Sharebiani +11 more
doaj +1 more source
Th1-cell epitopes predicted for the Mtb antigens.
, 2022 Th1-cell epitopes predicted for the Mtb antigens.
Mohsina Akhter (13883935) +3 more
core +1 more source
Th1, Th2, and Th17 cytokines in systemic lupus erythematosus
Autoimmunity, 2020 Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the breakdown of immune tolerance leading to excessive inflammation and tissue damage.
Farhana Muhammad Yusoff +2 more
doaj +1 more source
Th1/Th2 Imbalance and Elevated PD-L1 in Pleural Effusion Predict the Risk of Multi-Drug Resistant Tuberculous Pleuritis [PDF]
Iranian Journal of Immunology, 2020 Background: Patient immune status might be indicative of the variance in bacterial genetics in drug-resistant tuberculous pleuritis and could be used for predicting the risk of multi-drug resistant tuberculous pleuritis (MDR-TB).
Hongyan Xu +3 more
doaj +1 more source