Results 21 to 30 of about 451,440 (299)

Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1 [PDF]

, 2014
During the course of many chronic viral infections, the antiviral T cell response becomes attenuated through a process that is regulated in part by the host. While elevated expression of the immunosuppressive cytokine IL-10 is involved in the suppression
Brüstle, Anne, Chen, Jonathan H, Cui, Weiguo, Kaech, Susan M, Laidlaw, Brian J, Lang, Philipp A, Marshall, Heather D, Ohashi, Pamela, Parish, Ian A, Perry, Curtis, Staron, Matthew M, Tsui, Yao-Chen, Weaver, Casey T   +12 more
core   +1 more source

Th1 and Th1-inducing cytokines inSalmonellainfection

Clinical and Experimental Immunology, 2003
SUMMARYThl and Thl-inducing cytokines and T cell responses were investigated in human salmonellosis. Serum IFN-γ, IL-12 and IL-18 levels were increased significantly in patients with salmonellosis. The increase in serum IL-15 and IL-18 levels was more significant and prolonged in patients with the systemic form of salmonellosis than in those with the ...
Y, Mizuno, H, Takada, A, Nomura, C-H, Jin, H, Hattori, K, Ihara, T, Aoki, K, Eguchi, T, Hara   +8 more
openaire   +3 more sources

Tailored design of NKT-stimulatory glycolipids for polarization of immune responses. [PDF]

, 2017
Natural killer T (NKT) cell is a distinct population of T lymphocytes that can rapidly release massive amount of Th1 and Th2 cytokines upon the engagement of their T cell receptor with glycolipids presented by CD1d.
Huang, Jing-Rong, Hung, Jung-Tung, Yu, Alice L   +2 more
core   +2 more sources

Inactivated herpes simplex virus-1 vaccine formulated in aqueous and alcoholic extracts of propolis boosts cellular and IgG responses [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): In this study, the adjuvant activity of aqueous and alcoholic extracts of propolis was examined on the inactivated herpes simplex virus-1 (HSV-1).Materials and Methods: BALB/C mice were administered with inactivated (HSV-1; the KOS strain ...
Sanaz Mojarab, Pegah Karimi, Delavar Shahbazzadeh, Majid Moghbeli, Kamran Pooshang Bagheri, Arezoo Beig Parikhani, Rada Dehghan, Ehsan Zafari, Amir Moravej, Mohammad Hassan Pouriyayevali, Seyedeh Faranak Mirtalebi, Mahdi Pakjoo, Shaghayegh Yazdani, Meghdad Abdollahpour-alitappeh, Mehdi Mahdavi   +14 more
doaj   +1 more source

Immunization with a Bacterial Lipoprotein Establishes an Immuno-Protective Response with Upregulation of Effector CD4+ T Cells and Neutrophils Against Methicillin-Resistant Staphylococcus aureus Infection

Pathogens, 2020
Staphylococcus aureus (S. aureus) is a commensal bacterium in the human body; however, the bacterium frequently generates serious inflammation and infectious diseases. Some strains of S. aureus, such as methicillin-resistant Staphylococcus aureus (MRSA),
Zhenzi Peng, Duo-Yao Cao, Hui-Ya Wu, Suguru Saito   +3 more
doaj   +1 more source

Homotaurine, a safe blood-brain barrier permeable GABAA-R-specific agonist, ameliorates disease in mouse models of multiple sclerosis. [PDF]

, 2018
There is a need for treatments that can safely promote regulatory lymphocyte responses. T cells express GABA receptors (GABAA-Rs) and GABA administration can inhibit Th1-mediated processes such as type 1 diabetes and rheumatoid arthritis in mouse models.
Dang, Hoa, Kaufman, Daniel L, Olsen, Richard, Tian, Jide, Wallner, Martin   +4 more
core   +3 more sources

Kirenol attenuates experimental autoimmune encephalomyelitis by inhibiting differentiation of Th1 and th17 cells and inducing apoptosis of effector T cells. [PDF]

, 2015
Experimental autoimmune encephalomyelitis (EAE), a model of multiple sclerosis (MS), is characterized by CNS demyelination mediated by autoreactive T cells.
Deng, Wenbin, Fan, Xiaohang, Liu, Wenwei, Xiao, Juan, Yang, Lin, Yang, Rongbing   +5 more
core   +5 more sources

Spatiotemporal Cellular Networks Maintain Immune Homeostasis in the Lung

European Medical Journal Respiratory, 2020
A dynamic and intricately connected tissue-resident immune cell network continuously monitors the lungs, which are incessantly subjected to external environmental insults.
Jessica G. Borgeredo
doaj   +1 more source

The attenuation effect of low piperine Piper nigrum extract on doxorubicin-induced toxicity of blood chemical and immunological properties in mammary tumour rats

Pharmaceutical Biology, 2022
Context Many natural extracts have been shown to minimize the toxicity of doxorubicin (Dox). Low piperine Piper nigrum L. (Piperaceae) extract (PFPE) is a natural extract containing many types of antioxidants that may reduce Dox toxicities.
Jirakrit Saetang, Aman Tedasen, Surasak Sangkhathat, Natnaree Sangkaew, Sirinapa Dokduang, Napat Prompat, Siriporn Taraporn, Potchanapond Graidist   +7 more
doaj   +1 more source

Markers of Th1 polarized Th17 cells (literature review)

Acta Biomedica Scientifica, 2023
T helpers (Th) producing IL-17 (Th17) have high plasticity and under the influence of external conditions are able to redifferentiate into cells with a different phenotype, primarily in Th1-lymphocytes, forming a population that combines the ...
E. M. Kuklina, N. S. Glebezdina
doaj   +1 more source