T‐bet Regulates Ion Channels and Transporters and Induces Apoptosis in Intestinal Epithelial Cells [PDF]
Advanced ScienceT‐bet, encoded by TBX21, is extensively expressed across various immune cell types, and orchestrates critical functions in their development, survival, and physiological activities.
Lang Chen +8 more
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Inducible T-bet deletion reveals tissue-specific requirements in NKp46+ ILC immunobiology and response to murine cytomegalovirus [PDF]
Nature CommunicationsThe requirement for the T-box transcription factors (TF) T-bet and Eomes in innate lymphoid cells (ILCs) beyond their development is not well understood.
Pamela Wong +24 more
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Identification of the T-box transcription factor t-bet in chickens and its role in immune response [PDF]
Poultry ScienceT-bet (T-box transcription factor TBX21), encoded by the Tbx21 gene, is a key regulator of T helper 1 (Th1) cell differentiation and cellular immunity. However, the role of T-bet in avian species remains elusive. To investigate the role of T-bet in avian
Yuxin Guo +9 more
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The effect of glatiramer acetate, IFNβ-1a, fingolimod, and dimethyl fumarate on the expression of T-bet, IFN-γ, and MEG3 in PBMC of RRMS patients [PDF]
BMC Research Notes, 2023 Objective Multiple sclerosis (MS) is a progressing neurodegenerative disease marked by chronic central nervous system inflammation and degeneration.This study investigates gene expression profiles of T-box transcription factor TBX21 (T-bet), interferon ...
Rozhin Dabbaghi +6 more
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Vaccine adjuvant-elicited CD8+ T cell immunity is co-dependent on T-bet and FOXO1 [PDF]
Cell Reports, 2023 Summary: T-bet and FOXO1 are transcription factors canonically associated with effector and memory T cell fates, respectively. During an infectious response, these factors direct the development of CD8+ T cell fates, where T-bet deficiency leads to ...
Daria L. Ivanova +8 more
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T-BET and EOMES sustain mature human NK cell identity and antitumor function [PDF]
The Journal of Clinical Investigation, 2023 Since the T-box transcription factors (TFs) T-BET and EOMES are necessary for initiation of NK cell development, their ongoing requirement for mature NK cell homeostasis, function, and molecular programming remains unclear.
Pamela Wong +27 more
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T-bet overexpression enhances CAR T cell effector functions and antigen sensitivity [PDF]
Journal for ImmunoTherapy of CancerBackground T cells modified to express a chimeric antigen receptor (CAR) are successful against B-lineage malignancies but fail to induce durable remissions in up to half of patients and have shown limited efficacy against other types of cancer ...
M. Eric Kohler +7 more
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Evaluation of IFN-γ and T-bet Expression Levels as Possible Molecular Markers of Schizophrenia [PDF]
Journal of Cell and Molecular Research, 2020 Schizophrenia is an irritating mental disorder that affects around 1% of the world's population. The immune system contributes to the onset of the disease, particularly through production and secretion of some cytokines.
Roghaye Lorestani +3 more
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Сучасна педіатрія: Україна, 2022 Некротизуючий ентероколіт (НЕК) - тяжке гастроінтестинальне захворювання, що уражує переважно недоношених немовлят. Неспецифічність клінічної картини та високий відсоток ускладнень обумовлюють необхідність ранньої діагностики та профілактики захворювання.
O.E. Abaturov, A.O. Tovarnytska
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Frontiers in Immunology, 2021 T-bet, a T-box family member, is a transcription factor essential for the differentiation of naive CD4+ T cells into Th1 cells that are involved in both innate and adaptive immune responses.
Hongfei Tian +8 more
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