T-bet controls severity of hypersensitivity pneumonitis [PDF]
Journal of Inflammation, 2011 Hypersensitivity Pneumonitis (HP) is an interstitial lung disease that develops following repeated exposure to inhaled environmental antigens. The disease is characterized by alveolitis, granuloma formation and in some patients' fibrosis.
Nance Stephanie C +3 more
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Inducible T-bet deletion reveals tissue-specific requirements in NKp46+ ILC immunobiology and response to murine cytomegalovirus [PDF]
Nature CommunicationsThe requirement for the T-box transcription factors (TF) T-bet and Eomes in innate lymphoid cells (ILCs) beyond their development is not well understood.
Pamela Wong +24 more
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Identification of the T-box transcription factor t-bet in chickens and its role in immune response [PDF]
Poultry ScienceT-bet (T-box transcription factor TBX21), encoded by the Tbx21 gene, is a key regulator of T helper 1 (Th1) cell differentiation and cellular immunity. However, the role of T-bet in avian species remains elusive. To investigate the role of T-bet in avian
Yuxin Guo +9 more
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T-bet + B Cells in Humans: Protective and Pathologic Functions. [PDF]
Transplantation, 2023 The humoral immune system comprises B cells and plasma cells, which play important roles in organ transplantation, ranging from the production of both protective and injurious antibodies as well as cytokines that can promote operational tolerance. Recent data from conditions outside of transplantation have identified a novel human B-cell subset that ...
Nellore A, Zumaquero E, Seifert M.
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The effect of glatiramer acetate, IFNβ-1a, fingolimod, and dimethyl fumarate on the expression of T-bet, IFN-γ, and MEG3 in PBMC of RRMS patients [PDF]
BMC Research Notes, 2023 Objective Multiple sclerosis (MS) is a progressing neurodegenerative disease marked by chronic central nervous system inflammation and degeneration.This study investigates gene expression profiles of T-box transcription factor TBX21 (T-bet), interferon ...
Rozhin Dabbaghi +6 more
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T‐bet Regulates Ion Channels and Transporters and Induces Apoptosis in Intestinal Epithelial Cells [PDF]
Advanced ScienceT‐bet, encoded by TBX21, is extensively expressed across various immune cell types, and orchestrates critical functions in their development, survival, and physiological activities.
Lang Chen +8 more
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Vaccine adjuvant-elicited CD8+ T cell immunity is co-dependent on T-bet and FOXO1 [PDF]
Cell Reports, 2023 Summary: T-bet and FOXO1 are transcription factors canonically associated with effector and memory T cell fates, respectively. During an infectious response, these factors direct the development of CD8+ T cell fates, where T-bet deficiency leads to ...
Daria L. Ivanova +8 more
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Expression Regulation and Function of T-Bet in NK Cells. [PDF]
Front Immunol, 2021 Natural killer (NK) cells are cytotoxic innate lymphocytes that play an important role in immune surveillance. The development, maturation and effector functions of NK cells are orchestrated by the T-box transcription factor T-bet, whose expression is induced by cytokines such as IFN-γ, IL-12, IL-15 and IL-21 through the respective cytokine receptors ...
Huang C, Bi J.
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T-BET and EOMES sustain mature human NK cell identity and antitumor function [PDF]
The Journal of Clinical Investigation, 2023 Since the T-box transcription factors (TFs) T-BET and EOMES are necessary for initiation of NK cell development, their ongoing requirement for mature NK cell homeostasis, function, and molecular programming remains unclear.
Pamela Wong +27 more
doaj +2 more sources
T-bet overexpression enhances CAR T cell effector functions and antigen sensitivity [PDF]
Journal for ImmunoTherapy of CancerBackground T cells modified to express a chimeric antigen receptor (CAR) are successful against B-lineage malignancies but fail to induce durable remissions in up to half of patients and have shown limited efficacy against other types of cancer ...
M. Eric Kohler +7 more
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