Targeted Inhibition of GATA-3 by Pyrrothiogatain: Implications for Adipocyte Biology and Inflammatory Response [PDF]
CellsGATA-3 is a master regulator of preadipocyte differentiation and function. Pharmacological or genetic targeting of GATA-3 will allow us to understand the function of GATA-3 in regulating metabolism, insulin signaling, and inflammation. Pyrrothiogatain, a
Shamma Almuraikhy +5 more
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GATA-3 expression and its correlation with prognostic factors and survival in canine mammary tumors [PDF]
Frontiers in Veterinary Science, 2023 IntroductionThe transcription factor GATA-3 plays a significant role in mammary gland development and differentiation. Recent studies on human oncology have demonstrated its association with favorable pathologic factors in breast cancer.
Gabriel Saraiva Diniz-Gonçalves +12 more
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Long non‐coding RNA MALAT1 promotes Th2 differentiation by regulating microRNA‐135b‐5p/GATA‐3 axis in children with allergic rhinitis [PDF]
Kaohsiung Journal of Medical Sciences, 2022 Allergic rhinitis (AR) threatens patient survival. CD4+ T cells play key roles in AR progression. Long non‐coding RNAs (lncRNAs) are key regulators of cell differentiation.
Xiong‐Hui Wu +5 more
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GATA-3 expression in breast cancer is related to intratumoral M2 macrophage infiltration and tumor differentiation. [PDF]
PLoS ONE, 2023 Accumulating evidence indicates that tumor-associated macrophages promote tumor progression and that high macrophage infiltration is correlated with advanced tumor stages and poor prognosis in breast cancer.
Husam Oda +3 more
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Effects of crocin on T-bet/GATA-3 ratio, and miR-146a and miR-106a expression levels in lung tissue of ovalbumin-sensitized mice [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Although various studies have revealed the beneficial effects of crocin (derived from saffron), such as anti-inflammatory, anti-cancer, antioxidant, and immune modulator, however, its exact mechanism is unknown.
Mohammad Reza Aslani +5 more
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GATA-3 is a proto-oncogene in T-cell lymphoproliferative neoplasms [PDF]
Blood Cancer Journal, 2022 Neoplasms originating from thymic T-cell progenitors and post-thymic mature T-cell subsets account for a minority of lymphoproliferative neoplasms. These T-cell derived neoplasms, while molecularly and genetically heterogeneous, exploit transcription ...
Xiangrong Geng +35 more
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CDK9 is a dependency in GATA-3 driven and MCL-1 independent T-cell Lymphomas [PDF]
Blood Cancer JournalThe transcription factor GATA-binding protein 3 (GATA-3) regulates oncogenic transcriptional programs across diverse T-cell lymphomas, including subsets of both peripheral and primary cutaneous T-cell lymphomas.
Chenguang Wang +13 more
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Overexpression of T-bet, GATA-3 and TGF-ß Induces IFN-γ, IL-4/13A, and IL-17A Expression in Atlantic Salmon [PDF]
Biology, 2020 The overexpression of GATA-3, T-bet and TGF-ß may theoretically induce IL-4/A, IFN-γ and IL-17A expression, respectively. Whether this also applies to fish is not yet known.
Tiril H. Slettjord +6 more
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Interaction between ANXA1 and GATA-3 in Immunosuppression of CD4+ T Cells [PDF]
Mediators of Inflammation, 2016 Decreased Th1/Th2 ratio is one of the major characteristics of immunosuppression in sepsis. Both membrane adhesive protein Annexin-A1 (ANXA1) and transcription factor GATA-3 have been reported to play important roles in T cell differentiation.
Peng Huang +3 more
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Caveolin-1, GATA-3, and Ki67 expressions and their correlation with pathological findings in canine bladder urothelial carcinoma [PDF]
Frontiers in Veterinary Science, 2022 The bladder urothelial carcinoma (UC) represents ~2% of malignant neoplasms in dogs and is a therapeutic challenge in veterinary medicine. Although it is considered the most common bladder cancer in dogs, few previous studies have investigated different ...
Verônica Mollica Govoni +9 more
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