GATA‐3 expression in primary pure choriocarcinoma of the bladder [PDF]
IJU Case Reports, 2020 Introduction Primary pure choriocarcinoma of the bladder is extremely rare and should be distinguished from urothelial carcinoma. GATA‐3 is a zinc finger transcription factor and a known sensitive immunostaining marker for urothelial carcinoma.
Mayuka Shinohara +3 more
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GATA-3 expression and its correlation with prognostic factors and survival in canine mammary tumors [PDF]
Frontiers in Veterinary Science, 2023 IntroductionThe transcription factor GATA-3 plays a significant role in mammary gland development and differentiation. Recent studies on human oncology have demonstrated its association with favorable pathologic factors in breast cancer.
Gabriel Saraiva Diniz-Gonçalves +12 more
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Long non‐coding RNA MALAT1 promotes Th2 differentiation by regulating microRNA‐135b‐5p/GATA‐3 axis in children with allergic rhinitis [PDF]
Kaohsiung Journal of Medical Sciences, 2022 Allergic rhinitis (AR) threatens patient survival. CD4+ T cells play key roles in AR progression. Long non‐coding RNAs (lncRNAs) are key regulators of cell differentiation.
Xiong‐Hui Wu +5 more
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Effects of crocin on T-bet/GATA-3 ratio, and miR-146a and miR-106a expression levels in lung tissue of ovalbumin-sensitized mice [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Although various studies have revealed the beneficial effects of crocin (derived from saffron), such as anti-inflammatory, anti-cancer, antioxidant, and immune modulator, however, its exact mechanism is unknown.
Mohammad Reza Aslani +5 more
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GATA-3 expression in breast cancer is related to intratumoral M2 macrophage infiltration and tumor differentiation [PDF]
PLoS ONE, 2023 Accumulating evidence indicates that tumor-associated macrophages promote tumor progression and that high macrophage infiltration is correlated with advanced tumor stages and poor prognosis in breast cancer.
Husam Oda +3 more
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GATA-3 is a proto-oncogene in T-cell lymphoproliferative neoplasms [PDF]
Blood Cancer Journal, 2022 Neoplasms originating from thymic T-cell progenitors and post-thymic mature T-cell subsets account for a minority of lymphoproliferative neoplasms. These T-cell derived neoplasms, while molecularly and genetically heterogeneous, exploit transcription ...
Xiangrong Geng +35 more
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GATA-3 in T-cell lymphoproliferative disorders. [PDF]
IUBMB Life, 2020 AbstractGATA‐3 regulates the differentiation, proliferation, survival, and function of peripheral T cells and their thymic progenitors. Recent findings, reviewed here, not only implicate GATA‐3 in the pathogenesis of molecularly, genetically, and clinically distinct T‐cell lymphoproliferative disorders, but also have significant diagnostic, prognostic,
Murga-Zamalloa C, Wilcox RA.
europepmc +5 more sources
Targeted Inhibition of GATA-3 by Pyrrothiogatain: Implications for Adipocyte Biology and Inflammatory Response [PDF]
CellsGATA-3 is a master regulator of preadipocyte differentiation and function. Pharmacological or genetic targeting of GATA-3 will allow us to understand the function of GATA-3 in regulating metabolism, insulin signaling, and inflammation. Pyrrothiogatain, a
Shamma Almuraikhy +5 more
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CDK9 is a dependency in GATA-3 driven and MCL-1 independent T-cell Lymphomas [PDF]
Blood Cancer JournalThe transcription factor GATA-binding protein 3 (GATA-3) regulates oncogenic transcriptional programs across diverse T-cell lymphomas, including subsets of both peripheral and primary cutaneous T-cell lymphomas.
Chenguang Wang +13 more
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Overexpression of T-bet, GATA-3 and TGF-ß Induces IFN-γ, IL-4/13A, and IL-17A Expression in Atlantic Salmon [PDF]
Biology, 2020 The overexpression of GATA-3, T-bet and TGF-ß may theoretically induce IL-4/A, IFN-γ and IL-17A expression, respectively. Whether this also applies to fish is not yet known.
Tiril H. Slettjord +6 more
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