Results 1 to 10 of about 897,116 (253)
Five hTRPA1 Agonists Found in Indigenous Korean Mint, Agastache rugosa. [PDF]
PLoS ONE, 2015 Transient receptor potential ankyrin1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1) are members of the TRP superfamily of structurally related, nonselective cation channels and mediators of several signaling pathways.
Hana Moon +8 more
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Programmable RNA detection with CRISPR-Cas12a
Nature Communications, 2023 Cas12a, a CRISPR-associated protein complex, has an inherent ability to cleave DNA substrates and is utilized in diagnostic tools to identify DNA molecules. We demonstrate that multiple orthologs of Cas12a activate trans-cleavage in the presence of split
Santosh R. Rananaware +8 more
doaj +1 more source
mRNA trans-splicing dual AAV vectors for (epi)genome editing and gene therapy
Nature Communications, 2023 Large genes including several CRISPR-Cas modules like gene activators (CRISPRa) require dual adeno-associated viral (AAV) vectors for an efficient in vivo delivery and expression.
Lisa Maria Riedmayr +20 more
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Gene activation by a CRISPR-assisted trans enhancer
eLife, 2019 The deactivated CRISPR/Cas9 (dCas9) is now the most widely used gene activator. However, current dCas9-based gene activators are still limited by their unsatisfactory activity.
Xinhui Xu +5 more
doaj +1 more source
Structural basis of Janus kinase trans-activation
Cell Reports, 2023 Janus kinases (JAKs) mediate signal transduction downstream of cytokine receptors. Cytokine-dependent dimerization is conveyed across the cell membrane to drive JAK dimerization, trans-phosphorylation, and activation. Activated JAKs in turn phosphorylate receptor intracellular domains (ICDs), resulting in the recruitment, phosphorylation, and ...
Nathanael A. Caveney +6 more
openaire +3 more sources
Signal Transduction and Targeted Therapy, 2023 Cancer cell receives extracellular signal inputs to obtain a stem-like status, yet how tumor microenvironmental (TME) neural signals steer cancer stemness to establish the hierarchical tumor architectures remains elusive.
Bin He +22 more
doaj +1 more source
RNF12 activates Xist and is essential for X chromosome inactivation. [PDF]
PLoS Genetics, 2011 In somatic cells of female placental mammals, one of the two X chromosomes is transcriptionally silenced to accomplish an equal dose of X-encoded gene products in males and females.
Tahsin Stefan Barakat +9 more
doaj +1 more source
A Novel Method for Gene-Specific Enhancement of Protein Translation by Targeting 5'UTRs of Selected Tumor Suppressors. [PDF]
PLoS ONE, 2016 BACKGROUND:Translational control is a mechanism of protein synthesis regulation emerging as an important target for new therapeutics. Naturally occurring microRNAs and synthetic small inhibitory RNAs (siRNAs) are the most recognized regulatory molecules ...
Adam Master +5 more
doaj +1 more source
An emerging and variant viral promoter of HIV-1 subtype C exhibits low-level gene expression noise
Retrovirology, 2021 Background We observe the emergence of several promoter-variant viral strains in India during recent years. The variant viral promoters contain additional copies of transcription factor binding sites present in the viral modulatory region or enhancer ...
Haider Ali +7 more
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The cAMP Inducers Modify N-Acetylaspartate Metabolism in Wistar Rat Brain
Antioxidants, 2021 Neuronal N-acetylaspartate production appears in the presence of aspartate N-acetyltransferase (NAT8L) and binds acetyl groups from acetyl-CoA with aspartic acid.
Robert Kowalski +5 more
doaj +1 more source