Results 1 to 10 of about 54,904 (301)

Transcriptional responses to proteotoxic stressors are profoundly diverse and tissue-specific [PDF]

Cell Stress & Chaperones
Cells counteract proteotoxic conditions by launching transcriptional stress responses. While synthesis of heat shock proteins (HSPs) upon acute stress is well characterized, how distinct proteotoxic conditions reshape the transcriptome remains poorly ...
Adelina Rabenius, Intisar Salim, Hilmar Lindström, Anastasiya Pak, Serhat Aktay, Anniina Vihervaara   +5 more
doaj   +2 more sources

Liver fat storage is controlled by HNF4α through induction of lipophagy and is reversed by a potent HNF4α agonist

Cell Death and Disease, 2021
We report the discovery of strong HNF4α agonists and their use to uncover a previously unknown pathway by which HNF4α controls the level of fat storage in the liver.
Seung-Hee Lee, Vimal Veeriah, Fred Levine   +2 more
doaj   +1 more source

Transcriptomic effects of Tet-on and mifepristone-inducible systems in mouse liver [PDF]

, 2008
Control of transgene expression from long-term expression vectors can be achieved with inducible and regulated promoters. The two most commonly used inducible systems employ doxycycline or mifepristone as the drug activating a silent trans-activator ...
Kramer, M.G. (María Gabriela), Prieto, J. (Jesús), Reboredo, M. (Mercedes), Rivas, J. (Javier) de las, Smerdou, C. (Cristian)   +4 more
core   +4 more sources

Fumarate analogs act as allosteric inhibitors of the human mitochondrial NAD(P)+-dependent malic enzyme. [PDF]

PLoS ONE, 2014
Human mitochondrial NAD(P)+-dependent malic enzyme (m-NAD(P)-ME) is allosterically activated by the four-carbon trans dicarboxylic acid, fumarate. Previous studies have suggested that the dicarboxylic acid in a trans conformation around the carbon-carbon
Ju-Yi Hsieh, Jyung-Hurng Liu, Pai-Chun Yang, Chi-Li Lin, Guang-Yaw Liu, Hui-Chih Hung   +5 more
doaj   +1 more source

ZmOrphan94 Transcription Factor Downregulates ZmPEPC1 Gene Expression in Maize Bundle Sheath Cells

Frontiers in Plant Science, 2021
Spatial separation of the photosynthetic reactions is a key feature of C4 metabolism. In most C4 plants, this separation requires compartmentation of photosynthetic enzymes between mesophyll (M) and bundle sheath (BS) cells.
Alicja M. Górska, Alicja M. Górska, Paulo Gouveia, Paulo Gouveia, Ana Rita Borba, Ana Rita Borba, Anna Zimmermann, Anna Zimmermann, Anna Zimmermann, Tânia S. Serra, Tânia S. Serra, Pedro Carvalho, Tiago F. Lourenço, Tiago F. Lourenço, M. Margarida Oliveira, M. Margarida Oliveira, Christoph Peterhänsel, Nelson J. M. Saibo, Nelson J. M. Saibo   +18 more
doaj   +1 more source

Genome-wide characterization of FK506-binding proteins, parvulins and phospho-tyrosyl phosphatase activators in wheat and their regulation by heat stress

Frontiers in Plant Science, 2022
Peptidyl-prolyl cis-trans isomerases (PPIases) are ubiquitous proteins which are essential for cis-trans isomerisation of peptide bonds preceding the proline residue.
Anantika Suri, Harpreet Singh, Kirandeep Kaur, Anish Kaachra, Prabhjeet Singh   +4 more
doaj   +1 more source

Genome-wide characterization of peptidyl-prolyl  cis–trans  isomerases in Penicillium and their regulation by salt stress in a halotolerant P. oxalicum

Scientific Reports, 2021
Peptidyl-prolyl cis–trans isomerases (PPIases) are the only class of enzymes capable of cis–trans isomerization of the prolyl peptide bond. The PPIases, comprising of different families viz., cyclophilins, FK506-binding proteins (FKBPs), parvulins and ...
Mangaljeet Singh, Kirandeep Kaur, Avinash Sharma, Rajvir Kaur, Dimple Joshi, Megha Chatterjee, Iman Dandapath, Amarjeet Kaur, Harpreet Singh, Prabhjeet Singh   +9 more
doaj   +1 more source

Cis and trans effects differentially contribute to the evolution of promoters and enhancers

Genome Biology, 2020
Background Gene expression differences between species are driven by both cis and trans effects. Whereas cis effects are caused by genetic variants located on the same DNA molecule as the target gene, trans effects are due to genetic variants that affect
Kaia Mattioli, Winona Oliveros, Chiara Gerhardinger, Daniel Andergassen, Philipp G. Maass, John L. Rinn, Marta Melé   +6 more
doaj   +1 more source

Accumulation of unacetylatable Snf2p at the INO1 promoter is detrimental to remodeler recycling supply for CUP1 induction.

PLoS ONE, 2020
Chromatin structure plays a decisive role in gene regulation through the actions of transcriptional activators, coactivators, and epigenetic machinery.
Michelle Esposito, Goldie Libby Sherr, Anthony Esposito, George Kaluski, Farris Ellington, Chang-Hui Shen   +5 more
doaj   +1 more source

Five hTRPA1 Agonists Found in Indigenous Korean Mint, Agastache rugosa. [PDF]

PLoS ONE, 2015
Transient receptor potential ankyrin1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1) are members of the TRP superfamily of structurally related, nonselective cation channels and mediators of several signaling pathways.
Hana Moon, Min Jung Kim, Hee Jin Son, Hae-Jin Kweon, Jung Tae Kim, Yiseul Kim, Jaewon Shim, Byung-Chang Suh, Mee-Ra Rhyu   +8 more
doaj   +1 more source