Results 41 to 50 of about 54,904 (301)

Identification and function of human cytomegalovirus microRNAs [PDF]

, 2008
microRNAs are an extensive class of non-coding genes that regulate gene expression through post-transcriptional repression. These small RNAs are evolutionarily conserved and are likely to be a basic mechanism of gene regulation present within most ...
Bartel, Bernstein, Brennecke, Burnside, Cai, Cai, Cui, Doench, Dunn, Dunn, Elbashir, Elbashir, Enright, Finn Grey, Greaves, Grey, Grey, Grishok, Gupta, Hammond, Hutvagner, Hutvagner, Jay Nelson, John, Johnston, Ketting, Lee, Lee, Lee, Lim, Lu, Lund, Mocarski, Mourelatos, Pfeffer, Pfeffer, Rhoades, Samols, Sano, Simon, Stenberg, Stenberg, Stenberg, Stenberg, Stern-Ginossar, Sullivan, White, White, Wightman, Yang, Yao, Yekta, Yi, Zeng   +53 more
core   +2 more sources

Lineage and fate of each blastomere of the eight-cell sea urchin embryo [PDF]

, 1987
A fluoresceinated lineage tracer was injected into individual blastomeres of eight-cell sea urchin (Strongylocentrotus purpuratus) embryos, and the location of the progeny of each blastomere was determined in the fully developed pluteus.
Britten, Roy J., Cameron, R. Andrew, Davidson, Eric H., Hough-Evans, Barbara R.   +3 more
core   +1 more source

Trans-activation of heparanase promoter by ETS transcription factors [PDF]

Oncogene, 2003
The remodeling of extracellular matrix (ECM) is an important process required for cancer cells to turn into invasive and metastatic cancer cells. To dissolve the protein components of ECM, matrix metalloproteinases are some of the essential enzymes. Another ECM remodeling enzyme is the heparanase (Hpa) that digests the heparin sulfate component of the ...
W C, Lu, Y N, Liu, B B, Kang, J H, Chen
openaire   +2 more sources

Neuronal glucose transporter isoform 3 deficient mice demonstrate features of autism spectrum disorders. [PDF]

, 2010
Neuronal glucose transporter (GLUT) isoform 3 deficiency in null heterozygous mice led to abnormal spatial learning and working memory but normal acquisition and retrieval during contextual conditioning, abnormal cognitive flexibility with intact gross ...
Devaskar, SU, Ehninger, D, Fung, C, Sankar, R, Shin, B-C, Shin, D, Silva, A, Thamotharan, S, Zhao, Y   +8 more
core   +2 more sources

Conservation of the TRAPPII-specific subunits of a Ypt/Rab exchanger complex

BMC Evolutionary Biology, 2007
Background Ypt/Rab GTPases and their GEF activators regulate intra-cellular trafficking in all eukaryotic cells. In S. cerivisiae, the modular TRAPP complex acts as a GEF for the Golgi gatekeepers: Ypt1 and the functional pair Ypt31/32.
Yoo Eunice, Chen Shu, Cox Randal, Segev Nava   +3 more
doaj   +1 more source

Towards combinatorial transcriptional engineering [PDF]

, 2017
The modular nature of the transcriptional unit makes it pos sible to design robust modules with predictable input -output characteristics using a ‘parts - off a shelf’ approach.
Kanodia, Harsh, Loake, Gary, Mehrotra, Rajesh, Mehrotra, Sandhya, Renganaath, Kaushik   +4 more
core   +1 more source

EPAS1 trans-Activation during Hypoxia Requires p42/p44 MAPK [PDF]

Journal of Biological Chemistry, 1999
Hypoxia is a common environmental stress that regulates gene expression and cell function. A number of hypoxia-regulated transcription factors have been identified and have been shown to play critical roles in mediating cellular responses to hypoxia. One of these is the endothelial PAS-domain protein 1 (EPAS1/HIF2-alpha/HLF/HRF).
P W, Conrad, T L, Freeman, D, Beitner-Johnson, D E, Millhorn   +3 more
openaire   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

The Skn7 Response Regulator of \u3ci\u3eSaccharomyces cerevisiae\u3c/i\u3e Interacts with Hsf1 In Vivo and Is Required for the Induction of Heat Shock Genes by Oxidative Stress [PDF]

, 2000
The Skn7 response regulator has previously been shown to play a role in the induction of stress-responsive genes in yeast, e.g., in the induction of the thioredoxin gene in response to hydrogen peroxide.
Erkine, Alexander M., Gross, David S., Johnson, Anthony L., Johnston, Leland H., Makino, Kozo, Morgan, Brian, Raitt, Desmond C.   +6 more
core   +1 more source