Results 21 to 30 of about 807,180 (300)
Intranuclear topological distribution of HIV‐1 trans‐activators [PDF]
FEBS Letters, 1992 Subcellular localization of human immunodeficiency virus type 1 (HIV‐1) Tat and Rev was examined using a confocal laser scanning microscope (CLSM). In transfected COS‐7 cells, Tat resided exclusively in the perinocleolar region, while Rev infiltrated fully into the nucleoli.
Miyazaki, Yukio +4 more
openaire +2 more sources
A Novel Method for Gene-Specific Enhancement of Protein Translation by Targeting 5'UTRs of Selected Tumor Suppressors. [PDF]
PLoS ONE, 2016 BACKGROUND:Translational control is a mechanism of protein synthesis regulation emerging as an important target for new therapeutics. Naturally occurring microRNAs and synthetic small inhibitory RNAs (siRNAs) are the most recognized regulatory molecules ...
Adam Master +5 more
doaj +1 more source
An emerging and variant viral promoter of HIV-1 subtype C exhibits low-level gene expression noise
Retrovirology, 2021 Background We observe the emergence of several promoter-variant viral strains in India during recent years. The variant viral promoters contain additional copies of transcription factor binding sites present in the viral modulatory region or enhancer ...
Haider Ali +7 more
doaj +1 more source
The cAMP Inducers Modify N-Acetylaspartate Metabolism in Wistar Rat Brain
Antioxidants, 2021 Neuronal N-acetylaspartate production appears in the presence of aspartate N-acetyltransferase (NAT8L) and binds acetyl groups from acetyl-CoA with aspartic acid.
Robert Kowalski +5 more
doaj +1 more source
Insects, 2021 Small heat shock proteins (sHSPs) are members of the heat shock protein (HSP) family that play an important role in temperature stress, and heat shock factors (HSFs) are transcriptional activators that regulate HSP expression. Cotesia chilonis, the major
Fu-Jing He +3 more
doaj +1 more source
Trans Time: Safety, Privacy, and Content Warnings on a Transgender-Specific Social Media Site [PDF]
, 2020 Trans people often use social media to connect with others, find and share resources, and post transition-related content. However, because most social media platforms are not built with trans people in mind and because online networks include people who
Haimson, Oliver L. +5 more
core +1 more source
Cross regulation of sirtuin 1, AMPK, and PPARγ in conjugated linoleic acid treated adipocytes. [PDF]
PLoS ONE, 2012 Trans-10, cis-12 conjugated linoleic acid (t10c12 CLA) reduces triglyceride (TG) levels in adipocytes through multiple pathways, with AMP-activated protein kinase (AMPK) generally facilitating, and peroxisome proliferator-activated receptor γ (PPARγ ...
Shan Jiang +3 more
doaj +1 more source
Mechanisms of stimulation of SAGA-mediated nucleosome acetylation by a transcriptional activator
Biochemistry and Biophysics Reports, 2021 Eukaryotic gene expression requires the coordination of multiple factors to overcome the repressive nature of chromatin. However, the mechanistic details of this coordination are not well understood.
Sannie J. Culbertson +1 more
doaj +1 more source
Cis- and Trans-Activation of Hormone Receptors: the LH Receptor [PDF]
Molecular Endocrinology, 2002 AbstractG protein-coupled receptors (GPCRs) accommodate a wide spectrum of activators from ions to glycoprotein hormones. The mechanism of activation for this large and clinically important family of receptors is poorly understood. Although initially thought to function as monomers, there is a growing body of evidence that GPCR dimers form, and in some
Inhae, Ji +4 more
openaire +2 more sources