Results 11 to 20 of about 54,904 (301)
FSHR Trans-Activation and Oligomerization [PDF]
Frontiers in Endocrinology, 2018 Follicle stimulating hormone (FSH) plays a key role in human reproduction through, among others, induction of spermatogenesis in men and production of estrogen in women. The function FSH is performed upon binding to its cognate receptor-follicle-stimulating hormone receptor (FSHR) expressed on the surface of target cells (granulosa and Sertoli cells ...
Kamila Szymańska +7 more
openaire +3 more sources
Structural basis of Janus kinase trans-activation
Cell Reports, 2023 Janus kinases (JAKs) mediate signal transduction downstream of cytokine receptors. Cytokine-dependent dimerization is conveyed across the cell membrane to drive JAK dimerization, trans-phosphorylation, and activation. Activated JAKs in turn phosphorylate receptor intracellular domains (ICDs), resulting in the recruitment, phosphorylation, and ...
Nathanael A. Caveney +6 more
openaire +3 more sources
Trans-activating mutations of the pseudokinase ERBB3
Oncogene, 2023 Abstract Genetic changes in the ERBB family of receptor tyrosine kinases serve as oncogenic driver events and predictive biomarkers for ERBB inhibitor drugs. ERBB3 is a pseudokinase member of the family that, although lacking a fully active kinase domain, is well known for its potent signaling activity as a heterodimeric complex with ERBB2 ...
Marika K. A. Koivu +5 more
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mRNA trans-splicing dual AAV vectors for (epi)genome editing and gene therapy
Nature Communications, 2023 Large genes including several CRISPR-Cas modules like gene activators (CRISPRa) require dual adeno-associated viral (AAV) vectors for an efficient in vivo delivery and expression.
Lisa Maria Riedmayr +20 more
doaj +1 more source
Programmable RNA detection with CRISPR-Cas12a
Nature Communications, 2023 Cas12a, a CRISPR-associated protein complex, has an inherent ability to cleave DNA substrates and is utilized in diagnostic tools to identify DNA molecules. We demonstrate that multiple orthologs of Cas12a activate trans-cleavage in the presence of split
Santosh R. Rananaware +8 more
doaj +1 more source
Gene activation by a CRISPR-assisted trans enhancer
eLife, 2019 The deactivated CRISPR/Cas9 (dCas9) is now the most widely used gene activator. However, current dCas9-based gene activators are still limited by their unsatisfactory activity.
Xinhui Xu +5 more
doaj +1 more source
Intranuclear topological distribution of HIV‐1 trans‐activators [PDF]
FEBS Letters, 1992 Subcellular localization of human immunodeficiency virus type 1 (HIV‐1) Tat and Rev was examined using a confocal laser scanning microscope (CLSM). In transfected COS‐7 cells, Tat resided exclusively in the perinocleolar region, while Rev infiltrated fully into the nucleoli.
Miyazaki, Yukio +4 more
openaire +2 more sources
RNF12 activates Xist and is essential for X chromosome inactivation. [PDF]
PLoS Genetics, 2011 In somatic cells of female placental mammals, one of the two X chromosomes is transcriptionally silenced to accomplish an equal dose of X-encoded gene products in males and females.
Tahsin Stefan Barakat +9 more
doaj +1 more source
Synergy between HIV-1 Tat and adenovirus E1A is principally due to stabilization of transcriptional elongation [PDF]
, 1990 We studied the combined effects of Tat and general trans-activators, such as E1A and phorbol esters, on human immunodeficiency virus-1 (HIV-1) gene expression. Interaction between these two types of trans-activators may be involved in the transition from
Laspia, M. F. +2 more
core +1 more source
Signal Transduction and Targeted Therapy, 2023 Cancer cell receives extracellular signal inputs to obtain a stem-like status, yet how tumor microenvironmental (TME) neural signals steer cancer stemness to establish the hierarchical tumor architectures remains elusive.
Bin He +22 more
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