Results 11 to 20 of about 807,180 (300)
PLoS ONE, 2020 Chromatin structure plays a decisive role in gene regulation through the actions of transcriptional activators, coactivators, and epigenetic machinery.
Michelle Esposito +5 more
doaj +1 more source
Five hTRPA1 Agonists Found in Indigenous Korean Mint, Agastache rugosa. [PDF]
PLoS ONE, 2015 Transient receptor potential ankyrin1 (TRPA1) and transient receptor potential vanilloid 1 (TRPV1) are members of the TRP superfamily of structurally related, nonselective cation channels and mediators of several signaling pathways.
Hana Moon +8 more
doaj +1 more source
, 2023 This article engages with trans artistic practices: both trans in art as well as trans as art. It takes as its point of departure the artistic work of Ro Robertson, Tama Sharman, and Erica Rutherford, each of whom works with trans in different ways.
Hettinga, Lieks +2 more
core +1 more source
mRNA trans-splicing dual AAV vectors for (epi)genome editing and gene therapy
Nature Communications, 2023 Large genes including several CRISPR-Cas modules like gene activators (CRISPRa) require dual adeno-associated viral (AAV) vectors for an efficient in vivo delivery and expression.
Lisa Maria Riedmayr +20 more
doaj +1 more source
Programmable RNA detection with CRISPR-Cas12a
Nature Communications, 2023 Cas12a, a CRISPR-associated protein complex, has an inherent ability to cleave DNA substrates and is utilized in diagnostic tools to identify DNA molecules. We demonstrate that multiple orthologs of Cas12a activate trans-cleavage in the presence of split
Santosh R. Rananaware +8 more
doaj +1 more source
Structural basis of Janus kinase trans-activation
Cell Reports, 2023 Janus kinases (JAKs) mediate signal transduction downstream of cytokine receptors. Cytokine-dependent dimerization is conveyed across the cell membrane to drive JAK dimerization, trans-phosphorylation, and activation. Activated JAKs in turn phosphorylate receptor intracellular domains (ICDs), resulting in the recruitment, phosphorylation, and ...
Nathanael A. Caveney +6 more
openaire +3 more sources
, 2022 Typical microscopy videos of Fucoidan, MPO and LPS impact on granulocyte crawling among the growing thrombi.
Anastasia Sveshnikova (11941976)
core +1 more source
Gene activation by a CRISPR-assisted trans enhancer
eLife, 2019 The deactivated CRISPR/Cas9 (dCas9) is now the most widely used gene activator. However, current dCas9-based gene activators are still limited by their unsatisfactory activity.
Xinhui Xu +5 more
doaj +1 more source
RNF12 activates Xist and is essential for X chromosome inactivation. [PDF]
PLoS Genetics, 2011 In somatic cells of female placental mammals, one of the two X chromosomes is transcriptionally silenced to accomplish an equal dose of X-encoded gene products in males and females.
Tahsin Stefan Barakat +9 more
doaj +1 more source
Signal Transduction and Targeted Therapy, 2023 Cancer cell receives extracellular signal inputs to obtain a stem-like status, yet how tumor microenvironmental (TME) neural signals steer cancer stemness to establish the hierarchical tumor architectures remains elusive.
Bin He +22 more
doaj +1 more source