Results 1 to 10 of about 776,035 (216)

Set1 promotes Notch-induced transcriptional activation [PDF]

Cellular and Molecular Life Sciences
Notch is a highly conserved transmembrane receptor essential for organ development and homeostasis. Dysregulation of Notch signaling has been implicated in numerous human diseases. Upon ligand binding, the intracellular domain of Notch (NICD) is released
Huan Liu, Yuanyuan Zhang, Min Hou, Xiaojiao Li, Xiuxiu Liu, Yuanlin Su, Yu Song, Baichun Jiang, Molin Wang, Yongxin Zou, Qiao Liu, Yaoqin Gong, Gongping Sun   +12 more
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Bidirectional transcription directs both transcriptional gene activation and suppression in human cells. [PDF]

PLoS Genetics, 2008
Small RNAs targeted to gene promoters in human cells have been shown to modulate both transcriptional gene suppression and activation. However, the mechanism involved in transcriptional activation has remained poorly defined, and an endogenous RNA ...
Kevin V Morris, Sharon Santoso, Anne-Marie Turner, Chiara Pastori, Peter G Hawkins   +4 more
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Transcriptional Activation of Inflammatory Genes: Mechanistic Insight into Selectivity and Diversity

Biomolecules, 2015
Acute inflammation, an integral part of host defence and immunity, is a highly conserved cellular response to pathogens and other harmful stimuli. An inflammatory stimulation triggers transcriptional activation of selective pro-inflammatory genes that ...
Afsar U. Ahmed, Bryan R. G. Williams, Gregory E. Hannigan   +2 more
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Identification and Analysis of MYB Gene Family for Discovering Potential Regulators Responding to Abiotic Stresses in Curcuma wenyujin

Frontiers in Genetics, 2022
MYB superfamily is one of the most abundant families in plants, and plays critical role in plant growth, development, metabolism regulation, and stress response.
Qiuhui Wei, Qiuhui Wei, Yuyang Liu, Yuyang Liu, Kaer Lan, Kaer Lan, Xin Wei, Xin Wei, Tianyuan Hu, Tianyuan Hu, Rong Chen, Rong Chen, Shujuan Zhao, Shujuan Zhao, Xiaopu Yin, Xiaopu Yin, Tian Xie, Tian Xie   +17 more
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Interferon Regulatory Factors Functioned as Activators of the Interferon Pathway in the Scallop Chlamys farreri

Frontiers in Marine Science, 2022
Interferon regulatory factors (IRFs) are a family of transcription factors that control many facets during innate and adaptive immune responses. Vertebrate IRFs play important roles in regulating the expression of interferons (IFNs) and IFN-stimulated ...
Naina Hu, Shanshan Lian, Shanshan Lian, Xiaomei Zhu, Xiaomei Chen, Fengzhi Sun, Lingling Zhang, Lingling Zhang, Shi Wang, Shi Wang, Shi Wang, Zhenmin Bao, Zhenmin Bao, Zhenmin Bao, Jingjie Hu, Jingjie Hu   +15 more
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Epiprofin Transcriptional Activation Promotes Ameloblast Induction From Mouse Induced Pluripotent Stem Cells via the BMP-Smad Signaling Axis

Frontiers in Bioengineering and Biotechnology, 2022
The transcriptional regulation of induced pluripotent stem cells (iPSCs) holds promise for their directed differentiation into ameloblasts, which are usually lost after tooth eruption.
Xinchao Miao, Xinchao Miao, Kunimichi Niibe, Yunyu Fu, Maolin Zhang, Maolin Zhang, Praphawi Nattasit, Yumi Ohori-Morita, Takashi Nakamura, Xinquan Jiang, Hiroshi Egusa, Hiroshi Egusa   +11 more
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Generation of functional NaV1.5 current by endogenous transcriptional activation of SCN5A

Biotechnology & Biotechnological Equipment, 2021
The sodium channel NaV1.5, which is encoded by the SCN5A gene, underlies the fast upstroke of cardiac action potential and thus plays a crucial role in cardiac electrophysiology, but the mechanism governing the regulation of NaV1.5 has not been fully ...
Liang Xu, Rui Shi
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Transcriptome analysis provides StMYBA1 gene that regulates potato anthocyanin biosynthesis by activating structural genes

Frontiers in Plant Science, 2023
Anthocyanin biosynthesis is affected by light, temperature, and other environmental factors. The regulation mode of light on anthocyanin synthesis in apple, pear, tomato and other species has been reported, while not clear in potato.
Xijuan Zhao, Xijuan Zhao, Huiling Zhang, Tengfei Liu, Yanan Zhao, Xinxi Hu, Shengxuan Liu, Yuan Lin, Botao Song, Changzheng He   +9 more
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Ligand-induced shifts in conformational ensembles that describe transcriptional activation

eLife, 2022
Nuclear receptors function as ligand-regulated transcription factors whose ability to regulate diverse physiological processes is closely linked with conformational changes induced upon ligand binding.
Sabab Hasan Khan, Sean M Braet, Stephen John Koehler, Elizabeth Elacqua, Ganesh Srinivasan Anand, C Denise Okafor   +5 more
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Panax notoginseng WRKY Transcription Factor 9 Is a Positive Regulator in Responding to Root Rot Pathogen Fusarium solani

Frontiers in Plant Science, 2022
Panax notoginseng (Burk) F.H. Chen is a rare and valuable Chinese herb, but root rot mainly caused by Fusarium solani severely affects the yield and quality of P. notoginseng herbal materials. In this study, we isolated 30 P.
Lilei Zheng, Lilei Zheng, Bingling Qiu, Bingling Qiu, Linlin Su, Linlin Su, Hanlin Wang, Hanlin Wang, Xiuming Cui, Xiuming Cui, Feng Ge, Feng Ge, Diqiu Liu, Diqiu Liu   +13 more
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