Transcriptional program of osteoblast differentiation : coordinated activation of Notch, Wnt, and TGF-[beta] signaling pathways in MC3T3 cell line [PDF]
, 2005 In order to examine the early events in osteoblast differentiation, three different model systems for osteoblast differentiation were compared: mouse pre-osteoblastic cell line MC3T3; mouse myoblastic cell line C2C12 and primary mouse calvarial ...
Zamurovic, Natasa
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Long Non-Coding RNA Modulation of VEGF-A during Hypoxia
Non-Coding RNA, 2018 The role and function of long non-coding RNAs (lncRNAs) in modulating gene expression is becoming apparent. Vascular endothelial growth factor A (VEGF-A) is a key regulator of blood vessel formation and maintenance making it a promising therapeutic ...
Tiina Nieminen +5 more
doaj +1 more source
Bovine proteins containing poly-glutamine repeats are often polymorphic and enriched for components of transcriptional regulatory complexes [PDF]
, 2010 peer-reviewedBackground: About forty human diseases are caused by repeat instability mutations. A distinct subset of these diseases is the result of extreme expansions of polymorphic trinucleotide repeats; typically CAG repeats encoding poly-glutamine ...
Herman Raadsma +30 more
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The molecular dissection of the regulation of PGC-1α and the genome-wide activity of its transcriptional network in skeletal muscle cells [PDF]
, 2013 The transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) is a potent inducer of mitochondrial biogenesis and oxidative metabolism.
Barešić, Mario
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CadC-mediated activation of the cadBA promoter in Escherichia coli [PDF]
, 2005 The transcriptional activator CadC in Escherichia coli, a member of the ToxR-like proteins, activates transcription of the cadBA operon encoding the lysine decarboxylase CadA and the lysine-cadaverine antiporter CadB. cadBA is induced under conditions of
Kuper, C., Jung, K.
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Analysis of the transcriptional program of developing induced regulatory T cells. [PDF]
, 2011 CD25+ regulatory T cells develop in the thymus (nTregs), but may also be generated in the periphery upon stimulation of naive CD4 T cells under appropriate conditions (iTregs). To gain insight into the mechanisms governing iTreg development, we performed
Lipsky, Peter E. +8 more
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Structural basis of transcription activation [PDF]
Science, 2016 Transcription activation all about timing Regulating transcription by RNA polymerase (RNAP) is central to controlling gene expression. Transcription factors influence the activity of the RNAP. Feng et al. determined the crystal structure of a bacterial transcription activation complex.
Yu, Feng, Yu, Zhang, Richard H, Ebright
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Regulation of skeletal muscle plasticity by the transcriptional coregulators PGC-1α and NCoR1 [PDF]
, 2013 Skeletal muscle plasticity is regulated by a wide range of factors, among which environmental stimuli such as exercise play a central role. Importantly, changes in skeletal muscle phenotype exert a direct impact on health and risk to premature death.
Pérez-Schindler, Joaquín
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Frontiers in Molecular Biosciences, 2022 Human N-acetylgalactosamine-α2,6-sialyltransferase (hST6GalNAc I) is the major enzyme involved in the biosynthesis of sialyl-Tn antigen (sTn), which is known to be expressed in more than 80% of human carcinomas and correlated with poor prognosis in ...
So-Young An +5 more
doaj +1 more source
A conserved phosphorylation site regulates the transcriptional function of ETHYLENE-INSENSITIVE3-like1 in tomato [PDF]
, 2011 ETHYLENE-INSENSITIVE3/ETHYLENE-INSENSITIVE3-like (EIN3/EIL) transcription factors are important downstream components of the ethylene transduction pathway known to regulate the transcription of early ethylene-responsive genes in plants.
Z. Li +11 more
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