Results 61 to 70 of about 2,492,980 (260)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Targeted deficiency of the transcriptional activator Hnf1 alpha alters subnuclear positioning of its genomic targets [PDF]

, 2008
DNA binding transcriptional activators play a central role in gene-selective regulation. In part, this is mediated by targeting local covalent modifications of histone tails.
Luco, Reini F., Sadoni, Nicolas, Maestro, Miguel A., Miguel A Maestro, Luco Reini F., Ferrer Jorge, Zink Daniele, Daniele Zink, Sadoni Nicolas, Nicolas Sadoni, Jorge Ferrer, Maestro Miguel A., Ferrer, Jorge, Reini F Luco, Zink, Daniele   +14 more
core   +2 more sources

Neuronal Cell-type Engineering by Transcriptional Activation

Frontiers in Genome Editing, 2021
Gene activation with the CRISPR-Cas system has great implications in studying gene function, controlling cellular behavior, and modulating disease progression. In this review, we survey recent studies on targeted gene activation and multiplexed screening
Songlei Liu, Songlei Liu, Johannes Striebel, Giovanni Pasquini, Alex H. M. Ng, Parastoo Khoshakhlagh, George M. Church, George M. Church, George M. Church, Volker Busskamp   +9 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

p160/SRC/NCoA coactivators form complexes via specific interaction of their PAS-B domain with the CID/AD1 domain [PDF]

, 2008
Transcriptional activation involves the ordered recruitment of coactivators via direct interactions between distinct binding domains and recognition motifs.
Coudevylle, N., Pfitzner, E., Muenz, Tobias, Pfitzner, Edith, Becker, Stefan, Coudevylle, Nicolas, Münz, Tobias, Lodrini, M., Becker, S., Munz, T., Griesinger, C., Lodrini, Marco, Griesinger, Christian   +12 more
core   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Host Cell Reactivation and Transcriptional Activation of Carboplatin-Modified BRCA1

, 2014
The breast cancer susceptibility gene 1 ( BRCA1 ) has been shown to maintain genomic stability through multiple functions in the regulation of DNA damage repair and transcription.
Adisorn Ratanaphan, Bhutorn Canyuk
core   +1 more source

Establishment of CRISPR‐STAR System to Realise Simultaneous Transcriptional Activation and Repression in Yarrowia lipolytica

Microbial Biotechnology
The ability to regulate gene expression in multiple directions is crucial to maximise the production of microbial cell factories. However, the lack of a regulatory tool that can simultaneously activate and repress multiple genes restricts the ...
Yaru Chen, Mengxu Li, Xuanwei Liu, Qiyang Duan, Lin Xiao, Luxin Wang, Congcong Huang, Hao Song, Yingxiu Cao   +8 more
doaj   +1 more source

Longitudinal analysis of invariant natural killer T cell activation reveals a cMAF-associated transcriptional state of NKT10 cells

eLife, 2022
Innate T cells, including CD1d-restricted invariant natural killer T (iNKT) cells, are characterized by their rapid activation in response to non-peptide antigens, such as lipids. While the transcriptional profiles of naive, effector, and memory adaptive
Harry Kane, Nelson M LaMarche, Áine Ní Scannail, Amanda E Garza, Hui-Fern Koay, Adiba I Azad, Britta Kunkemoeller, Brenneth Stevens, Michael B Brenner, Lydia Lynch   +9 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source