Results 71 to 80 of about 797,090 (316)

GATA3 Regulates the Development and Functions of Innate Lymphoid Cell Subsets at Multiple Stages

Frontiers in Immunology, 2017
Innate lymphoid cells (ILCs) are regarded as the innate counterpart of effector CD4 T helper (Th) cells. Just as Th cells, ILCs are classified into distinct subsets based on their functions that are delivered mainly through effector cytokine production ...
Jinfang Zhu
doaj   +1 more source

The role of Nrf2 in astragaloside IV-mediated antioxidative protection on heart failure

Pharmaceutical Biology, 2020
Context Heart failure is one of the most serious diseases worldwide. Astragaloside IV (ASI) is widely used in the treatment of cardiovascular diseases.
Yan-Bo Sui, Kui-Kui Zhang, Yu-kun Ren, Li Liu, Yan Liu   +4 more
doaj   +1 more source

Transcriptional regulation: Kamikaze activators [PDF]

Current Biology, 2000
Transcription factors are often targeted for rapid degradation by the ubiquitin-proteasome system. Recent evidence points to a correlation between the potency and instability of transcriptional activators, suggesting a possible direct role for ubiquitin-dependent proteolysis in transcriptional activation.
Thomas, Dominique, Tyers, Mike
openaire   +2 more sources

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Targeted deficiency of the transcriptional activator Hnf1 alpha alters subnuclear positioning of its genomic targets [PDF]

, 2008
DNA binding transcriptional activators play a central role in gene-selective regulation. In part, this is mediated by targeting local covalent modifications of histone tails.
Luco, Reini F., Sadoni, Nicolas, Maestro, Miguel A., Miguel A Maestro, Luco Reini F., Ferrer Jorge, Zink Daniele, Daniele Zink, Sadoni Nicolas, Nicolas Sadoni, Jorge Ferrer, Maestro Miguel A., Ferrer, Jorge, Reini F Luco, Zink, Daniele   +14 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Identification of Egr1 as the oncostatin M-induced transcription activator that binds to sterol-independent regulatory element of human LDL receptor promoter

Journal of Lipid Research, 2002
Previously, we identified the low density lipoprotein receptor (LDLR) promoter region −17 to −1 as a novel sterol-independent regulatory element (SIRE) that mediates the stimulating effect of oncostatin M (OM).
Fang Zhang, Thomas E. Ahlborn, Cong Li, Fredric B. Kraemer, Jingwen Liu   +4 more
doaj   +1 more source

Neuronal Cell-type Engineering by Transcriptional Activation

Frontiers in Genome Editing, 2021
Gene activation with the CRISPR-Cas system has great implications in studying gene function, controlling cellular behavior, and modulating disease progression. In this review, we survey recent studies on targeted gene activation and multiplexed screening
Songlei Liu, Songlei Liu, Johannes Striebel, Giovanni Pasquini, Alex H. M. Ng, Parastoo Khoshakhlagh, George M. Church, George M. Church, George M. Church, Volker Busskamp   +9 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Stress-induced transcriptional activation [PDF]

Microbiological Reviews, 1995
Living cells, both prokaryotic and eukaryotic, employ specific sensory and signalling systems to obtain and transmit information from their environment in order to adjust cellular metabolism, growth, and development to environmental alterations. Among external factors that trigger such molecular communications are nutrients, ions, drugs and other ...
Mager, W.H., de Kruijff, A.J.J.
openaire   +3 more sources