Results 51 to 60 of about 797,090 (316)

Molecular and cellular mechanisms of adipogenesis

Сахарный диабет, 2015
The main components of metabolic syndrome include insulin resistance, hypertriglyceridemia and arterial hypertension. Obesity is the cause of metabolic syndrome, mainly as a consequence of the endocrine function of adipose tissue.
Alexander Dmitrievich Egorov, Dmitry Nikolaevich Penkov, Vsevolod Arsen'evich Tkachuk   +2 more
doaj   +1 more source

CRISPR/dCas9 Transcriptional Activation of Endogenous Apolipoprotein AI and Paraoxonase 1 in Enterocytes Alleviates Endothelial Cell Dysfunction

Biomolecules, 2021
Atherosclerosis is the main cause of cardiovascular diseases with high prevalence worldwide. A promising therapeutic strategy to reverse atherosclerotic process is to improve the athero-protective potential of high-density lipoproteins (HDL).
Laura Toma, Teodora Barbălată, Gabriela M. Sanda, Loredan S. Niculescu, Anca V. Sima, Camelia S. Stancu   +5 more
doaj   +1 more source

Stress-Induced PARP Activation Mediates Recruitment of Drosophila Mi-2 to Promote Heat Shock Gene Expression [PDF]

, 2011
Eukaryotic cells respond to genomic and environmental stresses, such as DNA damage and heat shock (HS), with the synthesis of poly-ADP-ribose] (PAR) at specific chromatin regions, such as DNA breaks or HS genes, by PAR polymerases (PARP). Little is known
Renate Renkawitz-Pohl, Hassler Markus, Murawska, Magdalena, Ladurner Andreas, Brehm Alexander, Andreas Ladurner, Renkawitz-Pohl, Renate, Brehm, Alexander, Ladurner, Andreas, Magdalena Murawska, Murawska Magdalena, Markus Hassler, Hassler, Markus, Alexander Brehm, Renkawitz-Pohl Renate   +14 more
core   +1 more source

Chromatin looping and eRNA transcription precede the transcriptional activation of gene in the β-globin locus

Bioscience Reports, 2015
Enhancers are closely positioned with actively transcribed target genes by chromatin looping. Non-coding RNAs are often transcribed on active enhancers, referred to as eRNAs (enhancer RNAs).
Yea Woon Kim, Sungkung Lee, Jangmi Yun, AeRi Kim   +3 more
doaj   +1 more source

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source

The structure of CrgA from Neisseria meningitidis reveals a new octameric assembly state for LysR transcriptional regulators [PDF]

, 2009
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/ by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in ...
Gilbert, RJ, Saunders, Nigel, Saunders, NJ, Sainsbury, Sarah, Saunders, Nigel J., Owens, Raymond, Sainsbury, S, Owens, RJ, Ren, J, Lane, Laura A., Ren, Jingshan, Stuart, David I., Robinson, CV, Robinson, Carol V., Owens, Raymond J., Gilbert, Robert J., Lane, LA, Gilbert, Robert, Stuart, DI, Stuart, David   +19 more
core   +2 more sources

Spontaneous virus reactivation in cattle chronically infected with bovine leukemia virus

BMC Veterinary Research, 2019
Background The absence of virus expression during the chronic stage of bovine leukemia virus (BLV) infection and its reactivation upon ex vivo culture has become a long-lived Dogma.
Juan Pablo Jaworski, Marcos Iván Petersen, Hugo Adrián Carignano, Karina Gabriela Trono   +3 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Manipulation of the Plant Host by the Geminivirus AC2/C2 Protein, a Central Player in the Infection Cycle

Frontiers in Plant Science, 2020
Geminiviruses are a significant group of emergent plant DNA viruses causing devastating diseases in food crops worldwide, including the Southern United States, Central America and the Caribbean.
Jennifer Guerrero, Elizabeth Regedanz, Liu Lu, Jianhua Ruan, David M. Bisaro, Garry Sunter   +5 more
doaj   +1 more source

A Shortcut to Activity-Dependent Transcription [PDF]

Cell, 2015
Neuronal activity results in the rapid induction of gene transcription through a series of defined molecular events. Madabhushi et al. describe an unexpected role for the cutting of promoter DNA by topoisomerase IIB to facilitate transcription of activity-induced genes.
Sharma, Nikhil, Gabel, Harrison W., Greenberg, Michael E.   +2 more
openaire   +2 more sources