Results 31 to 40 of about 797,090 (316)
Cathepsins as Transcriptional Activators? [PDF]
Developmental Cell, 2004 One action of proteases is limited cleavage of latent transcription factors, releasing active factors to initiate nuclear signaling. Goulet et al., in a recent Molecular Cell paper, provide evidence that a lysosomal protease, cathepsin L, exists in a previously unsuspected isoform capable of trafficking to the nucleus and activating the CDP/Cux ...
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Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1α : modulation by p38 MAPK [PDF]
, 2004 The transcriptional coactivator PPAR gamma coactivator 1 α (PGC-1α) is a key regulator of metabolic processes such as mitochondrial biogenesis and respiration in muscle and gluconeogenesis in liver. Reduced levels of PGC-1α in humans have been associated
Lin, J. +9 more
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Frontiers in Plant Science, 2021 Secondary wall-associated NAC (SWN) genes are a subgroup of NAC (NAM, ATAF, and CUC) transcription factors (TF) that play a key role in regulating secondary cell wall biosynthesis in plants.
Na Xu +7 more
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Recording transcriptional activity [PDF]
Nature Methods, 2018 Acquisition of RNA into CRISPR arrays allows the recording of transcriptional dynamics in cells.
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Co‐activator activator (CoAA) prevents the transcriptional activity of Runt domain transcription factors [PDF]
Journal of Cellular Biochemistry, 2009 AbstractRunx proteins are essential for a number of developmental processes and are aberrantly expressed in many human cancers. Runx factors bind DNA and co‐factors to activate or repress genes crucial for bone formation, hematopoiesis, and neuronal development.
Xiaodong, Li +4 more
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Host Cell Reactivation and Transcriptional Activation of Carboplatin-Modified BRCA1 [PDF]
, 2014 The breast cancer susceptibility gene 1 ( BRCA1 ) has been shown to maintain genomic stability through multiple functions in the regulation of DNA damage repair and transcription.
Adisorn Ratanaphan, Bhutorn Canyuk
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Cell-specific activity of the modulator region in the human cytomegalovirus major immediate-early gene [PDF]
, 1989 In this paper we demonstrate that modulator sequences upstream of the enhancer of the major immediate-early promoter of human cytomegalovirus exert a differential effect on the level of transcription in a variety of cells and that this region has the ...
Lubon, H +6 more
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The Two Sides of YY1 in Cancer: A Friend and a Foe
Frontiers in Oncology, 2019 Yin Yang 1 (YY1), a dual function transcription factor, is known to regulate transcriptional activation and repression of many genes associated with multiple cellular processes including cellular differentiation, DNA repair, autophagy, cell survival vs ...
Sailu Sarvagalla +2 more
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A mutant cell line partially responsive to both IFN-a and IFN-g [PDF]
Brazilian Journal of Medical and Biological Research, 1997 A recessive mutant cell line, B7, which is partially responsive to both interferon (IFN)- a and IFN-g is described. B7 was FACS sorted from a cellular pool, which was obtained from the parental cell line 2C4, after several rounds of mutagenesis.
C.A. Bonjardim
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Transcriptional activation: Is it rocket science? [PDF]
Proceedings of the National Academy of Sciences, 1997 One of the beautiful things about biology is that you don’t have to fully understand it to put it to good use. The engineers who design spacecraft may need a certain working familiarity with all of the parts in their systems. But biologists, and particularly biologists whose mission is to treat human disease, can make do with considerably more ...
R, Pollock, M, Gilman
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