Results 11 to 20 of about 2,492,980 (260)

CRISPR-Based Approaches for Gene Regulation in Non-Model Bacteria

Frontiers in Genome Editing, 2022
CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa) have become ubiquitous approaches to control gene expression in bacteria due to their simple design and effectiveness.
Stephanie N. Call, Lauren B. Andrews, Lauren B. Andrews, Lauren B. Andrews   +3 more
doaj   +1 more source

Role of estrogen receptor coregulators in endocrine resistant breast cancer

Exploration of Targeted Anti-tumor Therapy, 2021
Breast cancer (BC) is the most ubiquitous cancer in women. Approximately 70–80% of BC diagnoses are positive for estrogen receptor (ER) alpha (ERα).
Kristin A. Altwegg, Ratna K. Vadlamudi
doaj   +1 more source

Genome-wide profiling of transcribed enhancers during macrophage activation

Epigenetics & Chromatin, 2017
Background Macrophages are sentinel cells essential for tissue homeostasis and host defence. Owing to their plasticity, macrophages acquire a range of functional phenotypes in response to microenvironmental stimuli, of which M(IFN-γ) and M(IL-4/IL-13 ...
Elena Denisenko, Reto Guler, Musa M. Mhlanga, Harukazu Suzuki, Frank Brombacher, Sebastian Schmeier   +5 more
doaj   +1 more source

Duck Plague Virus pUL48 Protein Activates the Immediate-Early Gene to Initiate the Transcription of the Virus Gene

Frontiers in Microbiology, 2021
Duck plague caused by the duck plague virus (DPV) is an infectious disease that seriously harms the waterfowl breeding industry. The VP16 protein of α herpesvirus can bind to specific cis-acting elements upstream of the promoter of the immediate-early ...
Tong Zhou, Tong Zhou, Tong Zhou, Dengjian Fan, Dengjian Fan, Dengjian Fan, Mingshu Wang, Mingshu Wang, Mingshu Wang, Anchun Cheng, Anchun Cheng, Anchun Cheng, Ying Wu, Ying Wu, Ying Wu, Qiao Yang, Qiao Yang, Qiao Yang, Bin Tian, Bin Tian, Bin Tian, Renyong Jia, Renyong Jia, Renyong Jia, Xumin Ou, Xumin Ou, Xumin Ou, Sai Mao, Sai Mao, Sai Mao, Di Sun, Di Sun, Di Sun, Shaqiu Zhang, Shaqiu Zhang, Shaqiu Zhang, Dekang Zhu, Dekang Zhu, Shun Chen, Shun Chen, Shun Chen, Mafeng Liu, Mafeng Liu, Mafeng Liu, Xin-Xin Zhao, Xin-Xin Zhao, Xin-Xin Zhao, Juan Huang, Juan Huang, Juan Huang, Qun Gao, Qun Gao, Qun Gao, Yanling Yu, Yanling Yu, Yanling Yu, Ling Zhang, Ling Zhang, Ling Zhang   +58 more
doaj   +1 more source

PIM1-dependent phosphorylation of Histone H3 at Serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation. [PDF]

, 2007
The serine/threonine kinase PIM1, cooperates with MYC in cell cycle progression and tumorigenesis. However, the nature of this cooperation remains elusive.
Salvatore Oliviero, Serafini, Riccardo, Riccardo Serafini, Alessandra De Robertis, Alessio Zippo, De Robertis, Alessandra, Zippo, Alessio, Oliviero, Salvatore   +7 more
core   +1 more source

Malignancy-Associated Regions of Transcriptional Activation: Gene Expression Profiling Identifies Common Chromosomal Regions of a Recurrent Transcriptional Activation in Human Prostate, Breast, Ovarian, and Colon Cancers

Neoplasia: An International Journal for Oncology Research, 2003
Despite remarkable advances in our understanding of a genetic basis of cancer, the precise molecular definition of the phenotypically relevant genetic features associated with human epithelial malignancies remains a significant and highly relevant ...
Gennadi V. Glinsky, Anja Krones-Herzig, Anna B. Glinskii   +2 more
doaj   +1 more source

Transcriptional regulation of the human ALDH1A1 promoter by the oncogenic homeoprotein TLX1/HOX11 [PDF]

, 2009
The homeoprotein TLX1, which is essential to spleen organogenesis and oncogenic when aberrantly expressed in immature T cells, functions as a bifunctional transcriptional regulator, being capable of activation or repression depending on cell type and/or ...
Heidari, M., Taplin, R., Wayne Kenneth Greene, Kees, U.R., Ross Taplin, Kim Rice, Greene, W.K., Ursula Kees, Wayne Greene, Rice, K.L., Mansour Heidari   +10 more
core   +1 more source

Role of SUMO-1 modification in transcriptional activation [PDF]

, 2012
In unstimulated cells, the transcription factor NF-κB is held in the cytoplasm in an inactive state by IκB inhibitor proteins. Activation of NF--KB is mediated by signal induced degradation of IκBα via the ubiquitin proteasome-dependent pathway ...
Pinto Desterro, Maria Joana
core   +2 more sources

Human papillomavirus 16 L2 inhibits the transcriptional activation function, but not the DNA replication function, of HPV-16 E2 [PDF]

, 2005
In this study we analysed the outcome of the interaction between HPV-16 L2 and E2 on the transactivation and DNA replication functions of E2. When E2 was expressed on its own, it transactivated a number of E2-responsive promoters but co-expression of L2 ...
Morgan, I.M., Cordano, P., Taylor, E.R., Everett, R., R. Everett, A. Okoye, M.S. Campo, P. Cordano, E.R. Taylor, Campo, M.S., I.M. Morgan, Okoye, A.   +11 more
core   +1 more source

Dengue virus infection induces chromatin remodeling at locus AAEL006536 in the midgut of Aedes aegypti

Salud Pública de México, 2017
Objective. To identify and characterize Aedes aegypti’s AAEL006536 gene proximal upstream cis-regulatory sequences activated by dengue virus infection. Materials and methods. A. aegypti Rockefeller strain mosquitoes were blood fed or infected with dengue
Graciela Gleason-Rodríguez, Manuel Castillo-Méndez, Krystal Maya, José Ramos-Castañeda, Verónica Valverde-Garduño   +4 more
doaj   +1 more source