Results 11 to 20 of about 797,090 (316)
DNA intervention in transcriptional activation [PDF]
FEBS Letters, 1992 Accurate initiation of eukaryotic mRNA synthesis takes place as a result of the interplay between general transcription factors and RNA polymerase II. Activation of transcription from the basal level involves a number of promoter‐specific trans‐acting factors which interact with cis elements in the promoter DNA.
Bhargava, Purnima, Chatterji, Dipankar
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Ligand-induced shifts in conformational ensembles that describe transcriptional activation
eLife, 2022 Nuclear receptors function as ligand-regulated transcription factors whose ability to regulate diverse physiological processes is closely linked with conformational changes induced upon ligand binding.
Sabab Hasan Khan +5 more
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Frontiers in Plant Science, 2022 Panax notoginseng (Burk) F.H. Chen is a rare and valuable Chinese herb, but root rot mainly caused by Fusarium solani severely affects the yield and quality of P. notoginseng herbal materials. In this study, we isolated 30 P.
Lilei Zheng +13 more
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CRISPR-Based Approaches for Gene Regulation in Non-Model Bacteria
Frontiers in Genome Editing, 2022 CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa) have become ubiquitous approaches to control gene expression in bacteria due to their simple design and effectiveness.
Stephanie N. Call +3 more
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Transcriptional Activation: Tuning-up transcription [PDF]
Current Biology, 1995 Eukaryotic transcription is a complex process, and recent results identify multiple steps that need to be stimulated to activate transcription, one of which is a change in conformation of the general transcription factor TFIIB.
Sheldon, Michael, Danny, Reinberg
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Role of estrogen receptor coregulators in endocrine resistant breast cancer
Exploration of Targeted Anti-tumor Therapy, 2021 Breast cancer (BC) is the most ubiquitous cancer in women. Approximately 70–80% of BC diagnoses are positive for estrogen receptor (ER) alpha (ERα).
Kristin A. Altwegg, Ratna K. Vadlamudi
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Genome-wide profiling of transcribed enhancers during macrophage activation
Epigenetics & Chromatin, 2017 Background Macrophages are sentinel cells essential for tissue homeostasis and host defence. Owing to their plasticity, macrophages acquire a range of functional phenotypes in response to microenvironmental stimuli, of which M(IFN-γ) and M(IL-4/IL-13 ...
Elena Denisenko +5 more
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Transcriptional activators and activation mechanisms [PDF]
Protein & Cell, 2007 Transcriptional activators are required to turn on the expression of genes in a eukaryotic cell. Activators bound to the enhancer can facilitate either the recruitment of RNA polymerase II to the promoter or its elongation. This article examines a few selected issues in understanding activator functions and activation mechanisms.
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PIM1-dependent phosphorylation of Histone H3 at Serine 10 is required for MYC-dependent transcriptional activation and oncogenic transformation. [PDF]
, 2007 The serine/threonine kinase PIM1, cooperates with MYC in cell cycle progression and tumorigenesis. However, the nature of this cooperation remains elusive.
Salvatore Oliviero +7 more
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Transcriptional regulation of the human ALDH1A1 promoter by the oncogenic homeoprotein TLX1/HOX11 [PDF]
, 2009 The homeoprotein TLX1, which is essential to spleen organogenesis and oncogenic when aberrantly expressed in immature T cells, functions as a bifunctional transcriptional regulator, being capable of activation or repression depending on cell type and/or ...
Heidari, M. +10 more
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