Results 1 to 10 of about 4,748,947 (305)

Genetic recombination is targeted towards gene promoter regions in dogs. [PDF]

PLoS Genetics, 2013
The identification of the H3K4 trimethylase, PRDM9, as the gene responsible for recombination hotspot localization has provided considerable insight into the mechanisms by which recombination is initiated in mammals.
Adam Auton, Ying Rui Li, Jeffrey Kidd, Kyle Oliveira, Julie Nadel, J Kim Holloway, Jessica J Hayward, Paula E Cohen, John M Greally, Jun Wang, Jun Wang, Carlos D Bustamante, Adam R Boyko   +12 more
doaj   +8 more sources

Anticoagulant protein C p.Lys193del mutation and promoter region polymorphisms: Genetic risk factors of deep venous thrombosis

LabMed Discovery
Objective: Deep venous thrombosis (DVT), a potentially life-threatening condition with a high clinical incidence, represents a significant healthcare burden in China.
Xu-qian Wei, Xiao-lei Yi, Wei-bin Chen, Jin Tang, Jing Dai   +4 more
doaj   +3 more sources

Building the Frequency Profile of the Core Promoter Element Patterns in the Three ChromHMM Promoter States at 200bp Intervals: A Statistical Perspective [PDF]

Genomics & Informatics, 2015
Recently, the Encyclopedia of DNA Elements (ENCODE) Analysis Working Group converted data from ChIP-seq analyses from the Broad Histone track into 15 corresponding chromatic maps that label sequences with different kinds of histone modifications in ...
Heather Lent, Kyung-Eun Lee, Hyun-Seok Park   +2 more
doaj   +1 more source

In silico analysis of promoter region and regulatory elements of glucan endo-1,3-beta-glucosidase encoding genes in Solanum tuberosum: cultivar DM 1-3 516 R44

Journal of Genetic Engineering and Biotechnology, 2021
Background Potato (Solanum tuberosum L.) is one of the most important food crops in the world. Pathogens remain as one of the major constraints limiting potato productivity.
Atnafu Kebede, Mulugeta Kebede
doaj   +1 more source

DNA structural and physical properties reveal peculiarities in promoter sequences of the bacterium Escherichia coli K-12

SN Applied Sciences, 2021
The gene transcription of bacteria starts with a promoter sequence being recognized by a transcription factor found in the RNAP enzyme, this process is assisted through the conservation of nucleotides as well as other factors governing these intergenic ...
Gustavo Sganzerla Martinez, Scheila de Ávila e Silva, Aditya Kumar, Ernesto Pérez-Rueda   +3 more
doaj   +1 more source

Insights into alpha-hemolysin (Hla) evolution and expression among Staphylococcus aureus clones with hospital and community origin. [PDF]

PLoS ONE, 2014
Alpha-hemolysin (Hla) is a major virulence factor in the pathogenesis of Staphylococcus aureus infection, being active against a wide range of host cells. Although hla is ubiquitous in S.
Ana Tavares, Jesper B Nielsen, Kit Boye, Susanne Rohde, Ana C Paulo, Henrik Westh, Kristian Schønning, Hermínia de Lencastre, Maria Miragaia   +8 more
doaj   +1 more source

Genetic variants in histone modification regions are associated with the prognosis of lung adenocarcinoma

Scientific Reports, 2021
We investigated the association between genetic variants in the histone modification regions and the prognosis of lung adenocarcinoma after curative surgery. Potentially functional SNPs were selected using integrated analysis of ChIP-seq and RNA-seq. The
Hyo-Gyoung Kang, Yong Hoon Lee, Shin Yup Lee, Jin Eun Choi, Sook Kyung Do, Mi Jeong Hong, Jang Hyuck Lee, Ji Yun Jeong, Young Woo Do, Eung Bae Lee, Kyung Min Shin, Won Kee Lee, Sun Ha Choi, Hye won Seo, Seung Soo Yoo, Jaehee Lee, Seung Ick Cha, Chang Ho Kim, Sukki Cho, Sanghoon Jheon, Jae Yong Park   +20 more
doaj   +1 more source

Isolation of novel citrus and plum fruit promoters and their functional characterization for fruit biotechnology

BMC Biotechnology, 2020
Background Promoters that confer expression in fruit tissues are important tools for genetic engineering of fruit quality traits, yet few fruit-specific promoters have been identified, particularly for citrus fruit development.
Kasturi Dasgupta, Sara Hotton, William Belknap, Yasra Syed, Christopher Dardick, Roger Thilmony, James G. Thomson   +6 more
doaj   +1 more source

Characterization of transcriptional enhancers in the chicken genome using CRISPR-mediated activation

Frontiers in Genome Editing, 2023
DNA regulatory elements intricately control when, where, and how genes are activated. Therefore, understanding the function of these elements could unveil the complexity of the genetic regulation network.
Jeong Hoon Han, Hong Jo Lee, Tae Hyun Kim, Tae Hyun Kim   +3 more
doaj   +1 more source

Genetic and Epigenetic Alterations of CDH1 Regulatory Regions in Hereditary and Sporadic Gastric Cancer

Pharmaceuticals, 2021
E-cadherin is a key player in gastric cancer (GC) and germline alterations of CDH1, its encoding gene, are responsible for Hereditary Diffuse Gastric Cancer (HDGC) syndrome. This study aimed at elucidating the role of genetic variants and DNA methylation
Gianluca Tedaldi, Chiara Molinari, Celina São José, Rita Barbosa-Matos, Ana André, Rita Danesi, Valentina Arcangeli, Mila Ravegnani, Luca Saragoni, Paolo Morgagni, Francesca Rebuzzi, Matteo Canale, Sara Pignatta, Elisa Ferracci, Giovanni Martinelli, Guglielmina Nadia Ranzani, Carla Oliveira, Daniele Calistri, Paola Ulivi   +18 more
doaj   +1 more source