Results 31 to 40 of about 4,748,947 (305)

Interaction between non-coding RNAs, mRNAs and G-quadruplexes

open access: yesCancer Cell International, 2022
G-quadruplexes are secondary helical configurations established between guanine-rich nucleic acids. The structure is seen in the promoter regions of numerous genes under certain situations.
Soudeh Ghafouri-Fard   +6 more
doaj   +1 more source

O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation [PDF]

open access: yes, 2011
Background: We analyzed prospectively whether MGMT (O(6)-methylguanine-DNA methyltransferase) mRNA expression gains prognostic/predictive impact independent of MGMT promoter methylation in malignant glioma patients undergoing radiotherapy with ...
Kreth Simone   +35 more
core   +1 more source

Genetic Polymorphism of the Nrf2 Promoter Region (rs35652124) Is Associated with the Risk of Diabetic Foot Ulcers [PDF]

open access: yesOxidative Medicine and Cellular Longevity, 2020
The genetic polymorphism in the nuclear factor erythroid 2-related factor 2 (Nrf2) gene has been reported as one of the prognosis markers for various diseases, including cancer. Nrf2 is a key transcription factor involved in wound healing by regulating angiogenesis.
Rajan Teena   +4 more
openaire   +2 more sources

Comparative analysis on the structural features of the 5' flanking region of kappa-casein genes from six different species [PDF]

open access: yes, 2002
Kappa-casein plays an essential role in the formation, stabilisation and aggregation of milk micelles. Control of kappa-casein expression reflects this essential role, although an understanding of the mechanisms involved lags behind that of the other ...
C. Bruce A. Whitelaw,   +16 more
core   +1 more source

Construction and characterization of a synthetic Baculovirus-inducible 39K promoter

open access: yesJournal of Biological Engineering, 2018
Background Silkworm genetic engineering is widely used in gene function, silk engineering and disease-resistant engineering in most of Asia. Some of the earliest promoter elements are used to control the development of silkworm transgenic expression and ...
Zhan-Qi Dong   +7 more
doaj   +1 more source

Genetic Alteration of p16INKA4A Promoter Region in Endometrial Carcinoma

open access: yesKorean Journal of Gynecologic Oncology, 2005
Objective : This study was performed to evaluate the status of p16 tumor suppressor gene in 25 endometrial carcinomas (ECs) and to correlate the loss of heterozygosity (LOH) at p16 locus, the presence of inactivating mutations, the methylation status of the promotor, and the expression of p16 protein with clinicopathological parameters.
Se Jin Kim   +7 more
openaire   +1 more source

New insights into the novel and functional promoter sequences of β-1,3-glucanase gene from Hevea brasiliensis

open access: yesJournal of Plant Protection Research, 2021
β-1,3-glucanases play a major role in combating the abnormal leaf fall disease (ALF) caused by the oomycete Phytophthora spp. in Hevea brasiliensis, the major commercial source of natural rubber. In this study, partial sequences of four novel promoters
Supriya Radhakrishnan   +3 more
doaj   +1 more source

Escherichia coli σ70 senses sequence and conformation of the promoter spacer region [PDF]

open access: yes, 2010
In bacteria, promoter identification by RNA polymerase is mediated by a dissociable p factor. The housekeeping σ70 factor of Escherichia coli recognizes two well characterized DNA sequence elements, known as the ‘-10’ and ‘-35’ hexamers.
Shivani S. Singh   +11 more
core   +1 more source

Response to combination therapy with interferon alfa-2a and ribavirin in chronic hepatitis C according to a TNF-alpha promoter polymorphism [PDF]

open access: yes, 2003
Background. Tumor necrosis factor-alpha (TNF-alpha) is involved in the pathogenesis of chronic active hepatitis C. Polymorphisms in the promoter region of the TNF-alpha gene can alter the TNF-alpha expression and modify the host immune response.
Konig, A.   +8 more
core   +1 more source

Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression [PDF]

open access: yes, 2013
Associations between single nucleotide polymorphisms (SNPs) at 5p15 and multiple cancer types have been reported. We have previously shown evidence for a strong association between prostate cancer (PrCa) risk and rs2242652 at 5p15, intronic in the ...
Hayes, R B   +361 more
core   +2 more sources

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