Results 51 to 60 of about 4,748,947 (305)

Molecular characterization of the giant freshwater prawn (Macrobrachium rosenbergii) beta-actin gene promoter [PDF]

PeerJ, 2018
Constitutive promoters are important tools for gene function studies and transgenesis. The Beta-actin (actb1) gene promoter has been isolated from many species but remains to be cloned from the giant freshwater prawn (Macrobrachium rosenbergii).
Junjun Yan, Qiang Gao, Zongbin Cui, Guoliang Yang, Yong Long   +4 more
doaj   +2 more sources

Transcriptional regulation of the human ALDH1A1 promoter by the oncogenic homeoprotein TLX1/HOX11 [PDF]

, 2009
The homeoprotein TLX1, which is essential to spleen organogenesis and oncogenic when aberrantly expressed in immature T cells, functions as a bifunctional transcriptional regulator, being capable of activation or repression depending on cell type and/or ...
Heidari, M., Taplin, R., Wayne Kenneth Greene, Kees, U.R., Ross Taplin, Kim Rice, Greene, W.K., Ursula Kees, Wayne Greene, Rice, K.L., Mansour Heidari   +10 more
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Tissue of origin determines cancer-associated CpG island promoter hypermethylation patterns [PDF]

, 2012
: BACKGROUND: Aberrant CpG island promoter DNA hypermethylation is frequently observed in cancer and is believed to contribute to tumor progression by silencing the expression of tumor suppressor genes.
Sproul, Duncan, J Michael Dixon, Nestor, Colm E,, Ramsahoye, Bernard H, Nestor, Colm E, Sims, Andrew H, Harrison, David J, Meehan, Richard R,, Sims, Andrew H,, Dixon, J Michael,, David J Harrison, Ramsahoye, Bernard H,, Kitchen, Robert R, Sproul, Duncan,, Meehan, Richard R, Richard R Meehan, Dixon, J Michael, Andrew H Sims, Bernard H Ramsahoye, Robert R Kitchen, Duncan Sproul, Harrison, David J,, Colm E Nestor, Kitchen, Robert R,   +23 more
core   +1 more source

Integrative genomic analyses of promoter G-quadruplexes reveal their selective constraint and association with gene activation

Communications Biology, 2023
G-quadruplexes (G4s) regulate DNA replication and gene transcription, and are enriched in promoters without fully appreciated functional relevance.
Guangyue Li, Gongbo Su, Yunxuan Wang, Wenmeng Wang, Jinming Shi, Dangdang Li, Guangchao Sui   +6 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Functional mapping of pea legumin upstream regulatory elements using TI plasmid vectors [PDF]

, 1991
The leg A gene from Pisum sativum L. has been extensively characterised and a distinct pattern of developmental and organ-specific gene expression demonstrated.
Garrett, Christine, Garrett, C
core  

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

DNA methylation analysis of the angiotensin converting enzyme (ACE) gene in major depression. [PDF]

, 2012
The angiotensin converting enzyme (ACE) has been repeatedly discussed as susceptibility factor for major depression (MD) and the bi-directional relation between MD and cardiovascular disorders (CVD).
Eisenmenger, Wolfgang, Bondy, Brigitta, Mazza, Marianna, Zill, Peter, Clemens Früstück, Brigitta Bondy, Büttner, Andreas, Born, Christoph, Peter Zill, Andreas Büttner, Varallo-Bedarida, Gabriella, Cornelius Schüle, Früstück, Clemens, Rupprecht, Rainer, Möller, Hans-Jürgen, Schüle, Cornelius, Baghai, Thomas C., Wolfgang Eisenmenger, Christoph Born, Rainer Rupprecht, Hans-Jürgen Möller, Thomas C Baghai, Gabriella Varallo-Bedarida   +22 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source