Results 61 to 70 of about 390,492 (308)

Genetic polymorphism of the Nrf2 promoter region is associated with vitiligo risk in Han Chinese populations [PDF]

Journal of Cellular and Molecular Medicine, 2016
Abstract The nuclear factor erythroid‐derived two‐like 2‐antioxidant response element (Nrf2‐ ARE ) pathway and its downstream antioxidant enzyme heme oxygenase‐1 ( HMOX 1 or HO ‐1) play essential
Song, Pu, Li, Kai, Liu, Ling, Wang, Xiaowen, Jian, Zhe, Zhang, Weigang, Wang, Gang, Li, Chunying, Gao, Tianwen   +8 more
openaire   +2 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Host genetic factors in hepatitis B infection, liver cancer and vaccination response: a review with a focus on Africa. [PDF]

, 2012
The disease burden due to hepatitis B virus (HBV) infection remains significant; 350 million people are infected world-wide, and around half a million deaths each year are due to HBV-related liver disease and hepatocellular carcinoma (HCC).
Hall, Andrew J, Andrew J. Hall, Branwen J. Hennig, Hennig, Branwen J   +3 more
core   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Long-range evolutionary constraints reveal cis-regulatory interactions on the human X chromosome. [PDF]

, 2014
Enhancers can regulate the transcription of genes over long genomic distances. This is thought to lead to selection against genomic rearrangements within such regions that may disrupt this functional linkage.
Rinkwitz, S, Bally-Cuif, Laure, Chilamakuri, Chandra S R, Wilson, David I., Ishibashi, M, Rinkwitz, Silke, Wilson, SW, Crollius, H. R., Hawkins, Thomas A., FitzPatrick, David R, Becker, Thomas S, Wilson, Stephen W., Strähle, U., Becker, TS, Rastegar, S., Lenhard, B., Hawkins, TA, Raymond, F. L., Chilamakuri, CS, Hawkins, T. A., Louis, A., Louis, A, Louis, Alexandra, Wilson, D. I., Chilamakuri, Chandra S. R., Hawkins, Thomas A, Ishibashi, Minaka, Crollius, Hugues Roest, Naville, M., Strähle, U, Wilson, S. W., Rastegar, Sepand, Lenhard, Boris, Becker, Thomas S., Straehle, Uwe, Manning, E, Bally-Cuif, L., FitzPatrick, David R., Bengani, H, Manning, E., Rastegar, S, Ferg, M, Roest Crollius, Hugues, Heyningen, V. van, Roest Crollius, H, Ferg, Marco, Bengani, Hemant, Lucy Raymond, F., Lucy Raymond, F, Naville, Magali, Krecsmarik, Monika, FitzPatrick, D. R., Bengani, H., Chilamakuri, C. S. R., Wilson, Stephen W, Ishibashi, M., Naville, M, Wilson, David I, van Heyningen, V, Bally-Cuif, L, Wilson, DI, Rinkwitz, S., Strähle, Uwe, Chilamakuri, Chandra Sekhar Reddy, FitzPatrick, DR, Raymond, F. Lucy, Ferg, M., Krecsmarik, M, Becker, T. S., van Heyningen, Veronica, Lenhard, B, Manning, Elizabeth, Krecsmarik, M.   +72 more
core   +1 more source

Genetic Variation in the Promoter Region of Chitinase 3-Like 1 Is Associated with Atopy

American Journal of Respiratory and Critical Care Medicine, 2009
Abstract Rationale Atopy or atopic syndrome is an allergic hypersensitivity subject to hereditary influences. Aberrant expression of chitinase 3-like 1 (CHI3L1), also known as YKL-40 or HC gp-39, is involved in the pathogenesis of inflammatory and allergic diseases.
Myung Hyun, Sohn, Ji Hyun, Lee, Kyung Won, Kim, So Won, Kim, Sung Hee, Lee, Kyu-Earn, Kim, Kyung Hwan, Kim, Chun Geun, Lee, Jack A, Elias, Min Goo, Lee   +9 more
openaire   +3 more sources

Five novel cis-regulatory deletions of SOX10 cause Waardenburg syndrome type II

Frontiers in Audiology and Otology
IntroductionWaardenburg syndrome (WS) is a genetic disorder characterized by hearing loss, hypopigmentation, and distinct facial features. Despite > 60% molecular diagnosis rate for WS patients, pathogenic variants within coding regions are ...
Yu Huang, Yu Huang, Jia Geng, Jia Geng, Yang Long, Wenyu Xiong, Wenyu Xiong, Lu Kang, Lu Kang, Meilin Chen, Meilin Chen, Ting Tang, Ting Tang, Mingjun Zhong, Mingjun Zhong, Fengxiao Bu, Fengxiao Bu, Yu Lu, Yu Lu, Jing Cheng, Jing Cheng, Huijun Yuan, Huijun Yuan   +22 more
doaj   +1 more source

Promoter analysis of macrophage- and tick cell-specific differentially expressed Ehrlichia chaffeensis p28-Omp genes

BMC Microbiology, 2009
Background Ehrlichia chaffeensis is a rickettsial agent responsible for an emerging tick-borne illness, human monocytic ehrlichiosis. Recently, we reported that E. chaffeensis protein expression is influenced by macrophage and tick cell environments.
Ganta Roman R, Cheng Chuanmin, Peddireddi Lalitha   +2 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Mechanism of chromatin reassembly at the yeast PHO5 promoter upon repression [PDF]

, 2007
The goal of this study has been to elucidate the mechanisms responsible for rebuilding nucleosomes at the PHO5 promoter upon rerepression. In this work, I could unambiguously show that histones are incorporated at the PHO5 promoter upon repression ...
Schermer, Ulrike
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