Functional Characterization of Genetic Polymorphisms Identified in the Promoter Region of the Bovine PEPS Gene [PDF]
DNA and Cell Biology, 2012 Peptidase S (PEPS) is a metallopeptidase that cleaves N -terminal residues from proteins and peptides. PEPS is used as a cell maintenance enzyme with critical roles in peptide turnover. The promoter region located upstream of the initiation site plays an important role in regulating gene ...
Zhihua, Ju +7 more
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The potential for reassortment between Oropouche and Schmallenberg Orthobunyaviruses [PDF]
, 2017 A number of viruses within the Peribunyaviridae family are naturally occurring reassortants, a common phenomenon for segmented viruses. Using a minigenome-reporter and virus-like particle (VLP) production assay, we have accessed the potential of ...
Elliott, Richard M. +3 more
core +1 more source
Mechanisms underlying the tissue-specific and regulated activity of the Gnrhr promoter in mammals.
Frontiers in Endocrinology, 2012 The GnRH receptor (GnRHR) plays a central role in the development and maintenance of reproductive function in mammals. Following stimulation by GnRH originating from the hypothalamus, GnRHR triggers multiple signalling events that ultimately stimulate ...
Anne-Laure eSchang +7 more
doaj +1 more source
Positive selection in coding regions and motif duplication in regulatory regions of bottlenose dolphin MHC class II genes. [PDF]
PLoS ONE, 2018 The vertebrate immune response is mediated through highly adaptive, quickly evolving cell surface receptors, the major histocompatibility complex (MHC).
Heidi J T Pagán +2 more
doaj +1 more source
Relationship between promoter sequence and its strength in gene expression
, 2014 In this study, through various tests one theoretical model is presented to describe the relationship between promoter strength and its nucleotide sequence.
Li, Jingwei, Zhang, Yunxin
core +1 more source
Slx5/Slx8-dependent ubiquitin hotspots on chromatin contribute to stress tolerance [PDF]
, 2019 Chromatin is a highly regulated environment, and protein association with chromatin is often controlled by post-translational modifications and the corresponding enzymatic machinery.
Habermann, B. +6 more
core +3 more sources
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel +3 more
wiley +1 more source
Genetic Dissection of the Light-InduciblecarQRSPromoter Region ofMyxococcus xanthus [PDF]
Journal of Bacteriology, 2004 ABSTRACTInMyxococcus xanthusphotoprotective carotenoids are produced in response to illumination due to regulated expression of carotenoid biosynthesis genes at two loci. Induction of the carotenogenesis regulon is dependent on expression of thecarQRSoperon.
David E, Whitworth +4 more
openaire +2 more sources
Molecular characterization of the giant freshwater prawn (Macrobrachium rosenbergii) beta-actin gene promoter [PDF]
PeerJ, 2018 Constitutive promoters are important tools for gene function studies and transgenesis. The Beta-actin (actb1) gene promoter has been isolated from many species but remains to be cloned from the giant freshwater prawn (Macrobrachium rosenbergii).
Junjun Yan +4 more
doaj +2 more sources
The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing. [PDF]
, 2019 Transcriptional regulation in eukaryotes occurs at promoter-proximal regions wherein transcriptionally engaged RNA polymerase II (Pol II) pauses before proceeding toward productive elongation.
Ablondi, Eileen +20 more
core +1 more source