Results 41 to 50 of about 390,492 (308)

Positive selection in coding regions and motif duplication in regulatory regions of bottlenose dolphin MHC class II genes. [PDF]

PLoS ONE, 2018
The vertebrate immune response is mediated through highly adaptive, quickly evolving cell surface receptors, the major histocompatibility complex (MHC).
Heidi J T Pagán, Tatiana Ferrer, Greg O'Corry-Crowe   +2 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Haptoglobin and sickle cell polymorphisms and risk of active trachoma in Gambian children. [PDF]

, 2010
BACKGROUND: Susceptibility and resistance to trachoma, the leading infectious cause of blindness, have been associated with a range of host genetic factors.
Doherty, CP, Andrew M Prentice, Martin J. Holland, Hennig, Branwen J, Bailey Robin, Kirk A Rockett, Fulford Anthony J., Kwiatkowski, DP, Fulford, AJ, Sharon E. Cox, Kwiatkowski, Dominic, Dominic P Kwiatkowski, Kwiatkowski Dominic P., Kirk A. Rockett, Sharon E Cox, Rockett, KA, Hennig Branwen J., Fulford, Anthony J, Dominic P. Kwiatkowski, Holland, MJ, Holland, Martin J, Cox, Sharon E, Mathilde Savy, Holland Martin J., Robin Bailey, Prentice, AM, Sirugo, G, Martin J Holland, Prentice, Andrew M, Anthony J Fulford, Sirugo, Giorgio, Bailey, Robin, Savy Mathilde, Conor P Doherty, Rockett, Kirk A, Bailey, R, Branwen J Hennig, Cox Sharon E., Doherty, Conor P, Cox, SE, Savy, M, Rockett Kirk A., Andrew M. Prentice, Prentice Andrew M., Anthony J. Fulford, Hennig, BJ, Conor P. Doherty, Sirugo Giorgio, Savy, Mathilde, Doherty Conor P., Branwen J. Hennig, Kwiatkowski, Dominic P, Giorgio Sirugo   +52 more
core   +1 more source

TERT Promoter Mutation Analysis of Whole-Organ Mapping Bladder Cancers

, 2021
Background: Multifocal occurrence is a main characteristic of urothelial bladder cancer (UBC). Whether urothelial transformation is caused by monoclonal events within the urothelium, or by polyclonal unrelated events resulting in several tumor clones is ...
Danijel Sikic, Wullich, Bernd, Weyerer, Veronika, Taubert, Helge, Sikic, Danijel, Tögel, Lars, Geppert, Carol I., Robert Stoehr, Adrian Wullweber, Carol I. Geppert, Hartmann, Arndt, Strissel, Pamela L., Lange, Fabienne, Giedl, Johannes, Veronika Weyerer, Stoehr, Robert, Wullweber, Adrian, Wach, Sven, Pamela L. Strissel, Fabienne Lange, Sven Wach, Helge Taubert, Lars Tögel, Arndt Hartmann, Johannes Giedl, Bernd Wullich, Markus Eckstein, Eckstein, Markus   +27 more
core   +1 more source

Molecular characterization of the giant freshwater prawn (Macrobrachium rosenbergii) beta-actin gene promoter [PDF]

PeerJ, 2018
Constitutive promoters are important tools for gene function studies and transgenesis. The Beta-actin (actb1) gene promoter has been isolated from many species but remains to be cloned from the giant freshwater prawn (Macrobrachium rosenbergii).
Junjun Yan, Qiang Gao, Zongbin Cui, Guoliang Yang, Yong Long   +4 more
doaj   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Cooperativity of Glucocorticoid Response Elements Located Far Upstream of the Tyrosine Aminotransferase Gene [PDF]

, 1987
Two glucocorticoid response elements (GREs) located 2.5 kb upstream of the transcription initiation site of the tyrosine aminotransferase gene were identified by gene transfer experiments and shown to bind to purified glucocorticoid receptor.
Strähle, Uwe, Boshart, Michael, Schmid, Wolfgang, Miksicek, Richard, Jansen, Hans-Michael, Gloss, Bernd, Schlitz, Günther, Stewart, Francis   +7 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Functional mapping of pea legumin upstream regulatory elements using TI plasmid vectors [PDF]

, 1991
The leg A gene from Pisum sativum L. has been extensively characterised and a distinct pattern of developmental and organ-specific gene expression demonstrated.
Garrett, Christine, Garrett, C
core