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Diversity and Emerging Roles of Enhancer RNA in Regulation of Gene Expression and Cell Fate
Frontiers in Cell and Developmental Biology, 2020 Enhancers are cis-regulatory elements in the genome that cooperate with promoters to control target gene transcription. Unlike promoters, enhancers are not necessarily adjacent to target genes and can exert their functions regardless of enhancer ...
Preston R. Arnold +3 more
doaj +2 more sources
Transcriptional control by enhancers and enhancer RNAs [PDF]
Transcription, 2019 The regulation of gene expression is a fundamental cellular process and its misregulation is a key component of disease. Enhancers are one of the most salient regulatory elements in the genome and help orchestrate proper spatiotemporal gene expression during development, in homeostasis, and in response to signaling.
Hector L Franco, Michael Lewis
exaly +3 more sources
Decreased Enhancer-Promoter Proximity Accompanying Enhancer Activation
Molecular Cell, 2019 Summary Enhancers can regulate the promoters of their target genes over very large genomic distances. It is widely assumed that mechanisms of enhancer action involve the reorganization of three-dimensional chromatin architecture, but this is poorly ...
Wendy Bickmore +2 more
exaly +2 more sources
Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis
Cell, 2017 Summary Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human malignancies, owing in part to its propensity for metastasis. Here, we used an organoid culture system to investigate how transcription and the enhancer landscape become ...
Hervé Tiriac +2 more
exaly +2 more sources
Cell, 2018 Summary Increased androgen receptor (AR) activity drives therapeutic resistance in advanced prostate cancer. The most common resistance mechanism is amplification of this locus presumably targeting the AR gene.
Zoltan Szallasi +2 more
exaly +2 more sources
Journal of Bioethical Inquiry, 2022 AbstractTransgender healthcare faces a dilemma. On the one hand, access to certain medical interventions, including hormone treatments or surgeries, where desired, may be beneficial or even vital for some gender dysphoric trans people. But on the other hand, access to medical interventions typically requires a diagnosis, which, in turn, seems to imply ...
Hazem Zohny +2 more
openaire +3 more sources
Molecular Therapy: Nucleic Acids, 2021 Glioma is the most common malignancy in the central nervous system with no immediate prospect of a cure. Comprehensive understanding on the pathogenesis of the disorder contributes to a better outcome.
Meixiong Cheng +5 more
doaj +1 more source
Enhancing Photorealism Enhancement
IEEE Transactions on Pattern Analysis and Machine Intelligence, 2023 Code and data available at https://github.com/intel-isl/PhotorealismEnhancement Video available at https://youtu.be ...
Stephan R. Richter +2 more
openaire +3 more sources
Genome-wide enhancer maps link risk variants to disease genes
Nature, 2021 Genome-wide association studies (GWAS) have identified thousands of noncoding loci that are associated with human diseases and complex traits, each of which could reveal insights into the mechanisms of disease1. Many of the underlying causal variants may
J. Nasser +31 more
semanticscholar +1 more source
Nonlinear control of transcription through enhancer–promoter interactions
Nature, 2022 Chromosome structure in mammals is thought to regulate transcription by modulating three-dimensional interactions between enhancers and promoters, notably through CTCF-mediated loops and topologically associating domains (TADs)1–4.
J. Zuin +15 more
semanticscholar +1 more source