Transcriptional control by enhancers and enhancer RNAs [PDF]
Transcription, 2019 The regulation of gene expression is a fundamental cellular process and its misregulation is a key component of disease. Enhancers are one of the most salient regulatory elements in the genome and help orchestrate proper spatiotemporal gene expression during development, in homeostasis, and in response to signaling.
Michael W Lewis +2 more
exaly +3 more sources
Lingering Questions about Enhancer RNA and Enhancer Transcription-Coupled Genomic Instability
Trends in Genetics, 2017Gerson Rothschild, Uttiya Basu
exaly
Enhancer and super‐enhancer: Positive regulators in gene transcription
Animal Models and Experimental Medicine, 2018Yanling Peng, Yubo Zhang
exaly
LSD1 Controls Timely MyoD Expression via MyoD Core Enhancer Transcription
Cell Reports, 2017Shinichiro Hayashi +2 more
exaly
A suite of enhancer AAVs and transgenic mouse lines for genetic access to cortical cell types
Cellexaly
Diversity and Emerging Roles of Enhancer RNA in Regulation of Gene Expression and Cell Fate
Frontiers in Cell and Developmental Biology, 2020 Enhancers are cis-regulatory elements in the genome that cooperate with promoters to control target gene transcription. Unlike promoters, enhancers are not necessarily adjacent to target genes and can exert their functions regardless of enhancer ...
Preston R. Arnold +3 more
doaj +2 more sources
Comprehensive In Vivo Interrogation Reveals Phenotypic Impact of Human Enhancer Variants
Cell, 2020 Summary Establishing causal links between non-coding variants and human phenotypes is an increasing challenge. Here we introduce a high-throughput mouse reporter assay for assessing the pathogenic potential of human enhancer variants in vivo and examine ...
Evgeny Z Kvon +2 more
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Decreased Enhancer-Promoter Proximity Accompanying Enhancer Activation
Molecular Cell, 2019 Summary Enhancers can regulate the promoters of their target genes over very large genomic distances. It is widely assumed that mechanisms of enhancer action involve the reorganization of three-dimensional chromatin architecture, but this is poorly ...
Nezha S Benabdallah +2 more
exaly +2 more sources
Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis
Cell, 2017 Summary Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal human malignancies, owing in part to its propensity for metastasis. Here, we used an organoid culture system to investigate how transcription and the enhancer landscape become ...
Jae-Seok Roe +2 more
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A High-Resolution Map of Human Enhancer RNA Loci Characterizes Super-enhancer Activities in Cancer
Cancer Cell, 2020 Summary Although enhancers play critical roles in cancer, quantifying enhancer activities in clinical samples remains challenging, especially for super-enhancers.
Han Chen, Han Liang
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