Results 1 to 10 of about 370,708 (316)

Transcription Factor ELF1 Activates MEIS1 Transcription and Then Regulates the GFI1/FBW7 Axis to Promote the Development of Glioma

Molecular Therapy: Nucleic Acids, 2021
Glioma is the most common malignancy in the central nervous system with no immediate prospect of a cure. Comprehensive understanding on the pathogenesis of the disorder contributes to a better outcome.
Meixiong Cheng, Yi Zeng, Tian Zhang, Min Xu, Zhili Li, Yaqiu Wu   +5 more
doaj   +1 more source

Diversity and Emerging Roles of Enhancer RNA in Regulation of Gene Expression and Cell Fate

Frontiers in Cell and Developmental Biology, 2020
Enhancers are cis-regulatory elements in the genome that cooperate with promoters to control target gene transcription. Unlike promoters, enhancers are not necessarily adjacent to target genes and can exert their functions regardless of enhancer ...
Preston R. Arnold, Preston R. Arnold, Andrew D. Wells, Xian C. Li   +3 more
doaj   +1 more source

Interleukin-7 receptor signaling is crucial for enhancer-dependent TCRδ germline transcription mediated through STAT5 recruitment

Frontiers in Immunology, 2022
γδ T cells play important roles in immune responses by rapidly producing large quantities of cytokines. Recently, γδ T cells have been found to be involved in tissue homeostatic regulation, playing roles in thermogenesis, bone regeneration and synaptic ...
Alonso Rodríguez-Caparrós, Shizue Tani-ichi, Áurea Casal, Jennifer López-Ros, Carlos Suñé, Koichi Ikuta, Cristina Hernández-Munain   +6 more
doaj   +1 more source

Global Analysis of Transcription Start Sites in the New Ovine Reference Genome (Oar rambouillet v1.0)

Frontiers in Genetics, 2020
The overall aim of the Ovine FAANG project is to provide a comprehensive annotation of the new highly contiguous sheep reference genome sequence (Oar rambouillet v1.0).
Mazdak Salavati, Mazdak Salavati, Alex Caulton, Alex Caulton, Richard Clark, Iveta Gazova, Iveta Gazova, Timothy P. L. Smith, Kim C. Worley, Noelle E. Cockett, Alan L. Archibald, Shannon M. Clarke, Brenda M. Murdoch, Emily L. Clark, Emily L. Clark   +14 more
doaj   +1 more source

Pterostilbene Changes Epigenetic Marks at Enhancer Regions of Oncogenes in Breast Cancer Cells

Antioxidants, 2021
Epigenetic aberrations are linked to sporadic breast cancer. Interestingly, certain dietary polyphenols with anti-cancer effects, such as pterostilbene (PTS), have been shown to regulate gene expression by altering epigenetic patterns.
Sadaf Harandi-Zadeh, Cayla Boycott, Megan Beetch, Tony Yang, Benjamin J. E. Martin, Kevin Ren, Anna Kwasniak, John H. Dupuis, Katarzyna Lubecka, Rickey Y. Yada, LeAnn J. Howe, Barbara Stefanska   +11 more
doaj   +1 more source

iEnhancer-EBLSTM: Identifying Enhancers and Strengths by Ensembles of Bidirectional Long Short-Term Memory

Frontiers in Genetics, 2021
Enhancers are regulatory DNA sequences that could be bound by specific proteins named transcription factors (TFs). The interactions between enhancers and TFs regulate specific genes by increasing the target gene expression.
Kun Niu, Ximei Luo, Shumei Zhang, Zhixia Teng, Tianjiao Zhang, Yuming Zhao   +5 more
doaj   +1 more source

Comprehensive landscape of epigenetic-dysregulated lncRNAs reveals a profound role of enhancers in carcinogenesis in BC subtypes

Molecular Therapy: Nucleic Acids, 2021
Aberrant expression of long non-coding RNAs (lncRNA) is associated with altered DNA methylation and histone modifications during carcinogenesis. However, identifying epigenetically dysregulated lncRNAs and characterizing their functional mechanisms in ...
Hongying Zhao, Xiaoqin Liu, Lei Yu, Shihua Lin, Caiyu Zhang, Haotian Xu, Zhijun Leng, Waidong Huang, Junjie Lei, Tengyue Li, Jing Li, Fan Yang, Li Wang   +12 more
doaj   +1 more source

Establishment of regions of genomic activity during the Drosophila maternal to zygotic transition

eLife, 2014
We describe the genome-wide distributions and temporal dynamics of nucleosomes and post-translational histone modifications throughout the maternal-to-zygotic transition in embryos of Drosophila melanogaster.
Xiao-Yong Li, Melissa M Harrison, Jacqueline E Villalta, Tommy Kaplan, Michael B Eisen   +4 more
doaj   +1 more source

Switch Tandem Repeats Influence the Choice of the Alternative End-Joining Pathway in Immunoglobulin Class Switch Recombination

Frontiers in Immunology, 2022
Immunoglobulin class switch recombination (CSR) plays an important role in humoral imm\une responses by changing the effector functions of antibodies. CSR occurs between highly repetitive switch (S) sequences located upstream of immunoglobulin constant ...
Chloé Oudinet, Xuefei Zhang, Nadine Puget, Nia Kyritsis, Claire Leduc, Fatima-Zohra Braikia, Audrey Dauba, Frederick W. Alt, Ahmed Amine Khamlichi   +8 more
doaj   +1 more source

Discovery and validation of sub-threshold genome-wide association study loci using epigenomic signatures

eLife, 2016
Genetic variants identified by genome-wide association studies explain only a modest proportion of heritability, suggesting that meaningful associations lie 'hidden' below current thresholds.
Xinchen Wang, Nathan R Tucker, Gizem Rizki, Robert Mills, Peter HL Krijger, Elzo de Wit, Vidya Subramanian, Eric Bartell, Xinh-Xinh Nguyen, Jiangchuan Ye, Jordan Leyton-Mange, Elena V Dolmatova, Pim van der Harst, Wouter de Laat, Patrick T Ellinor, Christopher Newton-Cheh, David J Milan, Manolis Kellis, Laurie A Boyer   +18 more
doaj   +1 more source