Results 1 to 10 of about 11,616,396 (211)
Post-transcriptional gene regulation by mRNA modifications
Nature Reviews Molecular Cell Biology, 2016 The recent discovery of reversible mRNA methylation has opened a new realm of post-transcriptional gene regulation in eukaryotes. The identification and functional characterization of proteins that specifically recognize RNA N6-methyladenosine (m6A ...
Boxuan Simen Zhao +2 more
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Gene Regulation and Speciation [PDF]
Trends in Genetics, 2016 Understanding the genetic architecture of speciation is a major goal in evolutionary biology. Hybrid dysfunction is thought to arise most commonly through negative interactions between alleles at two or more loci.
Katya L. Mack, M. Nachman
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Understanding Tissue-Specific Gene Regulation
Cell Reports, 2017 Although all human tissues carry out common processes, tissues are distinguished by gene expres-sion patterns, implying that distinct regulatory programs control tissue-specificity.
Abhijeet R Sonawane +2 more
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Gene Regulation and Transcriptomics [PDF]
Current Issues in Molecular Biology, 2021 Borrelia (Borreliella) burgdorferi, along with closely related species, is the etiologic agent of Lyme disease. The spirochete subsists in an enzootic cycle that encompasses acquisition from a vertebrate host to a tick vector and transmission from a tick vector to a vertebrate host.
Samuels, D. Scott +8 more
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The molecular principles of gene regulation by Polycomb repressive complexes
Nature reviews. Molecular cell biology, 2021 Precise control of gene expression is fundamental to cell function and development. Although ultimately gene expression relies on DNA-binding transcription factors to guide the activity of the transcription machinery to genes, it has also become clear ...
Neil P. Blackledge, R. Klose
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Applications of deep learning in understanding gene regulation
Cell Reports Methods, 2023 Summary Gene regulation is a central topic in cell biology. Advances in omics technologies and the accumulation of omics data have provided better opportunities for gene regulation studies than ever before. For this reason deep learning, as a data-driven
Zhongxiao Li +5 more
semanticscholar +1 more source
Regulation of the Globin Genes [PDF]
Pediatric Research, 2002 The a- and b-globin gene clusters are subject to several levels of regulation. They are expressed exclusively in the erythroid cells, only during defined periods of development and in a perfectly tuned way, assuring, at any stage of ontogeny, a correct balance in the availability of a- and b-globin chains for hemoglobin assembling. Such a tight control
Cao A, MOI, PAOLO
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Cell & Bioscience, 2022 Background Bile acid (BA) homeostasis is mainly regulated by bile salt excretory pump (BSEP), a hepatocyte transporter that transfers BAs to the bile.
Javier Martínez-García +6 more
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CTCF and cohesin promote focal detachment of DNA from the nuclear lamina
Genome Biology, 2022 Background Lamina-associated domains (LADs) are large genomic regions that are positioned at the nuclear lamina. It has remained largely unclear what drives the positioning and demarcation of LADs.
Tom van Schaik +5 more
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Crosstalk between epitranscriptomic and epigenetic mechanisms in gene regulation
Trends in Genetics, 2021 Epigenetic modifications occur on genomic DNA and histones to influence gene expression. More recently, the discovery that mRNA undergoes similar chemical modifications that powerfully impact transcript turnover and translation adds another layer of ...
Ryan L. Kan, Jianjun Chen, T. Sallam
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